World's Best Scientists 2026 revealed!
Makoto Makishima

Makoto Makishima

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
26918
World Ranking
15883
National Ranking
1135

Makoto Makishima publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Makoto Makishima sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 309 publications — 80th percentile

80% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Makoto Makishima D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Makoto Makishima sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 53 D-Index — 19th percentile

19% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Makoto Makishima is affiliated with Nihon University in Japan and has contributed extensively to research in Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans numerous subfields including Molecular Biology, Materials Chemistry, Immunology, Surgery, and Genetics.

Makishima's research frequently addresses topics related to Crystallization and Solubility Studies, X-ray Diffraction in Crystallography, Vitamin D Research Studies, Cholesterol and Lipid Metabolism, Estrogen and related hormone effects, Mesenchymal stem cell research, and Inflammasome and immune disorders.

Makishima has published papers in a variety of venues, with a notable concentration in:

  • The Cambridge Structural Database
  • International Journal of Molecular Sciences
  • Biomolecules
  • Scientific Reports
  • Biochemical and Biophysical Research Communications

Frequent collaborators include Yuichi Hashimoto, Minoru Ishikawa, Yūki Ichikawa, Masanobu Uchiyama, and Michiaki Hiramatsu.

Selected recent papers authored or co-authored by Makishima include:

  • "Molecular Basis of Bile Acid-FXR-FGF15/19 Signaling Axis" (2022), published in International Journal of Molecular Sciences
  • "Myeloid LXR (Liver X Receptor) Deficiency Induces Inflammatory Gene Expression in Foamy Macrophages and Accelerates Atherosclerosis" (2022), published in Arteriosclerosis Thrombosis and Vascular Biology
  • "Dec1 deficiency protects the heart from fibrosis, inflammation, and myocardial cell apoptosis in a mouse model of cardiac hypertrophy" (2020), published in Biochemical and Biophysical Research Communications
  • "MicroRNA-21 facilitates osteoblast activity" (2020), published in Biochemistry and Biophysics Reports
  • "A deficiency of Dec2 triggers periodontal inflammation and pyroptosis" (2021), published in Journal of Periodontal Research

These publications indicate a focus on molecular signaling pathways, inflammatory gene expression, cardiac and bone cellular activity, and immune-related cellular processes.

Best Publications

  • Increased oxidative stress in obesity and its impact on metabolic syndrome

    Shigetada Furukawa;Takuya Fujita;Michio Shimabukuro;Masanori Iwaki

  • Identification of a Nuclear Receptor for Bile Acids

    Makoto Makishima;Arthur Y. Okamoto;Joyce J. Repa;Hua Tu

  • Visfatin: a protein secreted by visceral fat that mimics the effects of insulin.

    Atsunori Fukuhara;Morihiro Matsuda;Masako Nishizawa;Katsumori Segawa

  • Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors.

    Timothy T. Lu;Makoto Makishima;Joyce J. Repa;Kristina Schoonjans

  • Vitamin D Receptor As an Intestinal Bile Acid Sensor

    Makoto Makishima;Timothy T. Lu;Wen Xie;G. Kerr Whitfield

  • Induction of Adiponectin, a Fat-Derived Antidiabetic and Antiatherogenic Factor, by Nuclear Receptors

    Masanori Iwaki;Morihiro Matsuda;Norikazu Maeda;Tohru Funahashi

  • Human Bile Salt Export Pump Promoter Is Transactivated by the Farnesoid X Receptor/Bile Acid Receptor

    Meenakshisundaram Ananthanarayanan;Natarajan V. Balasubramanian;Makoto Makishima;David J. Mangelsdorf

  • The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp.

    Lee A. Denson;Ekkehard Sturm;Wihelma Echevarria;Tracy L. Zimmerman

  • The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway

    Keith D. Baker;Lisa M. Shewchuk;Tatiana Kozlova;Makoto Makishima;Makoto Makishima

  • Induction of Intestinal ATP-binding Cassette Transporters by a Phytosterol-derived Liver X Receptor Agonist

    Emi Kaneko;Morihiro Matsuda;Yukio Yamada;Yoji Tachibana

  • Musclin, a novel skeletal muscle-derived secretory factor.

    Hitoshi Nishizawa;Hitoshi Nishizawa;Morihiro Matsuda;Morihiro Matsuda;Yukio Yamada;Kenichiro Kawai

  • Selective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative

    Ryutaro Adachi;Yoshio Honma;Hiroyuki Masuno;Katsuyoshi Kawana;Katsuyoshi Kawana

  • Nuclear receptors as targets for drug development: regulation of cholesterol and bile acid metabolism by nuclear receptors.

    Makoto Makishima

  • Angiopoietin-like protein 3 mediates hypertriglyceridemia induced by the liver X receptor

    Toshimori Inaba;Morihiro Matsuda;Morihiro Matsuda;Mitsuru Shimamura;Norihide Takei

  • Diosgenin, the Main Aglycon of Fenugreek, Inhibits LXRα Activity in HepG2 Cells and Decreases Plasma and Hepatic Triglycerides in Obese Diabetic Mice

    Taku Uemura;Tsuyoshi Goto;Min‑Sook Kang;Noriko Mizoguchi

  • Sulfonylurea Agents Exhibit Peroxisome Proliferator-activated Receptor γ Agonistic Activity

    Shuichi Fukuen;Masanori Iwaki;Atsutaka Yasui;Makoto Makishima

  • Angiopoietin-like protein 3, a hepatic secretory factor, activates lipolysis in adipocytes.

    Mitsuru Shimamura;Morihiro Matsuda;Sachiko Kobayashi;Yosuke Ando

  • Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia.

    Michiyasu Ishizawa;Manabu Matsunawa;Ryutaro Adachi;Shigeyuki Uno

  • Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARγ pathway

    Masanobu Kawai;Noriyuki Namba;Sotaro Mushiake;Yuri Etani

  • Visfatin : A protein secreted by visceral fat that mimics the effects of insulin

    Atsunori Fukuhara;Morihiro Matsuda;Masako Nishizawa;Katsumori Segawa

Frequent Co-Authors

Yuichi Hashimoto
Yuichi Hashimoto University of Tokyo
Kazuo Motoyoshi
Kazuo Motoyoshi National Defense Medical College
David J. Mangelsdorf
David J. Mangelsdorf The University of Texas Southwestern Medical Center
Iichiro Shimomura
Iichiro Shimomura Osaka University
Yoshimichi Ohki
Yoshimichi Ohki Waseda University
Chisei Ra
Chisei Ra Nihon University
Yukio Kato
Yukio Kato Hiroshima University
Takeshi Kawamoto
Takeshi Kawamoto Hiroshima University
Mitsuhide Noshiro
Mitsuhide Noshiro Hiroshima University
Daniel W. Nebert
Daniel W. Nebert University of Cincinnati

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