His scientific interests lie mostly in Cell biology, Biochemistry, Apoptosis, Molecular biology and P-glycoprotein. His research integrates issues of Inhibitor of apoptosis, Cancer therapy, Ubiquitin and Mutagenesis in his study of Cell biology. His Biochemistry course of study focuses on Biophysics and Intracellular.
His Apoptosis research is multidisciplinary, incorporating elements of Proteases, Cancer research and Protease. The various areas that Mikihiko Naito examines in his Molecular biology study include Receptor, Phosphoprotein, Cell fractionation and Transfection. His research in P-glycoprotein intersects with topics in Endothelial stem cell, Vasculogenesis, Blood–brain barrier and Pharmacology.
Mikihiko Naito mainly focuses on Cell biology, Biochemistry, Molecular biology, Cancer research and Pharmacology. His Cell biology research integrates issues from Ubiquitin, Ubiquitin ligase, Downregulation and upregulation and Cytosol. He works mostly in the field of Biochemistry, limiting it down to topics relating to Biophysics and, in certain cases, Intracellular, as a part of the same area of interest.
As a part of the same scientific family, Mikihiko Naito mostly works in the field of Molecular biology, focusing on Apoptosis and, on occasion, Proteases, Cancer cell, Monocytic leukemia and Tumor necrosis factor alpha. Mikihiko Naito interconnects P-glycoprotein, Multiple drug resistance and Cyclosporin a in the investigation of issues within Pharmacology. His research in P-glycoprotein tackles topics such as Blood–brain barrier which are related to areas like Endothelial stem cell and Endothelium.
Mikihiko Naito spends much of his time researching Cell biology, Protein degradation, Ubiquitin ligase, Inhibitor of apoptosis and Biochemistry. His Cell biology study combines topics from a wide range of disciplines, such as Ubiquitin, Cytosol, Estrogen receptor, Philadelphia chromosome and Mitophagy. His work in Ubiquitin covers topics such as Androgen receptor which are related to areas like Protein–protein interaction, Coactivator and Molecular biology.
His studies deal with areas such as Gene knockdown, Target protein and Drug discovery as well as Ubiquitin ligase. His research on Inhibitor of apoptosis concerns the broader Apoptosis. Mikihiko Naito undertakes multidisciplinary investigations into Biochemistry and Amphiphile in his work.
His primary scientific interests are in XIAP, Inhibitor of apoptosis, Cell biology, Ubiquitin and Protein degradation. Mikihiko Naito combines subjects such as Cancer cell, Chronic myelogenous leukemia, Cancer research and Ubiquitin ligase with his study of XIAP. Ubiquitin ligase is a subfield of Biochemistry that he investigates.
His Inhibitor of apoptosis study contributes to a more complete understanding of Apoptosis. He has researched Apoptosis in several fields, including Protein ligand, Receptor, Molecular biology and Prostate cancer, Androgen receptor. His work carried out in the field of Cell biology brings together such families of science as Autophagy and ATG8.
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Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal.
Takashi Tsuruo;Mikihiko Naito;Akihiro Tomida;Naoya Fujita.
Cancer Science (2003)
Functional involvement of P-glycoprotein in blood-brain barrier
T Tatsuta;M Naito;T Oh-hara;I Sugawara.
Journal of Biological Chemistry (1992)
Brain pericytes contribute to the induction and up-regulation of blood–brain barrier functions through transforming growth factor-β production
Shinya Dohgu;Fuyuko Takata;Atsushi Yamauchi;Shinsuke Nakagawa.
Brain Research (2005)
Protein knockdown using methyl bestatin-ligand hybrid molecules: design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins.
Yukihiro Itoh;Minoru Ishikawa;Mikihiko Naito;Yuichi Hashimoto.
Journal of the American Chemical Society (2010)
Actin cleavage by CPP-32/apopain during the development of apoptosis
Tetsuo Mashima;Mikihiko Naito;Kohji Noguchi;Douglas K. Miller.
The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier.
Takashi Kageyama;Masaru Nakamura;Akinori Matsuo;Yasuomi Yamasaki.
Brain Research (2000)
Brain Capillary Endothelial Cells Express two forms of Erythropoietin Receptor mRNA
Ryoichi Yamaji;Tadayuki Okada;Maki Moriya;Mikihiko Naito.
FEBS Journal (1996)
Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function
Yanyan Hao;Keiko Sekine;Atsushi Kawabata;Hitoshi Nakamura;Hitoshi Nakamura.
Nature Cell Biology (2004)
Identification of Actin as a Substrate of ICE and an ICE-like Protease and Involvement of an ICE-like Protease but Not ICE in Vp-16-Induced U937 Apoptosis
Tetsuo Mashima;Mikihiko Naito;Naoya Fujita;Kohji Noguchi.
Biochemical and Biophysical Research Communications (1995)
APOXIN I, A NOVEL APOPTOSIS-INDUCING FACTOR WITH L-AMINO ACID OXIDASE ACTIVITY PURIFIED FROM WESTERN DIAMONDBACK RATTLESNAKE VENOM
Shinichi Torii;Shinichi Torii;Mikihiko Naito;Takashi Tsuruo;Takashi Tsuruo.
Journal of Biological Chemistry (1997)
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