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Benjamin E. Turk

Benjamin E. Turk

D-Index & Metrics

Molecular Biology

D-Index
57
Citations
17241
World Ranking
2132
National Ranking
1059

Overview

Benjamin E. Turk is affiliated with Yale University in the United States. Their research spans prominent fields such as Biochemistry, Genetics and Molecular Biology, with additional work in Medicine. Within these broad areas, their subfields of study include Molecular Biology, Cell Biology, Immunology, Oncology, and Computational Theory and Mathematics.

Their scientific contributions focus on several key topics, notably:

  • Melanoma and MAPK Pathways
  • Protein Kinase Regulation and GTPase Signaling
  • Computational Drug Discovery Methods
  • Ubiquitin and Proteasome Pathways
  • Cellular Mechanics and Interactions
  • Cancer Mechanisms and Therapy
  • Cellular Transport and Secretion

Benjamin E. Turk has published extensively, with notable recent papers including:

  • "An atlas of substrate specificities for the human serine/threonine kinome," 2023, Nature
  • "The intrinsic substrate specificity of the human tyrosine kinome," 2024, Nature
  • "TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin," 2021, Cancer Discovery
  • "PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK," 2021, Cell Reports
  • "Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting," 2020, Molecular Cell

Their work has been featured frequently in several publication venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Cancer Research
  • Science Signaling
  • The FASEB Journal

Frequent collaborators in their research include:

  • Hua Jane Lou
  • David Calderwood
  • Jaylissa Torres Robles
  • Titus J. Boggon
  • Lewis C. Cantley

Best Publications

  • AMPK phosphorylation of raptor mediates a metabolic checkpoint.

    Dana M. Gwinn;David B. Shackelford;Daniel F. Egan;Maria M. Mihaylova

  • Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

    Daniel F. Egan;Matthew G.H. Chun;Mitchell Vamos;Haixia Zou

  • Determination of protease cleavage site motifs using mixture-based oriented peptide libraries

    Benjamin E. Turk;Lisa L. Huang;Elizabeth T. Piro;Lewis C. Cantley

  • Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin

    Eric C. Griffith;Zhuang Su;Benjamin E. Turk;Shaoping Chen

  • Linear Motif Atlas for Phosphorylation-Dependent Signaling

    Martin Lee Miller;Martin Lee Miller;Lars Juhl Jensen;Francesca Diella;Claus Jørgensen

  • mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

    Seong A. Kang;Michael E. Pacold;Christopher L. Cervantes;Daniel Lim

  • A rapid method for determining protein kinase phosphorylation specificity.

    Jessica E Hutti;Emily T Jarrell;James D Chang;Derek W Abbott

  • Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs

    Janine Mok;Philip M. Kim;Philip M. Kim;Hugo Y.K. Lam;Stacy Piccirillo

  • Phosphorylation of Immunity-Related GTPases by a Toxoplasma gondii-Secreted Kinase Promotes Macrophage Survival and Virulence

    Sarah J. Fentress;Michael S. Behnke;Ildiko R. Dunay;Mona Mashayekhi

  • Early Steps in Autophagy Depend on Direct Phosphorylation of Atg9 by the Atg1 Kinase.

    Daniel Papinski;Martina Schuschnig;Wolfgang Reiter;Larissa Wilhelm

  • Structure and substrate specificity of the Pim-1 kinase.

    Alex N. Bullock;Judit Debreczeni;Ann L. Amos;Stefan Knapp

  • The Toxoplasma Pseudokinase ROP5 Forms Complexes with ROP18 and ROP17 Kinases that Synergize to Control Acute Virulence in Mice

    Ronald D. Etheridge;Aditi Alaganan;Keliang Tang;Hua Jane Lou

  • The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.

    Benjamin E Turk;Thiang Yian Wong;Robert Schwarzenbacher;Emily T Jarrell

  • Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation

    Panagis Filippakopoulos;Michael Kofler;Oliver Hantschel;Gerald D. Gish

  • The Arabidopsis ABA-activated kinase OST1 phosphorylates the bZIP transcription factor ABF3 and creates a 14-3-3 binding site involved in its turnover.

    Caroline Sirichandra;Marlène Davanture;Benjamin E. Turk;Michel Zivy

  • Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10.

    Cristina I. Caescu;Grace R. Jeschke;Benjamin E. Turk

  • Homing in: Mechanisms of Substrate Targeting by Protein Kinases

    Chad J. Miller;Benjamin E. Turk

  • IκB Kinase β Phosphorylates the K63 Deubiquitinase A20 To Cause Feedback Inhibition of the NF-κB Pathway

    Jessica E. Hutti;Benjamin E. Turk;John M. Asara;Averil Ma

  • A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms.

    Angela L. Williamson;Paolo X. Lecchi;Benjamin E. Turk;Youngchool Choe

  • Identification of small molecule inhibitors of anthrax lethal factor

    Rekha G Panchal;Ann R Hermone;Tam Luong Nguyen;Thiang Yian Wong

Frequent Co-Authors

Stefan Knapp
Stefan Knapp Goethe University Frankfurt
Lewis C. Cantley
Lewis C. Cantley Harvard University
Titus J. Boggon
Titus J. Boggon Yale University
Philip M. Kim
Philip M. Kim University of Toronto
David A. Calderwood
David A. Calderwood Yale University
Reuben J. Shaw
Reuben J. Shaw Salk Institute for Biological Studies
Vuk Stambolic
Vuk Stambolic University of Toronto
Jun O. Liu
Jun O. Liu Johns Hopkins University School of Medicine
Michael Snyder
Michael Snyder Stanford University

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