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Alicia J. Kowaltowski

Alicia J. Kowaltowski

D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
18696
World Ranking
5621
National Ranking
12

Overview

Alicia J. Kowaltowski is affiliated with the Universidade de São Paulo in Brazil. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine, with significant contributions to Molecular Biology and Physiology. The scientist's work also engages with subfields such as Epidemiology, Aging, and Cancer Research.

The main topics explored in Kowaltowski's research include mitochondrial function and pathology, adipose tissue and metabolism, and genetics, aging, and longevity in model organisms. Additional areas of focus encompass ATP synthase and ATPases research, metabolism and genetic disorders, autophagy in disease and therapy, and pancreatic function and diabetes.

Notable recent publications feature a range of studies addressing mitochondrial and metabolic processes. These include:

  • Goldilocks calcium concentrations and the regulation of oxidative phosphorylation: Too much, too little, or just right (2023), published in Journal of Biological Chemistry
  • Satellite cell self-renewal in endurance exercise is mediated by inhibition of mitochondrial oxygen consumption (2020), in Journal of Cachexia Sarcopenia and Muscle
  • Increased glycolysis is an early consequence of palmitate lipotoxicity mediated by redox signaling (2021), appearing in Redox Biology
  • A new target for an old DUB: UCH-L1 regulates mitofusin-2 levels, altering mitochondrial morphology, function and calcium uptake (2020), also published in Redox Biology
  • Autophagy in Hepatic Steatosis: A Structured Review (2021), published in Frontiers in Cell and Developmental Biology

Kowaltowski has collaborated frequently with several coauthors, including Camille C. Caldeira da Silva, Julian D. C. Serna, Eloisa Aparecida Vilas-Boas, João Victor Cabral-Costa, and Vítor de Miranda Ramos.

The scientist's work has been disseminated in multiple publication venues, with frequent contributions to bioRxiv (Cold Spring Harbor Laboratory), Free Radical Biology and Medicine, The FASEB Journal, Journal of Bioenergetics and Biomembranes, and Redox Biology.

Best Publications

  • Mitochondria and reactive oxygen species.

    Alicia Juliana Kowaltowski;Nadja Cristhina de Souza-Pinto;Roger Frigério Castilho;Anibal Eugenio Vercesi

  • Mitochondrial damage induced by conditions of oxidative stress

    Alicia J. Kowaltowski;Anibal E. Vercesi

  • Mitochondrial permeability transition and oxidative stress.

    Alicia J. Kowaltowski;Roger F. Castilho;Anibal E. Vercesi

  • Bioenergetic consequences of opening the ATP-sensitive K(+) channel of heart mitochondria.

    Alicia J. Kowaltowski;Subramaniam Seetharaman;Petr Paucek;Keith D. Garlid

  • Tissue-, substrate-, and site-specific characteristics of mitochondrial reactive oxygen species generation.

    Erich B. Tahara;Felipe D.T. Navarete;Alicia J. Kowaltowski

  • Mitochondria as a Source of Reactive Oxygen and Nitrogen Species: From Molecular Mechanisms to Human Health

    Tiago R Figueira;Mario H Barros;Anamaria A Camargo;Roger F Castilho

  • Soluble Uric Acid Activates the NLRP3 Inflammasome

    Tarcio Teodoro Braga;Maria Fernanda Forni;Matheus Correa-Costa;Rodrigo Nalio Ramos

  • Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity.

    Camille Cristine Caldeira da Silva;Fernanda Menezes Cerqueira;Lívea Fujita Barbosa;Marisa Helena Gennari de Medeiros

  • The role of reactive oxygen species in mitochondrial permeability transition

    Anibal E. Vercesi;Alicia J. Kowaltowski;Mercedes T. Grijalba;André R. Meinicke

  • Identification and Properties of a Novel Intracellular (Mitochondrial) ATP-sensitive Potassium Channel in Brain

    Robert Bajgar;Subramaniam Seetharaman;Alicia J. Kowaltowski;Keith D. Garlid

  • Higher respiratory activity decreases mitochondrial reactive oxygen release and increases life span in Saccharomyces cerevisiae.

    Mario H. Barros;Brian Bandy;Erich B. Tahara;Alicia J. Kowaltowski

  • Opening of the mitochondrial permeability transition pore by uncoupling or inorganic phosphate in the presence of Ca2+ is dependent on mitochondrial-generated reactive oxygen species

    Alicia J. Kowaltowski;Roger F. Castilho;Anibal E. Vercesi

  • Mechanisms by which opening the mitochondrial ATP- sensitive K+ channel protects the ischemic heart

    Pierre Dos Santos;Alicia J. Kowaltowski;Muriel N. Laclau;Subramanian Seetharaman

  • Permeabilization of the inner mitochondrial membrane by Ca2+ ions is stimulated by t-butyl hydroperoxide and mediated by reactive oxygen species generated by mitochondria

    Roger F. Castilho;Alicia J. Kowaltowski;AndréR. Meinicke;Etelvino J.H. Bechara

  • Binding, Aggregation and Photochemical Properties of Methylene Blue in Mitochondrial Suspensions

    Dino Gabrielli;Eduardo Belisle;Divinomar Severino;Alicia J. Kowaltowski

  • Effect of inorganic phosphate concentration on the nature of inner mitochondrial membrane alterations mediated by Ca2+ ions. A proposed model for phosphate-stimulated lipid peroxidation.

    Alicia J. Kowaltowski;Roger F. Castilho;Mercedes T. Grijalba;Etelvino J.H. Bechara

  • Activation of the potato plant uncoupling mitochondrial protein inhibits reactive oxygen species generation by the respiratory chain.

    Alicia J Kowaltowski;Alexandre D.T Costa;Anibal E Vercesi

  • The Thiol-specific Antioxidant Enzyme Prevents Mitochondrial Permeability Transition EVIDENCE FOR THE PARTICIPATION OF REACTIVE OXYGEN SPECIES IN THIS MECHANISM

    Alicia J. Kowaltowski;Luis E.S. Netto;Anibal E. Vercesi

  • Bcl-2 prevents mitochondrial permeability transition and cytochrome c release via maintenance of reduced pyridine nucleotides.

    A J Kowaltowski;A E Vercesi;G Fiskum

  • Ca(2+)-induced mitochondrial membrane permeabilization: role of coenzyme Q redox state

    A. J. Kowaltowski;R. F. Castilho;A. E. Vercesi

Frequent Co-Authors

Roger F. Castilho
Roger F. Castilho State University of Campinas
Anibal E. Vercesi
Anibal E. Vercesi State University of Campinas
Nadja C. de Souza-Pinto
Nadja C. de Souza-Pinto Universidade de São Paulo
Marisa H. G. Medeiros
Marisa H. G. Medeiros Universidade de São Paulo
Orian S. Shirihai
Orian S. Shirihai University of California, Los Angeles
Mauricio S. Baptista
Mauricio S. Baptista Universidade de São Paulo
Gary Fiskum
Gary Fiskum University of Maryland, Baltimore
Etelvino J. H. Bechara
Etelvino J. H. Bechara Universidade de São Paulo
Keith D. Garlid
Keith D. Garlid Portland State University
Daria Mochly-Rosen
Daria Mochly-Rosen Stanford University

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