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Dalia Barsyte-Lovejoy

Dalia Barsyte-Lovejoy

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
12939
World Ranking
16008
National Ranking
559

Overview

Dalia Barsyte-Lovejoy is affiliated with the Structural Genomics Consortium in Canada. Their research is primarily situated in the field of Biochemistry, Genetics, and Molecular Biology, with significant contributions to Molecular Biology, Oncology, Cell Biology, Immunology, and Hematology.

The scientific work of Barsyte-Lovejoy prominently addresses several key topics, including:

  • Cancer-related gene regulation
  • Protein degradation and inhibitors
  • Epigenetics and DNA methylation
  • Ubiquitin and proteasome pathways
  • Peptidase inhibition and analysis
  • Histone deacetylase inhibitors research
  • RNA modifications and cancer

Key recent publications exemplify the focus and scope of their research:

  • "Protein arginine methylation: from enigmatic functions to therapeutic targeting" (2021), published in Nature Reviews Drug Discovery
  • "PRMT5 inhibition disrupts splicing and stemness in glioblastoma" (2021), published in Nature Communications
  • "Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response" (2020), published in Nature Communications
  • "PRMT inhibition induces a viral mimicry response in triple-negative breast cancer" (2022), published in Nature Chemical Biology
  • "A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization" (2021), published in Nature Chemical Biology

Barsyte-Lovejoy has collaborated frequently with a core group of co-authors, collaborating most extensively with C.H. Arrowsmith, Magdalena M. Szewczyk, Masoud Vedadi, Peter J. Brown, and Fengling Li.

Their research has appeared repeatedly across a selection of notable scientific venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Journal of Medicinal Chemistry
  • Nature Chemical Biology
  • Zenodo (CERN European Organization for Nuclear Research)

Best Publications

  • Histone recognition and large-scale structural analysis of the human bromodomain family.

    Panagis Filippakopoulos;Sarah Picaud;Maria Mangos;Tracy Keates

  • A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

    Masoud Vedadi;Dalia Barsyte-Lovejoy;Feng Liu;Sylvie Rival-Gervier

  • The c-Myc Oncogene Directly Induces the H19 Noncoding RNA by Allele-Specific Binding to Potentiate Tumorigenesis

    Dalia Barsyte-Lovejoy;Suzanne K. Lau;Paul C. Boutros;Fereshteh Khosravi

  • Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

    Jiajun Zhu;Morgan A. Sammons;Greg Donahue;Zhixun Dou

  • An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1.

    Kyle D. Konze;Anqi Ma;Fengling Li;Dalia Barsyte-Lovejoy

  • Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation

    Scott B Rothbart;Krzysztof Krajewski;Nataliya Nady;Wolfram Tempel

  • Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

    Wenyu Yu;Emma J. Chory;Emma J. Chory;Amy K. Wernimont;Wolfram Tempel

  • Protein arginine methylation: from enigmatic functions to therapeutic targeting.

    Qin Wu;Matthieu Schapira;Cheryl H Arrowsmith;Cheryl H Arrowsmith;Cheryl H Arrowsmith;Dalia Barsyte-Lovejoy;Dalia Barsyte-Lovejoy

  • Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.

    Feng Liu;Dalia Barsyte-Lovejoy;Fengling Li;Yan Xiong

  • A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases

    Mohammad S. Eram;Yudao Shen;Magdalena M. Szewczyk;Hong Wu

  • Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression.

    Daniel Y.L. Mao;Daniel Y.L. Mao;John D. Watson;Pearlly S. Yan;Dalia Barsyte-Lovejoy;Dalia Barsyte-Lovejoy

  • Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.

    Jia Yi Fong;Jia Yi Fong;Luca Pignata;Luca Pignata;Pierre-Alexis Goy;Pierre-Alexis Goy;Kimihito Cojin Kawabata

  • Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

    Florian Grebien;Masoud Vedadi;Masoud Vedadi;Matthäus Getlik;Roberto Giambruno

  • Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors

    Jonathon Torchia;Brian Golbourn;Shengrui Feng;Shengrui Feng;King Ching Ho

  • Cancer therapeutics: targeting the dark side of Myc.

    Romina Ponzielli;Sigal Katz;Dalia Barsyte-Lovejoy;Linda Z. Penn

  • The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex

    Yupeng He;Sujatha Selvaraju;Michael L Curtin;Clarissa G Jakob

  • Integrin α11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells

    Chang-Qi Zhu;Svetlana N. Popova;Ewan R. S. Brown;Dalia Barsyte-Lovejoy

  • Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain

    Lindsey I. James;Dalia Barsyte-Lovejoy;Nan Zhong;Liubov Krichevsky

  • (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.

    Dalia Barsyte-Lovejoy;Fengling Li;Menno J. Oudhoff;John H. Tatlock

  • Control of the Hippo Pathway by Set7-Dependent Methylation of Yap

    Menno J. Oudhoff;Spencer A. Freeman;Amber L. Couzens;Frann Antignano

Frequent Co-Authors

Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium
Masoud Vedadi
Masoud Vedadi Structural Genomics Consortium
Matthieu Schapira
Matthieu Schapira University of Toronto
Peter Brown
Peter Brown University of Oxford
Jian Jin
Jian Jin Icahn School of Medicine at Mount Sinai
Mathieu Lupien
Mathieu Lupien Princess Margaret Cancer Centre
Linda Z. Penn
Linda Z. Penn University of Toronto
Stefan Knapp
Stefan Knapp Goethe University Frankfurt
Jinrong Min
Jinrong Min Structural Genomics Consortium
Anne-Claude Gingras
Anne-Claude Gingras Lunenfeld-Tanenbaum Research Institute

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