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Biology and Biochemistry

D-Index
92
Citations
26756
World Ranking
2240
National Ranking
148

Overview

David R. Critchley is affiliated with the University of Leicester in the United Kingdom. Their primary research spans the fields of biochemistry, genetics, molecular biology, and medicine, with a strong focus on cell biology and immunology and allergy as subfields of study.

Their work centers on cellular mechanics and interactions, particularly investigating cell adhesion molecules and the Hippo pathway signaling involving YAP/TAZ. These topics form the foundation of their research contributions.

Recent publications by this scientist include:

  • Tensin3 interaction with talin drives the formation of fibronectin-associated fibrillar adhesions, 2022, The Journal of Cell Biology
  • Tensin3 interaction with talin drives formation of fibronectin-associated fibrillar adhesions, 2021, bioRxiv (Cold Spring Harbor Laboratory)

Frequent coauthors who have collaborated in multiple publications with David R. Critchley are:

  • Paul Atherton
  • Rafaella Konstantinou
  • Suat Peng Neo
  • Emily Wang
  • Eleonora Balloi

The venues where this researcher has commonly published include:

  • The Journal of Cell Biology
  • bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • Rapid leukocyte migration by integrin-independent flowing and squeezing

    Tim Lämmermann;Bernhard L. Bader;Susan J. Monkley;Tim Worbs

  • Focal adhesions - the cytoskeletal connection.

    David R Critchley

  • Calpain-mediated proteolysis of talin regulates adhesion dynamics

    Santos J. Franco;Mary A. Rodgers;Benjamin J. Perrin;Jaewon Han

  • Talins and kindlins: partners in integrin-mediated adhesion

    David A. Calderwood;Iain D. Campbell;David R. Critchley

  • The structure and regulation of vinculin.

    Wolfgang H. Ziegler;Robert C. Liddington;David R. Critchley

  • Structural determinants of integrin recognition by talin

    Begoña Garcı́a-Alvarez;José M de Pereda;David A Calderwood;Tobias S Ulmer

  • The structure and function of α-actinin

    Andrew Blanchard;Vasken Ohanian;David Critchley

  • Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin

    Guoying Jiang;Grégory Giannone;David R. Critchley;Emiko Fukumoto

  • Talin depletion reveals independence of initial cell spreading from integrin activation and traction

    Xian Zhang;Guoying Jiang;Yunfei Cai;Susan J. Monkley

  • Endocrine functions of bone in mineral metabolism regulation

    L. Darryl Quarles

  • Structural basis for vinculin activation at sites of cell adhesion

    Constantina Bakolitsa;Daniel M. Cohen;Laurie A. Bankston;Andrey A. Bobkov

  • The structure of an integrin/talin complex reveals the basis of inside‐out signal transduction

    Nicholas J Anthis;Kate L Wegener;Feng Ye;Chungho Kim

  • Biochemical and Structural Properties of the Integrin-Associated Cytoskeletal Protein Talin

    David R. Critchley

  • Talin is required for integrin-mediated platelet function in hemostasis and thrombosis

    Brian G. Petrich;Patrizia Marchese;Zaverio M. Ruggeri;Saskia Spiess

  • Talin1 is critical for force-dependent reinforcement of initial integrin–cytoskeleton bonds but not tyrosine kinase activation

    Grégory Giannone;Guoying Jiang;Deborah H. Sutton;David R. Critchley

  • Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site

    L. Hemmings;D. J. G. Rees;V. Ohanian;S. J. Bolton

  • Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo

    Bernhard Nieswandt;Markus Moser;Irina Pleines;David Varga-Szabo

  • Talin at a glance.

    David R. Critchley;Alexandre R. Gingras

  • Disruption of the talin gene arrests mouse development at the gastrulation stage

    Susan J. Monkley;Xiao-Hong Zhou;Sarah J. Kinston;Susan M. Giblett

  • Utrophin actin binding domain: analysis of actin binding and cellular targeting

    S.J. Winder;L. Hemmings;S.K. Maciver;S.J. Bolton

Frequent Co-Authors

Gordon C. K. Roberts
Gordon C. K. Roberts University of Leicester
Mark H. Ginsberg
Mark H. Ginsberg University of California, San Diego
Iain D. Campbell
Iain D. Campbell University of Oxford
Simon T. Barry
Simon T. Barry AstraZeneca (United Kingdom)
Robert C. Liddington
Robert C. Liddington Discovery Institute
David A. Calderwood
David A. Calderwood Yale University
Reinhard Fässler
Reinhard Fässler Max Planck Society
Roy Zent
Roy Zent Vanderbilt University Medical Center
Charles H. Streuli
Charles H. Streuli University of Manchester
Jim C. Norman
Jim C. Norman University of Glasgow

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