2026 David A. Calderwood: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	60	11731	10802	5046	4520	126	19281

Overview

David A. Calderwood is affiliated with Yale University in the United States. The research work centers on biochemistry, genetics, and molecular biology with an emphasis on molecular and cell biology, immunology, and biomedical engineering.

The scientist's research spans several main topics including:

Cell Adhesion Molecules Research
Cellular Mechanics and Interactions
Immunotherapy and Immune Responses
3D Printing in Biomedical Research
Melanoma and MAPK Pathways
Protein Tyrosine Phosphatases
Ubiquitin and proteasome pathways

Recent papers authored or coauthored by David A. Calderwood include:

Organization, dynamics and mechanoregulation of integrin-mediated cell-ECM adhesions, 2022, Nature Reviews Molecular Cell Biology
Chapter 22: Structural and signaling functions of integrins, 2020, Biochimica et Biophysica Acta (BBA) - Biomembranes
Intracellular tension sensor reveals mechanical anisotropy of the actin cytoskeleton, 2023, Nature Communications
Signalling through cerebral cavernous malformation protein networks, 2020, Open Biology
PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK, 2021, Cell Reports

The frequent coauthors who collaborate with this scientist are:

Benjamin E. Turk
Hua Jane Lou
Clotilde Huet-Calderwood
Leena Kuruvilla

Publications appear predominantly in venues such as:

bioRxiv (Cold Spring Harbor Laboratory)
Nature Communications
Journal of Biological Chemistry
Communications Biology
Nature Reviews Molecular Cell Biology

The scientist's body of work contributes extensively to fields of molecular biology and cell biology as well as immunology and allergy, also interfacing with biomedical engineering domains.

Best Publications

Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

Seiji Tadokoro;Sanford J. Shattil;Koji Eto;Vera Tai

1472
Citations
Integrin signalling at a glance

David S. Harburger;David A. Calderwood

1189
Citations
The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation.

D. A. Calderwood;R. Zent;R. Grant;D. J. G. Rees

892
Citations
Integrin cytoplasmic domain-binding proteins.

S. Liu;D.A. Calderwood;M.H. Ginsberg

837
Citations
Forces and Bond Dynamics in Cell Adhesion

Evan A. Evans;David A. Calderwood

698
Citations
Integrins and actin filaments: reciprocal regulation of cell adhesion and signaling.

David A. Calderwood;Sanford J. Shattil;Mark H. Ginsberg

670
Citations
Talins and kindlins: partners in integrin-mediated adhesion

David A. Calderwood;Iain D. Campbell;David R. Critchley

648
Citations
Structural determinants of integrin recognition by talin

Begoña Garcı́a-Alvarez;José M de Pereda;David A Calderwood;Tobias S Ulmer

602
Citations
Reconstructing and Deconstructing Agonist-Induced Activation of Integrin αIIbβ3

Jaewon Han;Chinten James Lim;Naohide Watanabe;Alessandra Soriani

545
Citations
The phosphotyrosine binding-like domain of talin activates integrins.

David A. Calderwood;Boxu Yan;Jose M. de Pereda;Begoña Garcı́a Alvarez

535
Citations
Integrin β cytoplasmic domain interactions with phosphotyrosine-binding domains: A structural prototype for diversity in integrin signaling

David A. Calderwood;Yosuke Fujioka;Jose M. de Pereda;Begoña García-Alvarez

527
Citations
The Molecular Basis of Filamin Binding to Integrins and Competition with Talin.

Tiila Kiema;Yatish Lad;Pengju Jiang;Camilla L. Oxley

494
Citations
PEA-15 Mediates Cytoplasmic Sequestration of ERK MAP Kinase

Etienne Formstecher;Joe W. Ramos;Mireille Fauquet;David A. Calderwood

377
Citations
Kindlin-1 and -2 Directly Bind the C-terminal Region of β Integrin Cytoplasmic Tails and Exert Integrin-specific Activation Effects

David S. Harburger;Mohamed Bouaouina;David A. Calderwood

358
Citations
Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration.

David A. Calderwood;Anna Huttenlocher;William B. Kiosses;David M. R Rose

342
Citations
Calpain Cleavage Promotes Talin Binding to the β3Integrin Cytoplasmic Domain

Boxu Yan;David A. Calderwood;Brian Yaspan;Mark H. Ginsberg

313
Citations
Filamins in Mechanosensing and Signaling

Ziba Razinia;Toni Mäkelä;Jari Ylänne;David A Calderwood

304
Citations
FAK promotes recruitment of talin to nascent adhesions to control cell motility.

Christine Lawson;Ssang-Taek Lim;Sean Uryu;Xiao Lei Chen

266
Citations
FAK promotes recruitment of talin to nascent adhesions to control cell motilityFAK brings talin to nascent adhesions

Christine Lawson;Ssang-Taek Lim;Sean Uryu;Xiao Lei Chen

253
Citations
Integrin alpha 2 I-domain is a binding site for collagens

D Tuckwell;D A Calderwood;L J Green;M J Humphries

244
Citations