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Biology and Biochemistry
Spain
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
90
Citations
28225
World Ranking
2444
National Ranking
28

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Spain Leader Award

Overview

Manuel Palacín is affiliated with the Institute for Research in Biomedicine in Spain. Their research spans several interconnected fields within biochemistry, genetics, molecular biology, and medicine, with a focus on understanding molecular and cellular mechanisms underlying physiological and pathological processes.

The main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these fields, the subfields of study that feature prominently in their work are:

  • Molecular Biology
  • Biochemistry
  • Physiology
  • Epidemiology
  • Clinical Biochemistry

The primary research topics covered by Manuel Palacín emphasize biochemical and molecular pathways, with key areas being:

  • Amino Acid Enzymes and Metabolism
  • Epigenetics and DNA Methylation
  • Mitochondrial Function and Pathology
  • Adipose Tissue and Metabolism
  • ATP Synthase and ATPases Research
  • Metabolism and Genetic Disorders
  • Autophagy in Disease and Therapy

Recent publications highlight a focus on mitochondrial dynamics, interorganellar communication, and cellular metabolism, including:

  • "Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria," 2023, Science
  • "Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation," 2023, Nature Communications
  • "Coordination of mitochondrial and lysosomal homeostasis mitigates inflammation and muscle atrophy during aging," 2022, Aging Cell
  • "Facilitated Diffusion of Proline across Membranes of Liposomes and Living Cells by a Calix[4]pyrrole Cavitand," 2020, Chem
  • "Membrane Protein Stabilization Strategies for Structural and Functional Studies," 2021, Membranes

Manuel Palacín frequently collaborates with several other researchers, notably:

  • António Zorzano
  • David Sebastián
  • Ekaitz Errasti-Murugarren
  • Paola Bartoccioni
  • Susanna Bodoy

In terms of publication venues, they have multiple contributions in the following journals:

  • Nature Communications
  • Autophagy
  • Membranes
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Current Opinion in Structural Biology

Best Publications

  • Mitochondrial Dynamics in Mammalian Health and Disease

    Marc Liesa;Manuel Palacín;Antonio Zorzano

  • Mitofusin-2 Determines Mitochondrial Network Architecture and Mitochondrial Metabolism A NOVEL REGULATORY MECHANISM ALTERED IN OBESITY

    Daniel Bach;Sara Pich;Francesc X. Soriano;Nathalie Vega

  • Molecular Biology of Mammalian Plasma Membrane Amino Acid Transporters

    Manuel Palacín;Raúl Estévez;Joan Bertran;Antonio Zorzano

  • CATs and HATs: the SLC7 family of amino acid transporters

    François Verrey;Ellen I. Closs;Carsten A. Wagner;Manuel Palacin

  • The SLC3 and SLC7 families of amino acid transporters

    Dimitrios Fotiadis;Yoshikatsu Kanai;Manuel Palacín

  • Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

    David Sebastián;María Isabel Hernández-Alvarez;Jessica Segalés;Eleonora Sorianello

  • The Charcot–Marie–Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system

    Sara Pich;Daniel Bach;Paz Briones;Marc Liesa

  • Identification and Characterization of a Membrane Protein (y+L Amino Acid Transporter-1) That Associates with 4F2hc to Encode the Amino Acid Transport Activity y+L A CANDIDATE GENE FOR LYSINURIC PROTEIN INTOLERANCE

    David Torrents;Raúl Estévez;Marta Pineda;Esperanza Fernández

  • Expression of Mfn2, the Charcot-Marie-Tooth Neuropathy Type 2A Gene, in Human Skeletal Muscle Effects of Type 2 Diabetes, Obesity, Weight Loss, and the Regulatory Role of Tumor Necrosis Factor α and Interleukin-6

    Daniel Bach;Deborah Naon;Sara Pich;Francesc X. Soriano

  • Cystinuria caused by mutations in rBAT , a gene involved in the transport of cystine

    María Julia Calonge;Paolo Gasparini;Josep Chillarón;Miguel Chillón

  • Mfn2 modulates the UPR and mitochondrial function via repression of PERK.

    Juan Pablo Muñoz;Saška Ivanova;Saška Ivanova;Jana Sánchez-Wandelmer;Jana Sánchez-Wandelmer;Paula Martínez-Cristóbal;Paula Martínez-Cristóbal

  • Evidence for a Mitochondrial Regulatory Pathway Defined by Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α, Estrogen-Related Receptor-α, and Mitofusin 2

    Franscesc X. Soriano;Marc Liesa;Daniel Bach;David C. Chan

  • Identification of a Membrane Protein, LAT-2, That Co-expresses with 4F2 Heavy Chain, an L-type Amino Acid Transport Activity with Broad Specificity for Small and Large Zwitterionic Amino Acids

    Marta Pineda;Esperanza Fernández;David Torrents;Raúl Estévez

  • Non-type I cystinuria caused by mutations in SLC7A9, encoding a subunit (bo,+AT) of rBAT.

    Lídia Feliubadaló;Mariona Font;Jesús Purroy;Ferran Rousaud

  • Identification of SLC7A7, encoding y+LAT-1, as the lysinuric protein intolerance gene.

    D Torrents;J Mykkänen;M Pineda;L Feliubadaló

  • Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway

    David Sebastián;David Sebastián;Eleonora Sorianello;Eleonora Sorianello;Jessica Segalés;Jessica Segalés;Andrea Irazoki

  • Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease

    María Isabel Hernández-Alvarez;David Sebastián;David Sebastián;Sara Vives;Saška Ivanova;Saška Ivanova

  • Identification of LAT4, a novel amino acid transporter with system L activity.

    Susanna Bodoy;Lorena Martín;Antonio Zorzano;Manuel Palacín

  • Mechanisms regulating GLUT4 glucose transporter expression and glucose transport in skeletal muscle.

    A. Zorzano;M. Palacin;A. Guma

  • Developmental regulation of GLUT-1 (erythroid/Hep G2) and GLUT-4 (muscle/fat) glucose transporter expression in rat heart, skeletal muscle, and brown adipose tissue.

    T Santalucía;M Camps;A Castelló;P Muñoz

Frequent Co-Authors

Antonio Zorzano
Antonio Zorzano University of Barcelona
Virginia Nunes
Virginia Nunes University of Barcelona
Paolo Gasparini
Paolo Gasparini University of Trieste
David Torrents
David Torrents Barcelona Supercomputing Center
Leopoldo Zelante
Leopoldo Zelante Casa Sollievo della Sofferenza
Dimitrios Fotiadis
Dimitrios Fotiadis University of Bern
Heini Murer
Heini Murer University of Zurich
Florian Lang
Florian Lang University of Tübingen
Stefan Bröer
Stefan Bröer Australian National University

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