2026 Roger F. Castilho: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	57	13792	12689	68	67	157	12320

Overview

Roger F. Castilho is affiliated with the State University of Campinas in Brazil. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions to medicine. Within these broad fields, their work emphasizes molecular biology, physiology, clinical biochemistry, endocrinology, diabetes and metabolism, and cell biology.

Castilho's research covers a range of main topics, including:

Mitochondrial Function and Pathology
Adipose Tissue and Metabolism
ATP Synthase and ATPases Research
Metabolism and Genetic Disorders
Biochemical and Molecular Research
Cancer, Hypoxia, and Metabolism
Muscle metabolism and nutrition

Their recent publications include the following papers:

Mitochondrial NAD(P) ⁺ Transhydrogenase: From Molecular Features to Physiology and Disease, 2021, Antioxidants and Redox Signaling
Disturbance of bioenergetics and calcium homeostasis provoked by metabolites accumulating in propionic acidemia in heart mitochondria of developing rats, 2020, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Mitochondrial Physiology, 2020, HAL (Le Centre pour la Communication Scientifique Directe)
Mitochondrial NAD(P)+ Transhydrogenase is Unevenly Distributed in Different Brain Regions, and its Loss Causes Depressive-like Behavior and Motor Dysfunction in Mice, 2020, Neuroscience
NADPH supply and the contribution of NAD(P)+ transhydrogenase (NNT) to H2O2 balance in skeletal muscle mitochondria, 2021, Archives of Biochemistry and Biophysics

Frequent co-authors collaborating with Castilho include:

Annelise Francisco
Claudia D.C. Navarro
Aníbal E. Vercesi
Tiago R. Figueira
Juliana Silveira Ruas

The scientist's publications are often found in several notable venues such as:

Biochimica et Biophysica Acta (BBA) - Bioenergetics
Archives of Biochemistry and Biophysics
International Journal of Molecular Sciences
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

Mitochondria and reactive oxygen species.

Alicia Juliana Kowaltowski;Nadja Cristhina de Souza-Pinto;Roger Frigério Castilho;Anibal Eugenio Vercesi

1268
Citations
Mitochondrial permeability transition and oxidative stress.

Alicia J. Kowaltowski;Roger F. Castilho;Anibal E. Vercesi

1017
Citations
Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma.

Gustav Mattiasson;Mehrdad Shamloo;Gunilla Gido;Kavitha Mathi

621
Citations
Mitochondria as a Source of Reactive Oxygen and Nitrogen Species: From Molecular Mechanisms to Human Health

Tiago R Figueira;Mario H Barros;Anamaria A Camargo;Roger F Castilho

441
Citations
Improving the survival of grafted dopaminergic neurons: a review over current approaches

Patrik Brundin;Jenny Karlsson;Mia Emgård;Gabriele S. Kaminski Schierle

435
Citations
The role of reactive oxygen species in mitochondrial permeability transition

Anibal E. Vercesi;Alicia J. Kowaltowski;Mercedes T. Grijalba;André R. Meinicke

388
Citations
Opening of the mitochondrial permeability transition pore by uncoupling or inorganic phosphate in the presence of Ca2+ is dependent on mitochondrial-generated reactive oxygen species

Alicia J. Kowaltowski;Roger F. Castilho;Anibal E. Vercesi

357
Citations
Permeabilization of the inner mitochondrial membrane by Ca2+ ions is stimulated by t-butyl hydroperoxide and mediated by reactive oxygen species generated by mitochondria

Roger F. Castilho;Alicia J. Kowaltowski;AndréR. Meinicke;Etelvino J.H. Bechara

296
Citations
A spontaneous mutation in the nicotinamide nucleotide transhydrogenase gene of C57BL/6J mice results in mitochondrial redox abnormalities.

Juliana A. Ronchi;Tiago R. Figueira;Felipe G. Ravagnani;Helena C.F. Oliveira

274
Citations
Transgenic mice expressing a Huntington’s disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity

Oskar Hansson;Åsa Petersén;Marcel Leist;Pierluigi Nicotera

267
Citations
Mitochondrial membrane potential and hydroethidine-monitored superoxide generation in cultured cerebellar granule cells

Samantha L. Budd;Roger F. Castilho;David G. Nicholls

262
Citations
Effect of inorganic phosphate concentration on the nature of inner mitochondrial membrane alterations mediated by Ca2+ ions. A proposed model for phosphate-stimulated lipid peroxidation.

Alicia J. Kowaltowski;Roger F. Castilho;Mercedes T. Grijalba;Etelvino J.H. Bechara

244
Citations
Mitochondrial Control of Acute Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

Roger F. Castilho;Oskar Hansson;Manus W. Ward;Samantha L. Budd

231
Citations
Resistance to NMDA toxicity correlates with appearance of nuclear inclusions, behavioural deficits and changes in calcium homeostasis in mice transgenic for exon 1 of the huntington gene.

Oskar Hansson;Ezia Guatteo;Nicola B. Mercuri;Giorgio Bernardi

221
Citations
Oxidative stress, mitochondrial function, and acute glutamate excitotoxicity in cultured cerebellar granule cells.

Roger F. Castilho;Manus W. Ward;David G. Nicholls

216
Citations
Ca(2+)-induced mitochondrial membrane permeabilization: role of coenzyme Q redox state

A. J. Kowaltowski;R. F. Castilho;A. E. Vercesi

198
Citations
Oxidative stress in Ca2+-induced membrane permeability transition in brain mitochondria

Evelise N. Maciel;Anibal E. Vercesi;Roger F. Castilho

193
Citations
Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression.

Oskar Hansson;Jesper Nylandsted;Roger F. Castilho;Marcel Leist

156
Citations
Ca2+-induced oxidative stress in brain mitochondria treated with the respiratory chain inhibitor rotenone

Solange C. Sousa;Evelise N. Maciel;Anibal E. Vercesi;Roger F. Castilho

136
Citations
Ca2+-stimulated mitochondrial reactive oxygen species generation and permeability transition are inhibited by dibucaine or Mg2+.

Alicia J. Kowaltowski;Evandro S. Naia-da-Silva;Roger F. Castilho;Anibal E. Vercesi

133
Citations