Frances J. Sharom

Overview

Best Publications

• ABC multidrug transporters: structure, function and role in chemoresistance

  Frances J Sharom

  1192
  Citations

• ABC efflux pump-based resistance to chemotherapy drugs.

  Paul D. W. Eckford;Frances J. Sharom

  672
  Citations

• The P-glycoprotein efflux pump: how does it transport drugs?

  F.J. Sharom

  580
  Citations

• The P-glycoprotein multidrug transporter.

  Frances J. Sharom

  571
  Citations

• beta-Amyloid efflux mediated by p-glycoprotein.

  Fred C. Lam;Ronghua Liu;Peihua Lu;Adam B. Shapiro

  518
  Citations

• Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein.

  F.J. Sharom;X Yu;C.A. Doige

  306
  Citations

• The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter.

  Yolanda Romsicki;Frances J. Sharom

  299
  Citations

• Complex Interplay between the P-Glycoprotein Multidrug Efflux Pump and the Membrane: Its Role in Modulating Protein Function.

  Frances Jane Sharom

  295
  Citations

• A model for ganglioside behaviour in cell membranes

  Frances J. Sharom;Chris W.M. Grant

  276
  Citations

• CHARACTERIZATION OF THE ATPASE ACTIVITY OF P-GLYCOPROTEIN FROM MULTIDRUG-RESISTANT CHINESE HAMSTER OVARY CELLS

  F. J. Sharom;Xiaohong Yu;J. W. K. Chu;C. A. Doige

  265
  Citations

• Site-directed fluorescence labeling of P-glycoprotein on cysteine residues in the nucleotide binding domains.

  Ronghua Liu;Frances J. Sharom

  253
  Citations

• The effects of lipids and detergents on ATPase-active P-glycoprotein

  Carl A. Doige;Xiaohong Yu;Frances J. Sharom

  241
  Citations

• Phospholipid flippase activity of the reconstituted P-glycoprotein multidrug transporter

  Yolanda Romsicki;Frances J. Sharom

  215
  Citations

• ATPase activity of partially purified P-glycoprotein from multidrug-resistant Chinese hamster ovary cells.

  Carl A. Doige;Xiaohong Yu;Frances J. Sharom

  199
  Citations

• The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids

  Paul D. W. Eckford;Frances J. Sharom

  197
  Citations

• Multidrug Resistance and Chemosensitization: Therapeutic Implications for Cancer Chemotherapy

  Elias Georges;Frances J. Sharom;Victor Ling

  181
  Citations

• Intrinsic fluorescence of the P-glycoprotein multidrug transporter: sensitivity of tryptophan residues to binding of drugs and nucleotides

  Ronghua Liu;and Aleksander Siemiarczuk;Frances J. Sharom

  174
  Citations

• Glycosylphosphatidylinositol-anchored proteins: structure, function, and cleavage by phosphatidylinositol-specific phospholipase C.

  Frances J Sharom;Marty T Lehto

  172
  Citations

• Synthetic hydrophobic peptides are substrates for P-glycoprotein and stimulate drug transport.

  Frances J. Sharom;Xiaohong Yu;Giulio DiDIODATO;Joseph W. K. Chu

  162
  Citations

• Transport properties of P-glycoprotein in plasma membrane vesicles from multidrug-resistant Chinese hamster ovary cells

  Carl A. Doige;Frances J. Sharom

  160
  Citations