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Biology and Biochemistry

D-Index
71
Citations
17207
World Ranking
6682
National Ranking
506

Overview

Charles H. Streuli is affiliated with the University of Manchester in the United Kingdom. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine, with a particular focus on subfields such as Molecular Biology, Oncology, Cell Biology, Biophysics, and Immunology and Allergy.

Their work extensively covers topics related to cancer biology and cellular mechanisms, including:

  • Cancer Cells and Metastasis
  • Cancer-related Molecular Pathways
  • Cancer-related gene regulation
  • Ubiquitin and proteasome pathways
  • Genomics and Chromatin Dynamics
  • Wnt/β-catenin signaling in development and cancer
  • Cellular Mechanics and Interactions

Recent publications by Charles H. Streuli highlight research on breast cancer and cellular mechanics in the tumor microenvironment. Key papers include:

  • Elevated EDAR signalling promotes mammary gland tumourigenesis with squamous metaplasia, 2021, Oncogene
  • RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells, 2023, Oncogene
  • Increased microenvironment stiffness leads to altered aldehyde metabolism and DNA damage in mammary epithelial cells through a RhoA-dependent mechanism, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Integrin-Mediated Survival Signals Regulate the Apoptotic Function of Bax through Its Conformation and Subcellular Localization, 2020, UNC Libraries
  • Matrix stiffness drives alterations in aldehyde metabolism, inducing DNA damage and transformation, 2025, Scientific Reports

The venues in which Charles H. Streuli frequently publishes include:

  • Oncogene
  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries
  • Scientific Reports

Collaboration is a significant aspect of their work, with frequent coauthors including Andrew Gilmore, Keith Brennan, Andrew H. Sims, Amber Wood, and Heyuan Sun. These partnerships have contributed to multiple research outputs and reflect an interdisciplinary approach to the study of cancer biology and cellular processes.

Best Publications

  • Vinculin controls focal adhesion formation by direct interactions with talin and actin

    Jonathan D. Humphries;Pengbo Wang;Charles H Streuli;Benny Geiger

  • Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity.

    Charles H. Streuli;Nina Bailey;Mina J. Bissell

  • EXTRACELLULAR MATRIX REMODELLING AND CELLULAR DIFFERENTIATION

    Charles Streuli

  • Laminin mediates tissue-specific gene expression in mammary epithelia

    Charles H. Streuli;Christian Schmidhauser;Nina Bailey;Peter Yurchenco

  • Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

    Suzanne A. Eccles;Eric O. Aboagye;Simak Ali;Annie S. Anderson

  • Expression of extracellular matrix components is regulated by substratum

    Charles H. Streuli;Mina J. Bissell

  • Signal co-operation between integrins and other receptor systems

    Charles H. Streuli;Nasreen Akhtar

  • Extracellular matrix regulates expression of the TGF-beta 1 gene.

    C H Streuli;C Schmidhauser;M Kobrin;M J Bissell

  • Integrin-Mediated Survival Signals Regulate the Apoptotic Function of Bax through Its Conformation and Subcellular Localization

    Andrew P. Gilmore;Anthony D. Metcalfe;Lewis H. Romer;Charles H. Streuli

  • Requirement of basement membrane for the suppression of programmed cell death in mammary epithelium

    Shirley Pullan;James Wilson;Anthony Metcalfe;Gwynneth M. Edwards

  • Desmosomal adhesion regulates epithelial morphogenesis and cell positioning

    Sarah K. Runswick;Mike J. O'Hare;Louise Jones;Charles H. Streuli

  • Signalling pathways linking integrins with cell cycle progression.

    Paulina Moreno-Layseca;Charles H. Streuli

  • Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor.

    Andrew P. Gilmore;Anthony J. Valentijn;Pengbo Wang;Ann M. Ranger

  • Neural precursor cell chain migration and division are regulated through different beta1 integrins

    T S Jacques;J B Relvas;S Nishimura;R Pytela

  • Integrins and cell-fate determination.

    Charles H. Streuli

  • Extracellular matrix regulates apoptosis in mammary epithelium through a control on insulin signaling.

    Nadia Farrelly;Yi Ju Lee;Janine Oliver;Caroline Dive

  • Control of Integrin Expression by Extracellular Matrix

    Marc Delcommenne;Charles H. Streuli

  • Ablation of β1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation

    Matthew J. Naylor;Na Li;Julia Cheung;Emma T. Lowe

  • A Role in Migration for the αvβ1 Integrin Expressed on Oligodendrocyte Precursors

    Richard Milner;Gwynneth Edwards;Charles Streuli;Charles ffrench-Constant;Charles ffrench-Constant

  • Bax Exists in a Dynamic Equilibrium between the Cytosol and Mitochondria to Control Apoptotic Priming

    Barbara Schellenberg;Pengbo Wang;James A. Keeble;Ricardo Rodriguez-Enriquez

Frequent Co-Authors

Mina J. Bissell
Mina J. Bissell Lawrence Berkeley National Laboratory
John A. Hickman
John A. Hickman University of Manchester
Beverly E. Griffin
Beverly E. Griffin Imperial College London
Neil A. Hanley
Neil A. Hanley University of Manchester
Charles ffrench-Constant
Charles ffrench-Constant University of Edinburgh
David R. Critchley
David R. Critchley University of Leicester
Caroline Dive
Caroline Dive University of Manchester
Richard Milner
Richard Milner San Diego Biomedical Research Institute
Martin J. Humphries
Martin J. Humphries University of Manchester
Paul Fernyhough
Paul Fernyhough University of Manitoba

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