World's Best Scientists 2026 revealed!
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Genetics and Molecular Biology
Japan
2024
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Medicine
Japan
2023

D-Index & Metrics

Molecular Biology

D-Index
134
Citations
57749
World Ranking
164
National Ranking
14

Medicine

D-Index
136
Citations
64995
World Ranking
1988
National Ranking
37

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in Japan Leader Award
  • 2023 - Research.com Medicine in Japan Leader Award

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Cancer

Molecular biology, Apoptosis, Cell culture, Cancer research and Cell biology are his primary areas of study. His Molecular biology research is multidisciplinary, incorporating elements of Cell, Camptothecin, Telomere, Monoclonal antibody and Telomerase reverse transcriptase. Takashi Tsuruo has researched Apoptosis in several fields, including Proteases and Enzyme.

His Cell culture research integrates issues from In vitro, Gene expression, Cancer cell, Immunology and Telomerase. His work deals with themes such as ASK1, Mitogen-activated protein kinase kinase, Cytotoxicity, Kinase and MAP kinase kinase kinase, which intersect with Cancer research. In his work, Serine/threonine-specific protein kinase and Phosphorylation cascade is strongly intertwined with Cyclin-dependent kinase 1, which is a subfield of Cell biology.

His most cited work include:

  • Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues (2446 citations)
  • Overcoming of Vincristine Resistance in P388 Leukemia in Vivo and in Vitro through Enhanced Cytotoxicity of Vincristine and Vinblastine by Verapamil (1343 citations)
  • Modulation of Akt kinase activity by binding to Hsp90 (809 citations)

What are the main themes of his work throughout his whole career to date?

His main research concerns Molecular biology, Cancer research, Cell culture, P-glycoprotein and In vitro. The Molecular biology study combines topics in areas such as Apoptosis, Biochemistry, DNA, Cell biology and Monoclonal antibody. His research in Cancer research intersects with topics in Endocrinology, Cancer cell, Internal medicine, Metastasis and Kinase.

His Cell culture study which covers Camptothecin that intersects with Topoisomerase. His P-glycoprotein study integrates concerns from other disciplines, such as Blood–brain barrier, Cyclosporin a, Immunology and Pharmacology. Takashi Tsuruo combines subjects such as Vincristine, Stereochemistry and In vivo with his study of In vitro.

He most often published in these fields:

  • Molecular biology (47.75%)
  • Cancer research (35.89%)
  • Cell culture (32.05%)

What were the highlights of his more recent work (between 2001-2011)?

  • Cell biology (27.88%)
  • Cancer research (35.89%)
  • Molecular biology (47.75%)

In recent papers he was focusing on the following fields of study:

Takashi Tsuruo focuses on Cell biology, Cancer research, Molecular biology, Biochemistry and Pharmacology. His Cell biology study frequently draws connections between adjacent fields such as Apoptosis. His work in Cancer research tackles topics such as Cancer cell which are related to areas like Metastasis.

His study on Molecular biology also encompasses disciplines like

  • Transfection which connect with Regulation of gene expression,
  • Cell culture which is related to area like Organic cation transport proteins. His research integrates issues of P-glycoprotein, Drug resistance, Multiple drug resistance, Chemotherapy and Efflux in his study of Pharmacology. His P-glycoprotein study deals with Immunology intersecting with Neurotoxicity.

Between 2001 and 2011, his most popular works were:

  • C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance. (389 citations)
  • C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance. (389 citations)
  • Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. (302 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Cancer

His primary scientific interests are in Cell biology, Molecular biology, Protein kinase B, Cancer research and Biochemistry. Takashi Tsuruo has included themes like Cyclin-dependent kinase 1 and Enzyme in his Cell biology study. His Molecular biology research is multidisciplinary, incorporating perspectives in Cell culture, Transfection, Targeted disruption, Efflux and Neonatal lethality.

His study in Protein kinase B is interdisciplinary in nature, drawing from both PI3K/AKT/mTOR pathway and Kinase, Kinase activity. His research investigates the link between Kinase and topics such as Dephosphorylation that cross with problems in 7-hydroxystaurosporine, Cytotoxicity, In vivo, Caspase and Ceramide. His studies deal with areas such as Endocrinology, Apoptosome, Cancer cell, Apoptosis and Internal medicine as well as Cancer research.

Best Publications

  • Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

    Franz Thiebaut;Takashi Tsuruo;Hirofumi Hamada;Michael M. Gottesman

  • Overcoming of Vincristine Resistance in P388 Leukemia in Vivo and in Vitro through Enhanced Cytotoxicity of Vincristine and Vinblastine by Verapamil

    Takashi Tsuruo;Harumi Iida;Shigeru Tsukagoshi;Yoshio Sakurai

  • Modulation of Akt kinase activity by binding to Hsp90

    Saori Sato;Naoya Fujita;Takashi Tsuruo

  • A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors

    Akiko Saito;Takashi Yamashita;Yukiyasu Mariko;Yasuhito Nosaka

  • Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors

    Takashi Tsuruo;Harumi Iida;Shigeru Tsukagoshi;Yoshio Sakurai

  • Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

    Rika Hoshino;Yuji Chatani;Takao Yamori;Takashi Tsuruo;Takashi Tsuruo

  • Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.

    Franz Thiebaut;Takashi Tsuruo;Hirofumi Hamada;Michael M. Gottesman

  • Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies.

    Hirofumi Hamada;Takashi Tsuruo

  • Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion

    Thomas C. Hamilton;Margaret A. Winker;Karen G. Louie;Gerald Batist

  • Clinical Significance of Multidrug Resistance P-Glycoprotein Expression on Acute Nonlymphoblastic Leukemia Cells at Diagnosis

    Lydia Campos;Denis Guyotat;Eric Archimbaud;Pascale Calmard-Oriol

  • Tissue Distribution of P-Glycoprotein Encoded by a Multidrug-resistant Gene as Revealed by a Monoclonal Antibody, MRK 16

    Isamu Sugawara;Iyo Kataoka;Yasuyuki Morishita;Hirofumi Hamada

  • C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance.

    Yasuo Imai;Minoru Nakane;Kumie Kage;Satomi Tsukahara

  • Circumvention of Vincristine and Adriamycin Resistance in Vitro and in Vivo by Calcium Influx Blockers

    Takashi Tsuruo;Harumi Iida;Makiko Nojiri;Shigeru Tsukagoshi

  • Role of aminopeptidase N (CD13) in tumor-cell invasion and extracellular matrix degradation

    Ikuo Saiki;Junya Yoneda;Ichiro Azuma;Hideji Fujii

  • Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.

    H Hamada;T Tsuruo

  • Domain Mapping Studies Reveal That the M Domain of hsp90 Serves as a Molecular Scaffold to Regulate Akt-Dependent Phosphorylation of Endothelial Nitric Oxide Synthase and NO Release

    Jason Fontana;David Fulton;Yan Chen;Todd A. Fairchild

  • Involvement of 14‐3‐3 proteins in nuclear localization of telomerase

    Hiroyuki Seimiya;Hiroyuki Seimiya;Hiroko Sawada;Yukiko Muramatsu;Mayuko Shimizu

  • Brain pericytes contribute to the induction and up-regulation of blood–brain barrier functions through transforming growth factor-β production

    Shinya Dohgu;Fuyuko Takata;Atsushi Yamauchi;Shinsuke Nakagawa

  • Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow

    Mika Shimonaka;Mika Shimonaka;Koko Katagiri;Toshinori Nakayama;Naoya Fujita

  • Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization.

    Naoya Fujita;Saori Sato;Kazuhiro Katayama;Takashi Tsuruo;Takashi Tsuruo

Frequent Co-Authors

Mikihiko Naito
Mikihiko Naito University of Tokyo
Naoya Fujita
Naoya Fujita Japanese Foundation For Cancer Research
Hirofumi Hamada
Hirofumi Hamada Sapporo Medical University
Yoshikazu Sugimoto
Yoshikazu Sugimoto Keio University
Saburo Sone
Saburo Sone University of Tokushima
Isamu Sugawara
Isamu Sugawara Saitama Medical University
Yukinari Kato
Yukinari Kato Tohoku University
Michael M. Gottesman
Michael M. Gottesman National Institutes of Health
Ira Pastan
Ira Pastan Center for Cancer Research
Shigeo Mori
Shigeo Mori University of Tokyo

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