Yuichi Hashimoto

Overview

Best Publications

• A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ

  Yuichi Hashimoto;Takako Niikura;Hirohisa Tajima;Takashi Yasukawa

  746
  Citations

• Improvement in Aqueous Solubility in Small Molecule Drug Discovery Programs by Disruption of Molecular Planarity and Symmetry

  Minoru Ishikawa;Yuichi Hashimoto

  741
  Citations

• Protein knockdown using methyl bestatin-ligand hybrid molecules: design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins.

  Yukihiro Itoh;Minoru Ishikawa;Mikihiko Naito;Yuichi Hashimoto

  467
  Citations

• Retinoic acid receptor beta mediates the growth-inhibitory effect of retinoic acid by promoting apoptosis in human breast cancer cells.

  Yi Liu;Mi-Ock Lee;Hong-Gang Wang;Yin Li

  461
  Citations

• Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity.

  Kagechika H;Kawachi E;Hashimoto Y;Himi T

  390
  Citations

• Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis.

  Maaria Ikonen;Bingrong Liu;Yuichi Hashimoto;Liqun Ma

  386
  Citations

• Development of bis-thiourea-type organocatalyst for asymmetric Baylis–Hillman reaction

  Yoshihiro Sohtome;Aya Tanatani;Yuichi Hashimoto;Kazuo Nagasawa

  322
  Citations

• Guanidine-Thiourea Bifunctional Organocatalyst for the Asymmetric Henry (Nitroaldol) Reaction

  Yoshihiro Sohtome;Yuichi Hashimoto;Kazuo Nagasawa

  292
  Citations

• Detailed Characterization of Neuroprotection by a Rescue Factor Humanin against Various Alzheimer's Disease-Relevant Insults

  Yuichi Hashimoto;Takako Niikura;Yuko Ito;Haruka Sudo

  284
  Citations

• The Peroxisome Proliferator-Activated Receptor γ/Retinoid X Receptor α Heterodimer Targets the Histone Modification Enzyme PR-Set7/Setd8 Gene and Regulates Adipogenesis through a Positive Feedback Loop

  Ken Ichi Wakabayashi;Masashi Okamura;Shuichi Tsutsumi;Naoko S. Nishikawa

  277
  Citations

• Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.

  Hiroki Umemiya;Hiroshi Fukasawa;Masayuki Ebisawa;Laurence Eyrolles

  268
  Citations

• Humanin Inhibits Neuronal Cell Death by Interacting with a Cytokine Receptor Complex or Complexes Involving CNTF Receptor α/WSX-1/gp130

  Yuichi Hashimoto;Megumi Kurita;Sadakazu Aiso;Ikuo Nishimoto

  253
  Citations

• Novel Biological Response Modifiers: Phthalimides with Tumor Necrosis Factor-α Production-Regulating Activity

  Hiroyuki Miyachi;Akihiko Azuma;Asuka Ogasawara;Eiji Uchimura

  217
  Citations

• C2‐Symmetric Chiral Pentacyclic Guanidine: A Phase‐Transfer Catalyst for the Asymmetric Alkylation of tert‐Butyl Glycinate Schiff Base

  Tetsuya Kita;Angelina Georgieva;Yuichi Hashimoto;Tadashi Nakata

  208
  Citations

• Diastereoselective and Enantioselective Henry (Nitroaldol) Reaction Utilizing a Guanidine-Thiourea Bifunctional Organocatalyst

  Yoshihiro Sohtome;Yuichi Hashimoto;Kazuo Nagasawa

  205
  Citations

• Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults

  Hirohisa Tajima;Takako Niikura;Yuichi Hashimoto;Yuko Ito

  190
  Citations

• Dye Sensitized Solar Cell (DSSC) greenhouse shading: New insights for solar radiation manipulation

  N. Roslan;M.E. Ya'acob;M.A.M. Radzi;Y. Hashimoto

  190
  Citations

• Glyoxalase I is involved in resistance of human leukemia cells to antitumor agent-induced apoptosis.

  Hiroshi Sakamoto;Tetsuo Mashima;Atsuo Kizaki;Shingo Dan

  190
  Citations

• Structural development of biological response modifiers based on thalidomide.

  Yuichi Hashimoto

  178
  Citations

• Design, synthesis and biological evaluation of nuclear receptor-degradation inducers.

  Yukihiro Itoh;Risa Kitaguchi;Minoru Ishikawa;Mikihiko Naito

  176
  Citations

• Progress in the medicinal chemistry of silicon: C/Si exchange and beyond.

  Shinya Fujii;Yuichi Hashimoto

  174
  Citations

• Direct ortho cupration: a new route to regioselectively functionalized aromatics.

  Shinya Usui;Yuichi Hashimoto;James V. Morey;Andrew E. H. Wheatley

  168
  Citations

• Chemistry of biologically active benzoxazinoids

  Yuichi Hashimoto;Koichi Shudo

  160
  Citations

• Novel non-steroidal/non-anilide type androgen antagonists with an isoxazolone moiety.

  Toshiyasu Ishioka;Asako Kubo;Yukiko Koiso;Kazuo Nagasawa

  158
  Citations

• Identification of a Novel Class of Retinoic Acid Receptor β-Selective Retinoid Antagonists and Their Inhibitory Effects on AP-1 Activity and Retinoic Acid-induced Apoptosis in Human Breast Cancer Cells

  Yin Li;Yuichi Hashimoto;Anissa Agadir;Hiroyuki Kagechika

  149
  Citations

• Crystal Structure of Vigna radiata Cytokinin-Specific Binding Protein in Complex with Zeatin

  Oliwia Pasternak;Grzegorz D. Bujacz;Grzegorz D. Bujacz;Yasuyuki Fujimoto;Yuichi Hashimoto

  145
  Citations

• Retinobenzoic acids. 3. Structure-activity relationships of retinoidal azobenzene-4-carboxylic acids and stilbene-4-carboxylic acids.

  Hiroyuki Kagechika;Toshiyuki Himi;Koushi Namikawa;Emiko Kawachi

  139
  Citations

• Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein.

  Keiichiro Okuhira;Nobumichi Ohoka;Kimie Sai;Tomoko Nishimaki-Mogami

  133
  Citations

• Novel biological response modifiers derived from thalidomide.

  Hashimoto Y

  133
  Citations

• PURIFICATION AND CDNA CLONING OF CYTOKININ-SPECIFIC BINDING PROTEIN FROM MUNG BEAN (VIGNA RADIATA)

  Yasuyuki Fujimoto;Ryuji Nagata;Hiroshi Fukasawa;Keiichi Yano

  131
  Citations