World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
44
Citations
14066
World Ranking
19199
National Ranking
7841

Overview

Rama Ranganathan is affiliated with the University of Chicago in the United States. Their research spans multiple fields within life sciences, chiefly Biochemistry, Genetics, and Molecular Biology, with notable contributions also in Medicine.

The scientist's work covers a variety of subfields, including Molecular Biology, Materials Chemistry, Oncology, Cancer Research, and Genetics. Their research topics focus particularly on Protein Structure and Dynamics, RNA and protein synthesis mechanisms, Enzyme Structure and Function, Breast Cancer Treatment Studies, Advanced Breast Cancer Therapies, Microbial Metabolic Engineering and Bioproduction, and Evolution and Genetic Dynamics.

Ranganathan has published numerous recent papers, demonstrating active engagement across different journals and research areas. Notable publications include:

  • "An evolution-based model for designing chorismate mutase enzymes," 2020, Science
  • "Cancer survival in Africa, central and south America, and Asia (SURVCAN-3): a population-based benchmarking study in 32 countries," 2023, The Lancet Oncology
  • "100th Anniversary of Macromolecular Science Viewpoint: Data-Driven Protein Design," 2021, ACS Macro Letters
  • "Roadmap on biology in time varying environments," 2021, Physical Biology
  • "ProT-VAE: Protein Transformer Variational AutoEncoder for Functional Protein Design," 2023, bioRxiv (Cold Spring Harbor Laboratory)

Their frequent coauthors include Andrew L. Ferguson, Eugene Klyshko, Lauren McGough, Sarah Rauscher, and Manikandan Dhanushkodi. The collaboration with these researchers indicates sustained interdisciplinary cooperative efforts within the scientific community.

The researcher regularly publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Structural Dynamics, Biophysical Journal, Zenodo (CERN European Organization for Nuclear Research), and SSRN Electronic Journal. These outlets reflect an emphasis on both preprint and peer-reviewed platforms for disseminating scientific findings.

Best Publications

  • Evolutionarily conserved pathways of energetic connectivity in protein families.

    Steve W. Lockless;Rama Ranganathan

  • Evolutionarily conserved networks of residues mediate allosteric communication in proteins

    Gürol M. Süel;Steve W. Lockless;Mark A. Wall;Rama Ranganathan

  • Structural and Functional Analysis of the Mitotic Rotamase Pin1 Suggests Substrate Recognition Is Phosphorylation Dependent

    Rama Ranganathan;Kun Ping Lu;Kun Ping Lu;Tony Hunter;Joseph P. Noel

  • Protein sectors: evolutionary units of three-dimensional structure.

    Najeeb Halabi;Olivier Rivoire;Stanislas Leibler;Rama Ranganathan

  • Evolutionary information for specifying a protein fold.

    Michael Socolich;Michael Socolich;Steve W. Lockless;Steve W. Lockless;Steve W. Lockless;William P. Russ;Heather Lee;Heather Lee

  • The spatial architecture of protein function and adaptation

    Richard N. McLaughlin;Franciscus J Poelwijk;Arjun Raman;Walraj S. Gosal

  • The structural basis for red fluorescence in the tetrameric GFP homolog DsRed.

    Mark A. Wall;Michael Socolich;Rama Ranganathan

  • Hot spots for allosteric regulation on protein surfaces.

    Kimberly A. Reynolds;Richard N. McLaughlin;Rama Ranganathan

  • Arrestin function in inactivation of G protein-coupled receptor rhodopsin in vivo

    Patrick J. Dolph;Rama Ranganathan;Nansi J. Colley;Robert W. Hardy

  • Surface Sites for Engineering Allosteric Control in Proteins

    Jeeyeon Lee;Madhusudan Natarajan;Vishal C. Nashine;Michael Socolich

  • Structural Determinants of Allosteric Ligand Activation in RXR Heterodimers

    Andrew I Shulman;Christopher Larson;David J Mangelsdorf;Rama Ranganathan

  • Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis.

    Rama Ranganathan;John H Lewis;Roderick MacKinnon

  • An evolution-based model for designing chorismate mutase enzymes.

    William P. Russ;Matteo Figliuzzi;Christian Stocker;Pierre Barrat-Charlaix;Pierre Barrat-Charlaix

  • Natural-like function in artificial WW domains

    William P. Russ;Drew M. Lowery;Prashant Mishra;Michael B. Yaffe

  • Evolvability as a function of purifying selection in TEM-1 β-lactamase.

    Michael A. Stiffler;Doeke R. Hekstra;Rama Ranganathan

  • Photoreceptor deactivation and retinal degeneration mediated by a photoreceptor-specific protein kinase C.

    Dean P. Smith;Rama Ranganathan;Robert W. Hardy;Julia Marx

  • A global analysis of cross-talk in a mammalian cellular signalling network

    Madhusudan Natarajan;Keng Mean Lin;Robert C. Hsueh;Paul C. Sternweis

  • A molecular pathway for light-dependent photoreceptor apoptosis in Drosophila.

    Alexander Kiselev;Michael Socolich;Michael Socolich;Javier Vinós;Robert W. Hardy;Robert W. Hardy

  • Signal Transduction in Drosophila Photoreceptors

    Rama Ranganathan;Denise M. Malicki;Charles S. Zuker

  • PDZ domain proteins: Scaffolds for signaling complexes

    Rama Ranganathan;Elliott M Ross

Frequent Co-Authors

Charles S. Zuker
Charles S. Zuker Columbia University
John Kuriyan
John Kuriyan Vanderbilt University
Stanislas Leibler
Stanislas Leibler Rockefeller University
Arthur Weiss
Arthur Weiss University of California, San Francisco
Alfred G. Gilman
Alfred G. Gilman The University of Texas Southwestern Medical Center
David J. Mangelsdorf
David J. Mangelsdorf The University of Texas Southwestern Medical Center
Paul C. Sternweis
Paul C. Sternweis The University of Texas Southwestern Medical Center
Roger Y. Tsien
Roger Y. Tsien University of California, San Diego

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