World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
88
Citations
27501
World Ranking
2707
National Ranking
1405

Research.com Recognitions

  • 2008 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2007 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Jun O. Liu is affiliated with the Johns Hopkins University School of Medicine in the United States. Their research contributions span multiple fields, primarily in biochemistry, genetics, and molecular biology, with significant work also in medicine. This multidisciplinary approach is reflected in their publication record and research topics.

Liu's recent papers illustrate a focus on complex biochemical and molecular processes related to disease mechanisms and therapeutic strategies. Notable publications include:

  • "Triptolide: reflections on two decades of research and prospects for the future" (2020) in Natural Product Reports
  • "PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson's disease" (2022) in Cell
  • "ATP-releasing SWELL1 channel in spinal microglia contributes to neuropathic pain" (2023) in Science Advances
  • "Targeting Neoantigens in Hepatocellular Carcinoma for Immunotherapy: A Futile Strategy?" (2020) in Hepatology
  • "An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor" (2023) in Science Translational Medicine

Their research covers a range of main study fields and subfields, including:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine
  • Molecular Biology
  • Immunology
  • Oncology
  • Cancer Research
  • Physiology

The scientist's key research topics include:

  • Histone Deacetylase Inhibitors Research
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Protein Kinase Regulation and GTPase Signaling
  • Signaling Pathways in Disease
  • Peptidase Inhibition and Analysis
  • Ubiquitin and Proteasome Pathways
  • Microbial Natural Products and Biosynthesis

Jun O. Liu has collaborated extensively with several frequent co-authors, such as:

  • Hanjing Peng
  • Daniel Romo
  • Zufeng Guo
  • Sarah A. Head
  • Qingli He

Their publications have appeared most often in select venues including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • SSRN Electronic Journal
  • The Cambridge Structural Database
  • Hepatology
  • ACS Chemical Biology

Jun O. Liu's career includes recognition by the American Association for the Advancement of Science, having been named a Fellow in both 2007 and 2008.

Best Publications

  • Genetic and pharmacological disruption of the TEAD–YAP complex suppresses the oncogenic activity of YAP

    Yi Liu-Chittenden;Bo Huang;Joong Sup Shim;Qian Chen

  • Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin

    Tilman Schneider-Poetsch;Jianhua Ju;Daniel E Eyler;Yongjun Dang

  • Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity.

    J. Liu;M. W. Albers;T. J. Wandless;S. Luan

  • Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth

    Huafeng Zhang;David Z. Qian;Yee Sun Tan;Kang Ae Lee

  • Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth

    James Kim;Jean Y. Tang;Jean Y. Tang;Ruoyu Gong;Jynho Kim

  • Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin

    Eric C. Griffith;Zhuang Su;Benjamin E. Turk;Shaoping Chen

  • Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

    Kang Ae Lee;Huafeng Zhang;David Z. Qian;Sergio Rey

  • XPB, a subunit of TFIIH, is a target of the natural product triptolide

    Denis V. Titov;Benjamin Gilman;Qing Li He;Shridhar Bhat

  • A three-hybrid system for detecting small ligand–protein receptor interactions

    Edward J. Licitra;Jun O. Liu

  • Recent advances in drug repositioning for the discovery of new anticancer drugs.

    Joong Sup Shim;Jun O. Liu

  • The HBV drug entecavir - effects on HIV-1 replication and resistance.

    Moira A. McMahon;Benjamin L. Jilek;Timothy P. Brennan;Lin Shen

  • Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells.

    Fan Pan;Hong Yu;Eric V. Dang;Joseph Barbi

  • Crystal structure of calcineurin–cyclophilin–cyclosporin shows common but distinct recognition of immunophilin–drug complexes

    Qing Huai;Hwa Young Kim;Yudong Liu;Yingdong Zhao;Yingdong Zhao

  • RNA-Binding Proteins HuR and PTB Promote the Translation of Hypoxia-Inducible Factor 1α

    Stefanie Galbán;Yuki Kuwano;Rudolf Pullmann;Jennifer L. Martindale

  • Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B.

    Hua He;Yongjun Dang;Fangyan Dai;Zekun Guo

  • Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2.

    Hong Duk Youn;Luo Sun;Ron Prywes;Jun O. Liu

  • Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells.

    Kang Ae Lee;David Z. Qian;Sergio Rey;Hong Wei

  • A clinical drug library screen identifies astemizole as an antimalarial agent

    Curtis R Chong;Xiaochun Chen;Lirong Shi;Jun O Liu

  • Cabin 1, A Negative Regulator for Calcineurin Signaling in T Lymphocytes

    Luo Sun;Hong Duk Youn;Christine Loh;Melissa Stolow

  • Cloning, expression, and purification of human cyclophilin in Escherichia coli and assessment of the catalytic role of cysteines by site-directed mutagenesis

    Jun Liu;Mark W. Albers;Chih-Ming Chen;Stuart L. Schreiber

Frequent Co-Authors

Daniel Romo
Daniel Romo Baylor University
Long Yu
Long Yu Fudan University
David J. Sullivan
David J. Sullivan Johns Hopkins University
Biao Yu
Biao Yu Chinese Academy of Sciences
Martin G. Pomper
Martin G. Pomper Johns Hopkins University School of Medicine
Brian W. Matthews
Brian W. Matthews University of Oregon
Dawei Ma
Dawei Ma Chinese Academy of Sciences
Robert F. Siliciano
Robert F. Siliciano Johns Hopkins University School of Medicine
Benjamin E. Turk
Benjamin E. Turk Yale University
Charles M. Rudin
Charles M. Rudin Memorial Sloan Kettering Cancer Center

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