John A. Hickman

Overview

Best Publications

• Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

  F. Oberhammer;J.W. Wilson;C. Dive;I.D. Morris

  1470
  Citations

• Functional and physical interaction between Bcl‐XL and a BH3‐like domain in Beclin‐1

  M Chiara Maiuri;Gaëtane Le Toumelin;Alfredo Criollo;Alfredo Criollo;Alfredo Criollo;Jean-Christophe Rain

  1350
  Citations

• Apoptosis induced by anticancer drugs.

  John A. Hickman

  1277
  Citations

• The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

  András Kotschy;Zoltán Szlavik;James Murray;James Davidson

  1004
  Citations

• The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice.

  Anita J. Merritt;Christopher S. Potten;Christopher J. Kemp;John A. Hickman

  768
  Citations

• Cell Damage-induced Conformational Changes of the Pro-Apoptotic Protein Bak In Vivo Precede the Onset of Apoptosis

  Gareth J. Griffiths;Laurence Dubrez;Clive P. Morgan;Neil A. Jones

  632
  Citations

• Drug-target interactions: only the first step in the commitment to a programmed cell death?

  C. Dive;J. A. Hickman

  591
  Citations

• BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L).

  Maria Chiara Maiuri;Alfredo Criollo;Ezgi Tasdemir;Jose Miguel Vicencio

  528
  Citations

• Antitumor Activity and Pharmacokinetics in Mice of 8-Carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a Novel Drug with Potential as an Alternative to Dacarbazine

  Malcolm F. G. Stevens;John A. Hickman;Simon P. Langdon;David Chubb

  437
  Citations

• Limits to Personalized Cancer Medicine

  Ian F. Tannock;John A. Hickman

  428
  Citations

• Three-dimensional models of cancer for pharmacology and cancer cell biology: capturing tumor complexity in vitro/ex vivo

  John A. Hickman;Ralph Graeser;Ronald de Hoogt;Suzana Vidic

  394
  Citations

• Differential expression of bcl-2 in intestinal epithelia. Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia.

  Anita J Merritt;Christopher S Potten;A J Watson;D Y Loh

  379
  Citations

• Requirement of basement membrane for the suppression of programmed cell death in mammary epithelium

  Shirley Pullan;James Wilson;Anthony Metcalfe;Gwynneth M. Edwards

  363
  Citations

• Hypersensitivity of Human Testicular Tumors to Etoposide-induced Apoptosis Is Associated with Functional p53 and a High Bax:Bcl-2 Ratio

  Christine M. Chresta;John R. W. Masters;John A. Hickman

  363
  Citations

• bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways.

  T C Fisher;A E Milner;C D Gregory;A L Jackman

  339
  Citations

• Apoptosis and cancer chemotherapy.

  Guy Makin;John A. Hickman

  298
  Citations

• Apoptosis in small intestinal epithelial from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after gamma-irradiation.

  Anita J Merritt;Terence D Allen;Christopher S Potten;John A Hickman

  287
  Citations

• Characterization of radiation-induced apoptosis in the small intestine and its biological implications

  Christopher S Potten;A Merritt;John A Hickman;P Hall

  284
  Citations

• Apoptosis and cancer chemotherapy

  John A Hickman;Christopher S Potten;A J Merritt;T C Fisher

  157
  Citations

• Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia

  Anita J. Merritt;Christopher S. Potten;Alastair J. M. Watson;Dennis Y. Loh

  95
  Citations