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Biology and Biochemistry
Germany
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
121
Citations
54427
World Ranking
606
National Ranking
40

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2025 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2023 - Research.com Biology and Biochemistry in Germany Leader Award

Overview

Stefan Knapp is a researcher primarily affiliated with Goethe University Frankfurt in Germany. Their scholarly work spans a diverse spectrum within biochemistry, genetics, and molecular biology, with a strong emphasis on molecular biology and oncology. The research portfolio also includes significant contributions to organic chemistry, cell biology, and cancer research.

The main topics of Stefan Knapp's research include:

  • Protein Degradation and Inhibitors
  • Ubiquitin and proteasome pathways
  • Protein Kinase Regulation and GTPase Signaling
  • Computational Drug Discovery Methods
  • Peptidase Inhibition and Analysis
  • Microtubule and mitosis dynamics
  • Cancer-related Molecular Pathways

Frequent coauthors collaborating with Knapp consist of:

  • Susanne Müller
  • A. Chaikuad
  • Andreas Krämer
  • Benedict-Tilman Berger
  • Sebastian Mathea

Their publications appear frequently in scientific venues, with notable numbers in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Medicinal Chemistry
  • European Journal of Medicinal Chemistry
  • Zenodo (CERN European Organization for Nuclear Research)
  • ACS Chemical Biology

Selected recent papers authored or coauthored by Stefan Knapp include:

  • Trends in kinase drug discovery: targets, indications and inhibitor design (2021, Nature Reviews Drug Discovery)
  • Structure of LRRK2 in Parkinson's disease and model for microtubule interaction (2020, Nature)
  • PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase (2020, Nature Chemical Biology)
  • Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy (2021, Oncogene)
  • Mapping the Endothelial Cell S -Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function (2020, Circulation)

Knapp's work is anchored in biomedical sciences, focusing primarily on the molecular mechanisms underlying protein function and modulation, which are critical to understanding diseases and therapeutic interventions. The research in kinase drug discovery and protein kinase regulation reflects an involvement in targeted molecular therapies.

Best Publications

  • Selective inhibition of BET bromodomains.

    Panagis Filippakopoulos;Jun Qi;Sarah Picaud;Yao Shen

  • Histone recognition and large-scale structural analysis of the human bromodomain family.

    Panagis Filippakopoulos;Sarah Picaud;Maria Mangos;Tracy Keates

  • Targeting bromodomains: epigenetic readers of lysine acetylation

    Panagis Filippakopoulos;Stefan Knapp

  • Protein production and purification.

    S Gräslund

  • The promise and peril of chemical probes.

    Cheryl H. Arrowsmith;James E. Audia;Christopher Austin;Jonathan Baell

  • Critical Residues for Structure and Catalysis in Short-chain Dehydrogenases/Reductases

    Charlotta Filling;Kurt D. Berndt;Kurt D. Berndt;Jordi Benach;Stefan Knapp

  • The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.

    K. L. Kavanagh;K. Guo;James Edward Dunford;James Edward Dunford;James Edward Dunford;X. Wu

  • Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome

    Alastair J. Barr;Emilie Ugochukwu;Wen Hwa Lee;Oliver N.F. King

  • Trends in kinase drug discovery: targets, indications and inhibitor design.

    Misty M. Attwood;Doriano Fabbro;Aleksandr V. Sokolov;Stefan Knapp;Stefan Knapp

  • Linear Motif Atlas for Phosphorylation-Dependent Signaling

    Martin Lee Miller;Martin Lee Miller;Lars Juhl Jensen;Francesca Diella;Claus Jørgensen

  • Bromodomains as therapeutic targets.

    Susanne Muller;Panagis Filippakopoulos;Stefan Knapp

  • Copper is required for oncogenic BRAF signalling and tumorigenesis

    Donita C. Brady;Matthew S. Crowe;Michelle L. Turski;G. Aaron Hobbs

  • RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain.

    Sarah Picaud;Christopher Wells;Ildiko Felletar;Deborah Brotherton

  • Small-molecule inhibition of BRDT for male contraception

    Martin M. Matzuk;Michael R. McKeown;Panagis Filippakopoulos;Qinglei Li

  • A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

    Oleg Fedorov;Brian Marsden;Vanda Pogacic;Peter Rellos

  • The bromodomain interaction module.

    Panagis Filippakopoulos;Stefan Knapp;Stefan Knapp

  • Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

    Kilian V. M. Huber;Eidarus Salah;Branka Radic;Manuela Gridling

  • Exploration of type II binding mode: A privileged approach for kinase inhibitor focused drug discovery?

    Zheng Zhao;Hong Wu;Hong Wu;Li Wang;Yi Liu

  • PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers

    Laurent Brault;Christelle Gasser;Franz Bracher;Kilian Huber

  • Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint

    Lucia Sironi;Marina Mapelli;Stefan Knapp;Anna De Antoni

Frequent Co-Authors

Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium
Aled M. Edwards
Aled M. Edwards Structural Genomics Consortium
Panagis Filippakopoulos
Panagis Filippakopoulos Structural Genomics Consortium
Oleg Fedorov
Oleg Fedorov University of Oxford
Susanne Müller
Susanne Müller Structural Genomics Consortium
Paul Brennan
Paul Brennan International Agency For Research On Cancer
Alex N. Bullock
Alex N. Bullock University of Oxford
Opher Gileadi
Opher Gileadi Karolinska Institute
Adrian Edwards
Adrian Edwards Cardiff University
Rudolf Ladenstein
Rudolf Ladenstein Karolinska Institute

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