His main research concerns Biochemistry, Nuclear receptor, Internal medicine, Endocrinology and Bile acid. His work carried out in the field of Biochemistry brings together such families of science as Molecular biology and Cell biology. His Nuclear receptor research is multidisciplinary, incorporating perspectives in Calcitriol receptor, Receptor, Signal transduction and Coactivator.
His work on Myocyte, Glimepiride and Thyroid hormone receptor as part of general Endocrinology study is frequently linked to C2C12 and Signal peptide, bridging the gap between disciplines. His work is dedicated to discovering how Adipose tissue, Adipokine are connected with Oxidative stress, NADPH oxidase, Metabolic syndrome, Reactive oxygen species and Steatosis and other disciplines. His G protein-coupled bile acid receptor research includes themes of Farnesoid X receptor and Cholestasis.
Makoto Makishima spends much of his time researching Biochemistry, Nuclear receptor, Internal medicine, Calcitriol receptor and Receptor. His Nuclear receptor research incorporates themes from Coactivator, Transactivation, Signal transduction, Steroid and Pharmacology. The study incorporates disciplines such as Gastroenterology, Endocrinology and Oncology in addition to Internal medicine.
Adipose tissue and Insulin are the primary areas of interest in his Endocrinology study. His work deals with themes such as Calcium metabolism and Lithocholic acid, Bile acid, which intersect with Calcitriol receptor. His work investigates the relationship between Receptor and topics such as Liver X receptor that intersect with problems in Cell biology, Transrepression and Lipid metabolism.
Makoto Makishima focuses on Internal medicine, Calcitriol receptor, Receptor, Liver X receptor and Cell biology. His Internal medicine research is multidisciplinary, incorporating elements of Gastroenterology, Endocrinology and Oncology. As a member of one scientific family, Makoto Makishima mostly works in the field of Endocrinology, focusing on Immune system and, on occasion, Cytokine.
The various areas that Makoto Makishima examines in his Calcitriol receptor study include Calcium metabolism, Lithocholic acid and Molecular biology. Receptor is a subfield of Biochemistry that he investigates. His Liver X receptor study necessitates a more in-depth grasp of Nuclear receptor.
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Increased oxidative stress in obesity and its impact on metabolic syndrome
Shigetada Furukawa;Takuya Fujita;Michio Shimabukuro;Masanori Iwaki.
Journal of Clinical Investigation (2004)
Identification of a Nuclear Receptor for Bile Acids
Makoto Makishima;Arthur Y. Okamoto;Joyce J. Repa;Hua Tu.
Visfatin: a protein secreted by visceral fat that mimics the effects of insulin.
Atsunori Fukuhara;Morihiro Matsuda;Masako Nishizawa;Katsumori Segawa.
Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors.
Timothy T. Lu;Makoto Makishima;Joyce J. Repa;Kristina Schoonjans.
Molecular Cell (2000)
Vitamin D Receptor As an Intestinal Bile Acid Sensor
Makoto Makishima;Timothy T. Lu;Wen Xie;G. Kerr Whitfield.
Induction of Adiponectin, a Fat-Derived Antidiabetic and Antiatherogenic Factor, by Nuclear Receptors
Masanori Iwaki;Morihiro Matsuda;Norikazu Maeda;Tohru Funahashi.
Human Bile Salt Export Pump Promoter Is Transactivated by the Farnesoid X Receptor/Bile Acid Receptor
Meenakshisundaram Ananthanarayanan;Natarajan V. Balasubramanian;Makoto Makishima;David J. Mangelsdorf.
Journal of Biological Chemistry (2001)
The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp.
Lee A. Denson;Ekkehard Sturm;Wihelma Echevarria;Tracy L. Zimmerman.
The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway
Keith D. Baker;Lisa M. Shewchuk;Tatiana Kozlova;Makoto Makishima;Makoto Makishima.
Induction of Intestinal ATP-binding Cassette Transporters by a Phytosterol-derived Liver X Receptor Agonist
Emi Kaneko;Morihiro Matsuda;Yukio Yamada;Yoji Tachibana.
Journal of Biological Chemistry (2003)
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