Linda Z. Penn

Research.com Recognitions

• 2023 - Research.com Biology and Biochemistry in Canada Leader Award

Overview

Best Publications

• Induction of apoptosis in fibroblasts by c-myc protein

  Gerard I. Evan;Andrew H. Wyllie;Christopher S. Gilbert;Trevor D. Littlewood

  3993
  Citations

• Reflecting on 25 years with MYC

  Natalie Meyer;Linda Z. Penn

  1830
  Citations

• HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis

  W W L Wong;J Dimitroulakos;M D Minden;M D Minden;L Z Penn;L Z Penn

  706
  Citations

• The myc oncogene: MarvelouslY Complex.

  Sara K Oster;Cynthia S W Ho;Erinn L Soucie;Linda Z Penn

  646
  Citations

• The interplay between cell signalling and the mevalonate pathway in cancer

  Peter J. Mullen;Rosemary Yu;Rosemary Yu;Joseph Longo;Joseph Longo;Michael C. Archer

  583
  Citations

• The c-Myc Oncogene Directly Induces the H19 Noncoding RNA by Allele-Specific Binding to Potentiate Tumorigenesis

  Dalia Barsyte-Lovejoy;Suzanne K. Lau;Paul C. Boutros;Fereshteh Khosravi

  566
  Citations

• The molecular role of Myc in growth and transformation: recent discoveries lead to new insights

  Linda M. Facchini;Linda Z. Penn

  521
  Citations

• Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

  Matthew G Annis;Erinn L Soucie;Paulina J Dlugosz;Jorge A Cruz-Aguado

  457
  Citations

• Dysregulation of the mevalonate pathway promotes transformation

  James W. Clendening;Aleks Pandyra;Paul C. Boutros;Samah El Ghamrasni

  436
  Citations

• Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types.

  W Zhu;A Cowie;G W Wasfy;L Z Penn

  428
  Citations

• MYC Deregulation in Primary Human Cancers

  Manpreet Kalkat;Manpreet Kalkat;Jason De Melo;Katherine Ashley Hickman;Katherine Ashley Hickman;Corey Lourenco;Corey Lourenco

  393
  Citations

• Negative autoregulation of c-myc transcription.

  L. J. Z. Penn;M. W. Brooks;E. M. Laufer;H. Land

  329
  Citations

• Three-Gene Prognostic Classifier for Early-Stage Non–Small-Cell Lung Cancer

  Suzanne K. Lau;Paul C. Boutros;Melania Pintilie;Fiona H. Blackhall

  320
  Citations

• Myc induces cyclin D1 expression in the absence of de novo protein synthesis and links mitogen-stimulated signal transduction to the cell cycle.

  J. I. Daksis;R. Y. Lu;L. M. Facchini;W. W. Marhin

  318
  Citations

• Rapamycin Enhances Apoptosis and Increases Sensitivity to Cisplatin in Vitro

  Yufang Shi;Andrea Frankel;Laszlo G. Radvanyi;Linda Z. Penn

  295
  Citations

• AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

  Shrivani Sriskanthadevan;Danny V. Jeyaraju;Timothy E. Chung;Swayam Prabha

  292
  Citations

• Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues

  Angela B Y Hui;Wei Shi;Paul C Boutros;Naomi Miller

  290
  Citations

• Blocking the Raf/MEK/ERK Pathway Sensitizes Acute Myelogenous Leukemia Cells to Lovastatin-Induced Apoptosis

  Jianghong Wu;W. Wei-Lynn Wong;W. Wei-Lynn Wong;Fereshteh Khosravi;Mark D. Minden

  275
  Citations

• Targeting tumor cell metabolism with statins.

  J W Clendening;L Z Penn

  272
  Citations

• Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: A potential therapeutic approach.

  Jim Dimitroulakos;Dana Nohynek;Dana Nohynek;Karen L. Backway;Karen L. Backway;David W. Hedley;David W. Hedley

  270
  Citations