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Chemistry

D-Index
44
Citations
9028
World Ranking
16696
National Ranking
370

Overview

Richard Callaghan is affiliated with the Australian National University in Australia. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a significant focus on the subfields of Oncology, Molecular Biology, Physiology, Organic Chemistry, and Nutrition and Dietetics.

The main topics covered in their work include Drug Transport and Resistance Mechanisms, Alzheimer's disease research and treatments, Glycosylation and Glycoproteins Research, Trace Elements in Health, Cholesterol and Lipid Metabolism, Genetics and Neurodevelopmental Disorders, and Cancer, Hypoxia, and Metabolism.

Frequent co-authors collaborating with Richard Callaghan include:

  • Ingrid C. Gelissen
  • Mary Board
  • Amanda B. Chai
  • Xuexin Gao
  • Alryel Yang

The most common publication venues for their articles are:

  • International Journal of Molecular Sciences
  • Biochimica et Biophysica Acta (BBA) - General Subjects
  • Cancer Drug Resistance
  • Polymers
  • ChemMedChem

Key recent papers authored or co-authored by Richard Callaghan include:

  • "Regulation of P-Glycoprotein in the Brain", 2022, International Journal of Molecular Sciences
  • "New Evidence for P-gp-Mediated Export of Amyloid-β Peptides in Molecular, Blood-Brain Barrier and Neuronal Models", 2020, International Journal of Molecular Sciences
  • "Characterisation of Hybrid Polymersome Vesicles Containing the Efflux Pumps NaAtm1 or P-Glycoprotein", 2020, Polymers
  • "1,3-Benzodioxole-Modified Noscapine Analogues: Synthesis, Antiproliferative Activity, and Tubulin-Bound Structure", 2021, ChemMedChem
  • "Mamma Mia, P-glycoprotein binds again", 2020, FEBS Letters

Best Publications

  • Communication between Multiple Drug Binding Sites on P-glycoprotein

    Catherine Martin;Georgina Berridge;Christopher F. Higgins;Prakash Mistry

  • Basis for design and development of platinum(IV) anticancer complexes.

    Matthew D Hall;Howard R Mellor;Richard Callaghan;Trevor W Hambley

  • Structure of the Multidrug Resistance P-glycoprotein to 2.5 nm Resolution Determined by Electron Microscopy and Image Analysis

    Mark F. Rosenberg;Richard Callaghan;Robert C. Ford;Christopher F. Higgins

  • Inhibition of the Multidrug Resistance P-Glycoprotein: Time for a Change of Strategy?

    Richard Callaghan;Frederick Luk;Mary Bebawy

  • Repacking of the transmembrane domains of P‐glycoprotein during the transport ATPase cycle

    Mark F. Rosenberg;Giles Velarde;Robert C. Ford;Catherine Martin

  • The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein

    Catherine Martin;Georgina Berridge;Prakash Mistry;Christopher Higgins

  • Modulation of multidrug resistance efflux pump activity to overcome chemoresistance in cancer.

    Szabolcs Modok;Howard R Mellor;Richard Callaghan

  • A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene

    HW van Veen;R Callaghan;L Soceneantu;A Sardini

  • Three-dimensional Structures of the Mammalian Multidrug Resistance P-glycoprotein Demonstrate Major Conformational Changes in the Transmembrane Domains upon Nucleotide Binding *

    Mark F. Rosenberg;Alhaji Bukar Kamis;Richard Callaghan;Christopher F. Higgins

  • Three-dimensional Structure of P-glycoprotein THE TRANSMEMBRANE REGIONS ADOPT AN ASYMMETRIC CONFIGURATION IN THE NUCLEOTIDE-BOUND STATE

    Mark F. Rosenberg;Richard Callaghan;Szabolcs Modok;Christopher F. Higgins

  • Resistance to chemotherapy in cancer: a complex and integrated cellular response.

    Howard R. Mellor;Richard Callaghan

  • Synthetic and natural opiates interact with P-glycoprotein in multidrug-resistant cells.

    Richard Callaghan;John R. Riordan

  • How can we best use structural information on P-glycoprotein to design inhibitors?

    Christopher A. McDevitt;Richard Callaghan

  • Structure of the multidrug resistance P-glycoprotein

    Christopher F. Higgins;Richard Callaghan;Kenneth J. Linton;Mark F. Rosenberg

  • Purification and 3D Structural Analysis of Oligomeric Human Multidrug Transporter ABCG2

    Christopher A. McDevitt;Richard F. Collins;Michael Conway;Szabolcs Modok

  • The importance of cholesterol in maintenance of P-glycoprotein activity and its membrane perturbing influence.

    Alice Rothnie;Daniel Theron;Loredana Soceneantu;Catherine Martin

  • P-glycoprotein: so many ways to turn it on.

    Richard Callaghan;Emily Crowley;M Biochem;Simon Potter

  • A model of quiescent tumour microregions for evaluating multicellular resistance to chemotherapeutic drugs

    H R Mellor;D J P Ferguson;R Callaghan

  • Drug binding sites on P-glycoprotein are altered by ATP binding prior to nucleotide hydrolysis.

    Catherine Martin;Georgina Berridge;Prakash Mistry;Christopher Higgins

  • Protein Kinase C-mediated Phosphorylation Does Not Regulate Drug Transport by the Human Multidrug Resistance P-glycoprotein

    Hugh R. Goodfellow;Alessandro Sardini;Stephan Ruetz;Richard Callaghan

  • Multiple drugbinding sites on the R482G isoform of the ABCG2 transporter

    R Clark;I D Kerr;R Callaghan

Frequent Co-Authors

Christopher F. Higgins
Christopher F. Higgins Hammersmith Hospital
Robert C. Ford
Robert C. Ford University of Manchester
Matthew D. Hall
Matthew D. Hall National Institutes of Health
Trevor W. Hambley
Trevor W. Hambley University of Sydney
Peter J. Scammells
Peter J. Scammells Monash University
Richard F. Collins
Richard F. Collins University of Manchester
D. Peter Tieleman
D. Peter Tieleman University of Calgary
Colin W. Pouton
Colin W. Pouton Monash University
Andrea Pellagatti
Andrea Pellagatti University of Oxford
David J. P. Ferguson
David J. P. Ferguson University of Oxford

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