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Molecular Biology
USA
2026

D-Index & Metrics

Molecular Biology

D-Index
137
Citations
82895
World Ranking
141
National Ranking
91

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award
  • 2018 - Member of the National Academy of Sciences
  • 2010 - Fellow of the American Academy of Arts and Sciences
  • 1988 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Michael M. Gottesman is affiliated with the National Institutes of Health in the United States. Their research focus spans multiple areas within Medicine and Biochemistry, Genetics and Molecular Biology, with a particular emphasis on Molecular Biology, Oncology, Cancer Research, Genetics, and Cell Biology.

The scientist's work frequently addresses topics such as Drug Transport and Resistance Mechanisms, Glioma Diagnosis and Treatment, MicroRNA in disease regulation, Epigenetics and DNA Methylation, Microtubule and mitosis dynamics, Histone Deacetylase Inhibitors Research, and RNA Interference and Gene Delivery.

Michael M. Gottesman has published extensively in well-known venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Cancer Drug Resistance
  • Journal of Biological Chemistry
  • Neuro-Oncology

The researcher has contributed to significant papers such as:

  • Carrier-Free, Amorphous Verteporfin Nanodrug for Enhanced Photodynamic Cancer Therapy and Brain Drug Delivery, 2024, Advanced Science
  • Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter, 2021, Scientific Reports
  • Reversing the direction of drug transport mediated by the human multidrug transporter P-glycoprotein, 2020, Proceedings of the National Academy of Sciences
  • A role for ceramide glycosylation in resistance to oxaliplatin in colorectal cancer, 2020, Experimental Cell Research
  • Multidrug transporters: recent insights from cryo-electron microscopy-derived atomic structures and animal models, 2020, F1000Research

Frequent co-authors in their research include:

  • Robert W. Robey
  • Suresh V. Ambudkar
  • William J.E. Frye
  • Donna Butcher
  • Joanna R. Thomas

Awards received by Michael M. Gottesman reflect recognition by the scientific community and include:

  • Member of the National Academy of Sciences, 2018
  • Fellow of the American Academy of Arts and Sciences, 2010
  • Fellow of the American Association for the Advancement of Science (AAAS), 1988

Best Publications

  • Biochemistry of multidrug resistance mediated by the multidrug transporter.

    Michael M. Gottesman;Ira Pastan

  • Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

    Franz Thiebaut;Takashi Tsuruo;Hirofumi Hamada;Michael M. Gottesman

  • Biochemical, cellular, and pharmacological aspects of the multidrug transporter

    Suresh V. Ambudkar;Saibal Dey;Christine A. Hrycyna;Muralidhara Ramachandra

  • Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

    Chang jie Chen;Janice E. Chin;Kazumitsu Ueda;Douglas P. Clark

  • Expression of a multidrug-resistance gene in human tumors and tissues

    A T Fojo;K Ueda;D J Slamon;D G Poplack

  • Expression of Multidrug Resistance Gene in Human Cancers

    Lori J. Goldstein;Hanan Galski;Antonio Fojo;Mark Willingham

  • Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine

    Kazumitsu Ueda;Carol Cardarelli;Michael M. Gottesman;Ira Pastan

  • P-glycoprotein: from genomics to mechanism

    Suresh V Ambudkar;Chava Kimchi-Sarfaty;Zuben E Sauna;Michael M Gottesman

  • The multidrug transporter, a double-edged sword.

    M. M. Gottesman;Ira Pastan

  • Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.

    Khew-Voon Chin;Kazumitsu Ueda;Ira Pastan;Michael M. Gottesman

  • Is the multidrug transporter a flippase

    Christopher F. Higgins;Michael M. Gottesman

  • Multiple-drug resistance in human cancer.

    I Pastan;M Gottesman

  • Cisplatin Resistance: A Cellular Self-Defense Mechanism Resulting from Multiple Epigenetic and Genetic Changes

    Ding-Wu Shen;Lynn M. Pouliot;Matthew D. Hall;Michael M. Gottesman

  • Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

    Igor B. Roninson;Janice E. Chin;Kyunghee Choi;Philippe Gros

  • Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.

    Franz Thiebaut;Takashi Tsuruo;Hirofumi Hamada;Michael M. Gottesman

  • Mechanisms of multidrug resistance in cancer.

    Jean-Pierre Gillet;Michael M. Gottesman

  • Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification.

    D.-W. Shen;A. Fojo;J. E. Chin;I. B. Roninson

  • Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.

    M M Cornwell;I Pastan;M M Gottesman

  • The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research.

    Michael M. Gottesman;Victor Ling

  • Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1.

    Brian P. Sorrentino;Stephen J. Brandt;David Bodine;Michael Gottesman

Frequent Co-Authors

Ira Pastan
Ira Pastan Center for Cancer Research
Suresh V. Ambudkar
Suresh V. Ambudkar National Institutes of Health
Matthew D. Hall
Matthew D. Hall National Institutes of Health
Xing-Jie Liang
Xing-Jie Liang National Center for Nanoscience and Technology, China
Mark C. Willingham
Mark C. Willingham Wake Forest University
Susan E. Bates
Susan E. Bates Columbia University
Takashi Tsuruo
Takashi Tsuruo Japanese Foundation For Cancer Research
Robert B. Innis
Robert B. Innis National Institutes of Health
Kazumitsu Ueda
Kazumitsu Ueda Kyoto University
Susan H. Garfield
Susan H. Garfield National Institutes of Health

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