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D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
11007
World Ranking
13281
National Ranking
1037

Overview

Simon P. Langdon is affiliated with the University of Edinburgh in the United Kingdom and contributes to scientific research primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work spans molecular biology, oncology, genetics, pulmonary and respiratory medicine, and cancer research, with a notable focus on topics related to hormone effects, DNA repair, and cancer therapies.

The scientist's research topics include:

  • Estrogen and related hormone effects
  • DNA Repair Mechanisms
  • Ovarian cancer diagnosis and treatment
  • PARP inhibition in cancer therapy
  • Advanced Breast Cancer Therapies
  • Cancer-related Molecular Pathways
  • ATP Synthase and ATPases Research

Simon P. Langdon has published several notable papers, including:

  • Estrogen Signaling and Its Potential as a Target for Therapy in Ovarian Cancer, 2020, Cancers
  • Estrogen Receptor Signaling in Cancer, 2020, Cancers

Other frequently cited papers from their recent corpus, though not authored by Langdon, appear alongside their work and reflect the broader research environment they are part of:

  • The impact of tumour pH on cancer progression: strategies for clinical intervention, 2020, Exploration of Targeted Anti-tumor Therapy
  • Precision Medicine and the Role of Biomarkers of Radiotherapy Response in Breast Cancer, 2020, Frontiers in Oncology
  • Evaluation of Gene Expression Data From Cybrids and Tumours Highlights Elevated NDRG1-Driven Proliferation in Triple-Negative Breast Cancer, 2020, Breast Cancer Basic and Clinical Research

Frequent co-authors collaborating with Simon P. Langdon include:

  • James Meehan
  • Mark Gray
  • David J. Argyle
  • Ian Kunkler
  • C. Simon Herrington

Langdon's work is commonly published in the following venues:

  • Exploration of Targeted Anti-tumor Therapy
  • Cancers
  • Frontiers in Oncology
  • Breast Cancer Basic and Clinical Research
  • Cellular Signalling

The scientist's research contributions center on molecular pathways and mechanisms underlying cancer progression and treatment, with particular emphasis on estrogen signaling pathways in ovarian and breast cancers and the molecular underpinnings related to DNA repair and targeted therapy.

Best Publications

  • Relationship between differentially expressed mRNA and mRNA-protein correlations in a xenograft model system

    Antonis Koussounadis;Simon Langdon;In Hwa Um;David James Harrison

  • Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

    Suzanne A. Eccles;Eric O. Aboagye;Simak Ali;Annie S. Anderson

  • Antitumor Activity and Pharmacokinetics in Mice of 8-Carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a Novel Drug with Potential as an Alternative to Dacarbazine

    Malcolm F. G. Stevens;John A. Hickman;Simon P. Langdon;David Chubb

  • Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma.

    Wataru Sakai;Elizabeth M. Swisher;Céline Jacquemont;Kurapaty Venkatapoorna Chandramohan

  • Characterization and properties of nine human ovarian adenocarcinoma cell lines.

    Simon P. Langdon;Sandra S. Lawrie;Frances G. Hay;Mary M. Hawkes

  • The prognostic value of epidermal growth factor receptor mRNA expression in primary ovarian cancer.

    J. M. S. Bartlett;S. P. Langdon;B. J. B. Simpson;M. Stewart

  • Quantitative analysis of changes in ER, PR and HER2 expression in primary breast cancer and paired nodal metastases

    S.J. Aitken;J.S. Thomas;S.P. Langdon;D.J. Harrison

  • Antiestrogen Therapy Is Active in Selected Ovarian Cancer Cases: The Use of Letrozole in Estrogen Receptor–Positive Patients

    John F. Smyth;Charlie Gourley;Graeme Walker;Melanie J. MacKean

  • New strategies for targeting the hypoxic tumour microenvironment in breast cancer.

    Carol Ward;Simon P. Langdon;Peter Mullen;Adrian L. Harris

  • Estrogen receptor-α mediates gene expression changes and growth response in ovarian cancer cells exposed to estrogen

    Amanda J M O’Donnell;Kenneth G Macleod;David J Burns;John F Smyth

  • CA125 Response Is Associated with Estrogen Receptor Expression in a Phase II Trial of Letrozole in Ovarian Cancer: Identification of an Endocrine-sensitive Subgroup

    Angela Bowman;Hani Gabra;Simon P Langdon;Alastair Lessells

  • Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinoma

    Susanna L Cooke;Charlotte Ky Ng;Nataliya Melnyk;Maria J Garcia

  • Systems biology reveals new strategies for personalizing cancer medicine and confirms the role of PTEN in resistance to trastuzumab.

    Dana Faratian;Alexey Goltsov;Galina Lebedeva;Anatoly Sorokin

  • Growth of small cell lung cancer cells: stimulation by multiple neuropeptides and inhibition by broad spectrum antagonists in vitro and in vivo.

    Tariq Sethi;Simon Langdon;John Smyth;Enrique Rozengurt

  • Altered ErbB Receptor Signaling and Gene Expression in Cisplatin-Resistant Ovarian Cancer

    Kenneth Macleod;Peter Mullen;Jane Sewell;Genevieve Rabiasz

  • Expression of the heat shock protein HSP27 in human ovarian cancer.

    S. P. Langdon;G. J. Rabiasz;G. L. Hirst;R. J. B. King

  • A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models

    Chrysi Xintaropoulou;Carol Ward;Alan Wise;Hugh Marston

  • Implantable biosensors and their contribution to the future of precision medicine.

    M Gray;J Meehan;C Ward;Simon P Langdon

  • High antitumour activity of ET743 against human tumour xenografts from melanoma, non-small-cell lung and ovarian cancer

    H. R. Hendriks;H. H. Fiebig;R. Giavazzi;S. P. Langdon

  • Cancer Cell Culture

    Simon P. Langdon

Frequent Co-Authors

David J. Harrison
David J. Harrison University of St Andrews
John F. Smyth
John F. Smyth University of Edinburgh
William R. Miller
William R. Miller University of New Mexico
Kenneth G. MacLeod
Kenneth G. MacLeod University of Missouri
Malcolm F. G. Stevens
Malcolm F. G. Stevens University of Nottingham
John A. Hickman
John A. Hickman University of Manchester
Enrique Rozengurt
Enrique Rozengurt University of California, Los Angeles
John M. S. Bartlett
John M. S. Bartlett University of Toronto
Claudiu T. Supuran
Claudiu T. Supuran University of Florence
Robert P. Millar
Robert P. Millar University of Pretoria

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