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Mikihiko Naito

Mikihiko Naito

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
16383
World Ranking
6388
National Ranking
413

Overview

Mikihiko Naito is affiliated with the University of Tokyo in Japan and has made contributions primarily in the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine. Their research encompasses a range of subfields including Molecular Biology, Oncology, Hematology, Cell Biology, and Cancer Research.

The main areas of scientific inquiry for Mikihiko Naito include Protein Degradation and Inhibitors, Ubiquitin and proteasome pathways, Peptidase Inhibition and Analysis, Multiple Myeloma Research and Treatments, CAR-T cell therapy research, Histone Deacetylase Inhibitors Research, and Advanced biosensing and bioanalysis techniques.

Some of the notable recent papers authored or co-authored include:

  • Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy, 2020, The Journal of Cell Biology
  • TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains, 2021, Molecular Cell
  • Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells, 2020, Oncogene
  • Targeting CRABP-II overcomes pancreatic cancer drug resistance by reversing lipid raft cholesterol accumulation and AKT survival signaling, 2022, Journal of Experimental & Clinical Cancer Research
  • cIAP1-based degraders induce degradation via branched ubiquitin architectures, 2022, Nature Chemical Biology

Frequent co-authors collaborating with Mikihiko Naito include:

  • Yosuke Demizu
  • Nobumichi Ohoka
  • Hidetomo Yokoo
  • Genichiro Tsuji
  • Takao Inoué

The scientist's work has been published repeatedly in venues such as:

  • ACS Medicinal Chemistry Letters
  • Bioorganic & Medicinal Chemistry
  • Proceedings for Annual Meeting of The Japanese Pharmacological Society
  • Pharmaceuticals
  • The Journal of Biochemistry

Best Publications

  • Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal.

    Takashi Tsuruo;Mikihiko Naito;Akihiro Tomida;Naoya Fujita

  • Functional involvement of P-glycoprotein in blood-brain barrier

    T Tatsuta;M Naito;T Oh-hara;I Sugawara

  • Protein knockdown using methyl bestatin-ligand hybrid molecules: design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins.

    Yukihiro Itoh;Minoru Ishikawa;Mikihiko Naito;Yuichi Hashimoto

  • Brain pericytes contribute to the induction and up-regulation of blood–brain barrier functions through transforming growth factor-β production

    Shinya Dohgu;Fuyuko Takata;Atsushi Yamauchi;Shinsuke Nakagawa

  • The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier.

    Takashi Kageyama;Masaru Nakamura;Akinori Matsuo;Yasuomi Yamasaki

  • Actin cleavage by CPP-32/apopain during the development of apoptosis

    Tetsuo Mashima;Mikihiko Naito;Kohji Noguchi;Douglas K. Miller

  • Brain Capillary Endothelial Cells Express two forms of Erythropoietin Receptor mRNA

    Ryoichi Yamaji;Tadayuki Okada;Maki Moriya;Mikihiko Naito

  • Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function

    Yanyan Hao;Keiko Sekine;Atsushi Kawabata;Hitoshi Nakamura;Hitoshi Nakamura

  • Identification of actin as a substrate of ICE and an ICE-like protease and involvement of an ICE-like protease but not ICE in VP-16-induced U937 apoptosis.

    Tetsuo Mashima;Mikihiko Naito;Naoya Fujita;Kohji Noguchi

  • In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs).

    Nobumichi Ohoka;Keiichiro Okuhira;Masahiro Ito;Katsunori Nagai

  • APOXIN I, A NOVEL APOPTOSIS-INDUCING FACTOR WITH L-AMINO ACID OXIDASE ACTIVITY PURIFIED FROM WESTERN DIAMONDBACK RATTLESNAKE VENOM

    Shinichi Torii;Shinichi Torii;Mikihiko Naito;Takashi Tsuruo;Takashi Tsuruo

  • ASK1 mediates apoptotic cell death induced by genotoxic stress

    Zhihong Chen;Hiroyuki Seimiya;Mikihiko Naito;Tetsuo Mashima

  • Effect of bioflavonoids on vincristine transport across blood-brain barrier.

    Yoshiharu Mitsunaga;Hitomi Takanaga;Hirotami Matsuo;Mikihiko Naito

  • Aspartate-Based Inhibitor of Interleukin-1β-Converting Enzyme Prevents Antitumor Agent-Induced Apoptosis in Human Myeloid Leukemia U937 Cells

    T. Mashima;M. Naito;S. Kataoka;H. Kawai

  • Small Molecules Destabilize cIAP1 by Activating Auto-ubiquitylation

    Keiko Sekine;Kohei Takubo;Ryo Kikuchi;Michie Nishimoto

  • Selective induction of apoptosis in Philadelphia chromosome-positive chronic myelogenous leukemia cells by an inhibitor of BCR–ABL tyrosine kinase, CGP 57148

    Shingo Dan;Mikihiko Naito;Takashi Tsuruo;Takashi Tsuruo

  • Design, synthesis and biological evaluation of nuclear receptor-degradation inducers.

    Yukihiro Itoh;Risa Kitaguchi;Minoru Ishikawa;Mikihiko Naito

  • Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands

    Norihito Shibata;Katsunori Nagai;Yoko Morita;Osamu Ujikawa

  • Comparative Study on Reversal Efficacy of SDZ PSC 833, Cyclosporin a and Verapamil on Multidrug Resistance in vitro and in vivo

    Toru Watanabe;Harumi Tsuge;Tomoko Oh-Hara;Mikihiko Naito

  • Phosphatidylserine Externalization Is a Downstream Event of Interleukin-1β–Converting Enzyme Family Protease Activation During Apoptosis

    Mikihiko Naito;Mikihiko Naito;Kimie Nagashima;Kimie Nagashima;Tetsuo Mashima;Tetsuo Mashima;Takashi Tsuruo;Takashi Tsuruo

Frequent Co-Authors

Takashi Tsuruo
Takashi Tsuruo Japanese Foundation For Cancer Research
Takashi Tsuruo
Takashi Tsuruo Japanese Foundation For Cancer Research
Naoya Fujita
Naoya Fujita Japanese Foundation For Cancer Research
Yuichi Hashimoto
Yuichi Hashimoto University of Tokyo
Ichiro Kudo
Ichiro Kudo Showa University
Keizo Inoue
Keizo Inoue University of Tokyo
Yuichi Sugiyama
Yuichi Sugiyama University of Tokyo
Hiroshi Suzuki
Hiroshi Suzuki Obihiro University of Agriculture and Veterinary Medicine
John C. Reed
John C. Reed Johnson & Johnson (United States)
Yoshiro Saito
Yoshiro Saito Tohoku University

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