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Biology and Biochemistry

D-Index
83
Citations
48111
World Ranking
3417
National Ranking
1722

Overview

Orian S. Shirihai is affiliated with the University of California, Los Angeles in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions to medicine. Within these broad fields, they have specialized in molecular biology, physiology, pulmonary and respiratory medicine, cancer research, and epidemiology.

The scientist's work extensively covers several main topics, including mitochondrial function and pathology, adipose tissue and metabolism, metabolomics and mass spectrometry studies, metabolic and genetic disorders, ATP synthase and ATPases research, cancer, hypoxia, and metabolism, as well as pancreatic function and diabetes.

They have authored multiple recent papers in high-impact journals, among them:

  • Mitochondrial signal transduction, 2022, published in Cell Metabolism
  • A novel approach to measure mitochondrial respiration in frozen biological samples, 2020, The EMBO Journal
  • Cristae undergo continuous cycles of membrane remodelling in a MICOS-dependent manner, 2020, EMBO Reports
  • Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA, 2023, The EMBO Journal
  • Spatial mapping of mitochondrial networks and bioenergetics in lung cancer, 2023, Nature

Orian S. Shirihai collaborates frequently with several co-authors, including Linsey Stiles (39 joint publications), Marc Liesa (31), Rebeca Acín-Pérez (26), Anton Petcherski (25), and Michaela Veliova (14).

Their research has been published in a range of scientific venues, with the most frequent publication outlets being bioRxiv (Cold Spring Harbor Laboratory) with 19 publications, Nature (5), Biochimica et Biophysica Acta (BBA) - Bioenergetics (5), EMBO Reports (4), and Nature Communications (4).

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

    Gilad Twig;Alvaro Elorza;Anthony J A Molina;Anthony J A Molina;Hibo Mohamed

  • Pancreatic cancers require autophagy for tumor growth

    Shenghong Yang;Xiaoxu Wang;Gianmarco Contino;Marc Liesa

  • Telomere dysfunction induces metabolic and mitochondrial compromise

    Ergiin Sahin;Simona Colla;Marc Liesa;Javid Moslehi

  • Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure.

    Marc Liesa;Orian S. Shirihai;Orian S. Shirihai

  • The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

    Lei Zhong;Agustina D'Urso;Debra Toiber;Carlos Sebastian

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • The Interplay Between Mitochondrial Dynamics and Mitophagy

    Gilad Twig;Orian S. Shirihai

  • Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view

    Gilad Twig;Brigham Hyde;Brigham Hyde;Orian S. Shirihai;Orian S. Shirihai

  • Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion

    Ilan Y. Benador;Ilan Y. Benador;Michaela Veliova;Kiana Mahdaviani;Anton Petcherski

  • Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells

    Sameer Kalghatgi;Catherine S. Spina;Catherine S. Spina;Catherine S. Spina;James C. Costello;Marc Liesa

  • Altered Mitochondrial Dynamics Contributes to Endothelial Dysfunction in Diabetes Mellitus

    Sherene M. Shenouda;Michael E. Widlansky;Kai Chen;Guoquan Xu

  • Mitochondrial Networking Protects β-Cells From Nutrient-Induced Apoptosis

    Anthony J.A. Molina;Jakob D. Wikstrom;Jakob D. Wikstrom;Linsey Stiles;Linsey Stiles;Guy Las

  • The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

    Sushma Gurumurthy;Stephanie Z. Xie;Brinda Alagesan;Judith Kim

  • Mitochondrial 'kiss-and-run': interplay between mitochondrial motility and fusion-fission dynamics.

    Xingguo Liu;David Weaver;Orian Shirihai;György Hajnóczky

  • Dual role of proapoptotic BAD in insulin secretion and beta cell survival

    Nika N Danial;Loren D Walensky;Chen-Yu Zhang;Cheol Soo Choi

  • Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer

    Jian Hu;Soyoon Sarah Hwang;Soyoon Sarah Hwang;Marc Liesa;Boyi Gan

  • Mitochondrial morphology transitions and functions: implications for retrograde signaling?

    Martin Picard;Orian S. Shirihai;Benoit J. Gentil;Yan Burelle

  • How Mitochondrial Dynamism Orchestrates Mitophagy

    Orian S. Shirihai;Orian S. Shirihai;Moshi Song;Gerald W. Dorn

Frequent Co-Authors

Barbara E. Corkey
Barbara E. Corkey Boston University
Mark W. Grinstaff
Mark W. Grinstaff Boston University
Wilson S. Colucci
Wilson S. Colucci Boston University
Darrell N. Kotton
Darrell N. Kotton Boston University
Evelina Gatti
Evelina Gatti Aix-Marseille University
Alicia J. Kowaltowski
Alicia J. Kowaltowski Universidade de São Paulo
Sergio Lavandero
Sergio Lavandero University of Chile
Shazib Pervaiz
Shazib Pervaiz National University of Singapore
Peter Smith
Peter Smith University of Aberdeen
Antonio Zorzano
Antonio Zorzano University of Barcelona

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