World's Best Scientists 2026 revealed!
Titus J. Boggon

Titus J. Boggon

D-Index & Metrics

Biology and Biochemistry

D-Index
69
Citations
40759
World Ranking
7206
National Ranking
3304

Overview

Titus J. Boggon is affiliated with Yale University in the United States, specializing in research primarily within biochemistry, genetics, and molecular biology. Their work spans various interconnected subfields, including molecular biology, cell biology, neurology, genetics, and materials chemistry.

Their research topics cover a wide range of areas such as protein kinase regulation and GTPase signaling, enzyme structure and function, cellular transport and secretion, vascular malformations diagnosis and treatment, intracranial aneurysms treatment and complications, protein structure and dynamics, and cellular mechanics and interactions.

Frequent publication venues for their research include:

  • Journal of Biological Chemistry
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cellular and Molecular Life Sciences
  • Molecular Cell

Their recent papers demonstrate a focus on molecular mechanisms and disease-related processes. Notable recent publications include:

  • Integrated genomic analyses of cutaneous T-cell lymphomas reveal the molecular bases for disease heterogeneity (2021, Blood)
  • Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients (2021, The Journal of Experimental Medicine)
  • Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1 (2021, Nature Communications)
  • SH2 Domain Binding: Diverse FLVRs of Partnership (2020, Frontiers in Endocrinology)
  • The pseudoGTPase group of pseudoenzymes (2020, FEBS Journal)

Titus J. Boggon collaborates frequently with a group of coauthors whose repeated partnerships suggest closely linked research activities. Frequent collaborators include:

  • Lila M. Gierasch
  • F. Peter Guengerich
  • Ruma Banerjee
  • Roger Colbran
  • Peter Cresswell

The broad spectrum of their research integrates molecular and cellular mechanisms relevant to protein function and regulation, with particular attention to enzyme and protein kinase activity. Their work also interfaces with clinical topics related to vascular conditions and cellular dynamics, reflecting a multidisciplinary approach spanning fundamental biology to disease contexts.

Best Publications

  • EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.

    J. Guillermo Paez;Pasi A. Jänne;Pasi A. Jänne;Jeffrey C. Lee;Sean Tracy

  • EGFR Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib

    Susumu Kobayashi;Titus J. Boggon;Tajhal Dayaram;Pasi A. Jänne

  • Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.

    Ross L. Levine;Ross L. Levine;Martha Wadleigh;Jan Cools;Benjamin L. Ebert;Benjamin L. Ebert

  • Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.

    Michael Krauthammer;Yong Lin Kong;Byung Hak Ha;Perry Evans

  • Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

    Zhenfeng Zhang;Zhenfeng Zhang;Jae Cheol Lee;Luping Lin;Victor Olivas

  • Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity

    Cai-Hong Yun;Titus J. Boggon;Yiqun Li;Michele S. Woo

  • Structure and regulation of Src family kinases.

    Titus J Boggon;Michael J Eck

  • Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

    Taro Hitosugi;Sumin Kang;Matthew G. Vander Heiden;Tae Wook Chung

  • C-cadherin ectodomain structure and implications for cell adhesion mechanisms

    Titus J. Boggon;John Murray;Sophie Chappuis-Flament;Ellen Wong

  • BIM Mediates EGFR Tyrosine Kinase Inhibitor-Induced Apoptosis in Lung Cancers with Oncogenic EGFR Mutations

    Daniel Botelho Costa;Balázs Halmos;Amit Kumar;Susan T Schumer

  • Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation

    Neil Romberg;Khatoun Al Moussawi;Carol Nelson-Williams;Amy L Stiegler

  • G-Protein Signaling Through Tubby Proteins

    Sandro Santagata;Titus J. Boggon;Cheryl L. Baird;Carlos A. Gomez

  • Genomic landscape of cutaneous T cell lymphoma

    Jaehyuk Choi;Gerald Goh;Trent Walradt;Bok S Hong

  • Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.

    Taro Hitosugi;Lu Zhou;Shannon Elf;Jun Fan

  • Structure and clinical relevance of the epidermal growth factor receptor in human cancer

    Amit Kumar;Edward T. Petri;Balazs Halmos;Titus J. Boggon

  • Activating alleles of JAK3 in acute megakaryoblastic leukemia

    Denise K. Walters;Denise K. Walters;Thomas Mercher;Ting Lei Gu;Thomas O'Hare;Thomas O'Hare

  • Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism

    Taro Hitosugi;Jun Fan;Tae Wook Chung;Katherine Lythgoe

  • Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth

    Lingtao Jin;Dan Li;Gina N. Alesi;Jun Fan

  • Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma.

    Siming Zhao;Murim Choi;John D. Overton;Stefania Bellone

  • Tyr Phosphorylation of PDP1 Toggles Recruitment between ACAT1 and SIRT3 to Regulate the Pyruvate Dehydrogenase Complex

    Jun Fan;Changliang Shan;Hee-Bum Kang;Shannon Elf

Frequent Co-Authors

Fadlo R. Khuri
Fadlo R. Khuri American University of Beirut
David A. Calderwood
David A. Calderwood Yale University
Sagar Lonial
Sagar Lonial Emory University
Michael J. Eck
Michael J. Eck Harvard University
Joseph Schlessinger
Joseph Schlessinger Yale University
Richard P. Lifton
Richard P. Lifton Rockefeller University
Chuan He
Chuan He University of Chicago
Dong M. Shin
Dong M. Shin Emory University
D. Gary Gilliland
D. Gary Gilliland Fred Hutchinson Cancer Research Center
Matthew Meyerson
Matthew Meyerson Harvard University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring studies in Biology and Biochemistry opens a range of promising online academic options and career directions in health and science fields. Many students looking for practical, patient-focused roles consider programs such as the top dietetics masters programs, which prepare graduates for rewarding work in nutrition and wellness.

For those eager to enter the workforce quickly, there are flexible pathways. Accessible medical assistant classes online with financial aid make it easier to start a healthcare career without high upfront costs. If you’re already a certified medical assistant (CMA), pursuing specialized cma to lpn programs online can boost your credentials and job opportunities in nursing.

Many schools now offer flexible, online biology bachelor's degree options, allowing you to complete your studies at your own pace. These programs provide a strong scientific foundation for roles in research, healthcare, education, and beyond. Whether your goal is patient care, lab research, or teaching, the right online pathway can help you build the career you want in biology and biochemistry.

Best Scientists Citing Titus J. Boggon

Trending Scientists

Recently Published Articles