World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
13110
World Ranking
8823
National Ranking
35

Overview

What is she best known for?

The fields of study she is best known for:

  • Enzyme
  • Mitochondrion
  • Internal medicine

Her primary areas of study are Oxidative stress, Mitochondrion, Internal medicine, Endocrinology and Diabetes mellitus. Her biological study spans a wide range of topics, including Reactive oxygen species, Glutathione and Insulin. Her Mitochondrion study combines topics in areas such as Alzheimer's disease, Disease, Oxidative phosphorylation and Antioxidant.

Her work on Depolarization is typically connected to Adenine nucleotide as part of general Internal medicine study, connecting several disciplines of science. Her Endocrinology study focuses mostly on Streptozotocin and Carbohydrate metabolism. Her work on Type 2 diabetes as part of general Diabetes mellitus research is often related to Repolarization, thus linking different fields of science.

Her most cited work include:

  • Doxorubicin: The Good, the Bad and the Ugly Effect (585 citations)
  • Carvedilol-mediated antioxidant protection against doxorubicin-induced cardiac mitochondrial toxicity (173 citations)
  • Insulin is a Two-Edged Knife on the Brain (156 citations)

What are the main themes of her work throughout her whole career to date?

Her main research concerns Internal medicine, Endocrinology, Mitochondrion, Oxidative stress and Biochemistry. Her study looks at the relationship between Internal medicine and topics such as Diabetes mellitus, which overlap with Coenzyme Q – cytochrome c reductase. She combines subjects such as Calcium and Vitamin E with her study of Endocrinology.

Her studies in Mitochondrion integrate themes in fields like Oxidative phosphorylation, Pharmacology and Mitochondrial permeability transition pore. Her work deals with themes such as Disease, Antioxidant and Neuroprotection, which intersect with Oxidative stress. Her Biochemistry research includes elements of Biophysics and Respiration.

She most often published in these fields:

  • Internal medicine (49.06%)
  • Endocrinology (48.58%)
  • Mitochondrion (45.75%)

What were the highlights of her more recent work (between 2012-2021)?

  • Internal medicine (49.06%)
  • Endocrinology (48.58%)
  • Mitochondrion (45.75%)

In recent papers she was focusing on the following fields of study:

Maria S. Santos mostly deals with Internal medicine, Endocrinology, Mitochondrion, Insulin and Oxidative stress. Her Internal medicine research includes themes of Liraglutide, Type 2 diabetes and Respiratory chain. Her Endocrinology research is multidisciplinary, incorporating perspectives in Alzheimer's disease, Antioxidant and Cognitive decline.

Her Mitochondrion research incorporates themes from Pharmacology, Phosphorylation and Mitochondrial permeability transition pore. Her Insulin study combines topics from a wide range of disciplines, such as Incretin and Tau protein. When carried out as part of a general Oxidative stress research project, her work on Lipid peroxidation and Protein oxidation is frequently linked to work in Estrogen signaling and Adenine nucleotide, therefore connecting diverse disciplines of study.

Between 2012 and 2021, her most popular works were:

  • Crosstalk between diabetes and brain: Glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration (96 citations)
  • Pre-diabetes alters testicular PGC1-α/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress (95 citations)
  • Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers (69 citations)

In her most recent research, the most cited papers focused on:

  • Enzyme
  • Internal medicine
  • Mitochondrion

Maria S. Santos spends much of her time researching Internal medicine, Endocrinology, Mitochondrion, Insulin and Type 2 diabetes. Her research in Internal medicine intersects with topics in GSK-3 and Bioinformatics. Many of her research projects under Endocrinology are closely connected to Life quality and Adenine nucleotide with Life quality and Adenine nucleotide, tying the diverse disciplines of science together.

Her work carried out in the field of Mitochondrion brings together such families of science as Oxidative stress, Respiration and Streptozotocin. Her Oxidative stress study incorporates themes from Respiratory chain, Glutathione-disulfide reductase activity, Mitochondrial respiratory chain and Recurrent hypoglycemia. Within one scientific family, she focuses on topics pertaining to Neuroprotection under Insulin, and may sometimes address concerns connected to Glucose homeostasis.

Best Publications

  • Doxorubicin: The Good, the Bad and the Ugly Effect

    Cristina Carvalho;Renato X. Santos;Susana Cardoso;Sonia Correia

  • Carvedilol-mediated antioxidant protection against doxorubicin-induced cardiac mitochondrial toxicity

    Paulo J. Oliveira;James A. Bjork;Maria S. Santos;Richard L. Leino

  • Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes.

    Paula I. Moreira;Maria S. Santos;Raquel Seiça;Catarina R. Oliveira

  • Effects of hyperglycemia on sperm and testicular cells of Goto-Kakizaki and streptozotocin-treated rat models for diabetes

    Sandra Amaral;António J. Moreno;Maria Sancha Santos;Raquel Seiça

  • Lipoic Acid and N-acetyl Cysteine Decrease Mitochondrial-Related Oxidative Stress in Alzheimer Disease Patient Fibroblasts

    Paula I. Moreira;Peggy L.R. Harris;Xiongwei Zhu;Maria S. Santos

  • Insulin signaling, glucose metabolism and mitochondria: major players in Alzheimer's disease and diabetes interrelation.

    Sónia C Correia;Renato X Santos;Cristina Carvalho;Susana Cardoso

  • An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease.

    Paula I Moreira;Ana I Duarte;Maria S Santos;A Cristina Rego

  • Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: comparison with direct effects on isolated mitochondrial fractions.

    Gonçalo C. Pereira;Ana F. Branco;Júlio A.C. Matos;Sandro L. Pereira

  • Alzheimer disease and the role of free radicals in the pathogenesis of the disease.

    Paula I. Moreira;Maria S. Santos;Catarina R. Oliveira;Justin C. Shenk

  • Involvement of Oxidative Stress on the Impairment of Energy Metabolism Induced by Aβ Peptides on PC12 Cells: Protection by Antioxidants

    Cláudia Pereira;Maria Sancha Santos;Catarina Oliveira

  • Insulin is a Two-Edged Knife on the Brain

    Susana Cardoso;Sónia Correia;Renato X. Santos;Cristina Carvalho

  • The key role of mitochondria in Alzheimer's disease.

    P I Moreira;S M Cardoso;M S Santos;C R Oliveira

  • Increased autophagic degradation of mitochondria in Alzheimer disease.

    Paula I. Moreira;Paula I. Moreira;Sandra L. Siedlak;Xinglong Wang;Maria S. Santos

  • Alzheimer's disease: a lesson from mitochondrial dysfunction.

    Paula I. Moreira;Maria S. Santos;Catarina R. Oliveira

  • Crosstalk between diabetes and brain: Glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration

    A.I. Duarte;E. Candeias;S.C. Correia;R.X. Santos

  • Autophagocytosis of mitochondria is prominent in Alzheimer disease

    Paula I. Moreira;Paula I. Moreira;Sandra L. Siedlak;Xinglong Wang;Maria S. Santos

  • Metabolic Alterations Induced by Sucrose Intake and Alzheimer’s Disease Promote Similar Brain Mitochondrial Abnormalities

    Cristina Carvalho;Susana Cardoso;Sónia C. Correia;Renato X. Santos

  • Oxidative stress: the old enemy in Alzheimer's disease pathophysiology.

    Paula I. Moreira;Kazuhiro Honda;Quan Liu;Maria S. Santos

  • Effect of amyloid beta-peptide on permeability transition pore: A comparative study

    Paula I. Moreira;Maria S. Santos;António Moreno;A. Cristina Rego

  • Insulin neuroprotection against oxidative stress is mediated by Akt and GSK-3β signaling pathways and changes in protein expression

    Ana I. Duarte;Paulo Santos;Catarina R. Oliveira;Maria S. Santos

Frequent Co-Authors

Paula I. Moreira
Paula I. Moreira University of Coimbra
Catarina R. Oliveira
Catarina R. Oliveira University of Coimbra
António J.M. Moreno
António J.M. Moreno University of Coimbra
George Perry
George Perry The University of Texas at San Antonio
Paulo J. Oliveira
Paulo J. Oliveira University of Coimbra
Carlos M. Palmeira
Carlos M. Palmeira University of Coimbra
Mark A. Smith
Mark A. Smith Case Western Reserve University
Susana Cardoso
Susana Cardoso Instituto Superior Técnico
Xiongwei Zhu
Xiongwei Zhu Case Western Reserve University
Akihiko Nunomura
Akihiko Nunomura Jikei University School of Medicine

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