World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
108
Citations
68957
World Ranking
5875
National Ranking
578

Research.com Recognitions

  • 2019 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Robert Clarke is affiliated with the University of Oxford in the United Kingdom. Their research primarily lies within the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with specific focus on Oncology, Molecular Biology, Cancer Research, Genetics, and Pulmonary and Respiratory Medicine.

Their main research topics include:

  • Cancer Cells and Metastasis
  • Estrogen and related hormone effects
  • Cancer Genomics and Diagnostics
  • Breast Cancer Treatment Studies
  • Advanced Breast Cancer Therapies
  • Cancer-related Molecular Pathways
  • BRCA gene mutations in cancer

Robert Clarke has published extensively, with notable recent papers including:

  • High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer, 2022, Nature Communications
  • Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient Stratification, 2022, Cancer Research
  • Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors, 2021, Nature Communications
  • International multidisciplinary consensus on the integration of radiotherapy with new systemic treatments for breast cancer: European Society for Radiotherapy and Oncology (ESTRO)-endorsed recommendations, 2024, The Lancet Oncology
  • Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer, 2020, Oncogene

Frequent co-authors in their publications include:

  • Sacha J. Howell
  • Bruno M. Simões
  • Angélica Santiago-Gómez
  • Elisabetta Marangoni
  • Katherine Spence

Their work has appeared in several publication venues with repeated contributions to:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • European Journal of Surgical Oncology
  • Oncogene

Recognition in their field includes being awarded the status of Fellow of the American Association for the Advancement of Science (AAAS) in 2019.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Patient-derived xenograft models: an emerging platform for translational cancer research.

    Manuel Hidalgo;Frederic Amant;Andrew V. Biankin;Eva Budinská

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Dissociation between Steroid Receptor Expression and Cell Proliferation in the Human Breast

    Robert B. Clarke;Anthony Howell;Christopher S. Potten;Elizabeth Anderson

  • Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland.

    Michael D Johnson;Nicholas Kenney;Adriana Stoica;Leena Hilakivi-Clarke

  • Aberrant Activation of Notch Signaling in Human Breast Cancer

    Spyros Stylianou;Robert B Clarke;Keith Brennan

  • Meta-Analysis of Soy Intake and Breast Cancer Risk

    Bruce J. Trock;Leena Hilakivi-Clarke;Robert Clarke

  • Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines.

    Erik W. Thompson;Soonmyoung Paik;Nils Brünner;Connie L. Sommers

  • The properties of high-dimensional data spaces: implications for exploring gene and protein expression data

    Robert Clarke;Habtom W. Ressom;Antai Wang;Jianhua Xuan

  • Regulation of Breast Cancer Stem Cell Activity by Signaling through the Notch4 Receptor

    Hannah Harrison;Gillian Farnie;Sacha J. Howell;Rebecca E. Rock

  • Interrogating open issues in cancer precision medicine with patient-derived xenografts

    Annette T. Byrne;Denis G. Alférez;Frédéric Amant;Daniela Annibali

  • Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling

    Robert Clarke;Minetta C Liu;Kerrie B Bouker;Zhiping Gu

  • Multidrug resistance in breast cancer: A meta-analysis of MDR1/gp170 expression and its possible functional significance

    Bruce J. Trock;Fabio Leonessa;Robert Clarke

  • Identification of a putative intestinal stem cell and early lineage marker; musashi-1.

    Christopher S. Potten;Catherine Booth;Gregory L. Tudor;Dawn Booth

  • Cellular and Molecular Pharmacology of Antiestrogen Action and Resistance

    Robert Clarke;Fabio Leonessa;James N. Welch;Todd C. Skaar

  • Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

    Suzanne A. Eccles;Eric O. Aboagye;Simak Ali;Annie S. Anderson

  • Mammary Stem Cells and Breast Cancer—Role of Notch Signalling

    Gillian Farnie;Robert B. Clarke

  • Risk determination and prevention of breast cancer

    Anthony Howell;Annie S Anderson;Robert B Clarke;Stephen W Duffy

Frequent Co-Authors

Rory Collins
Rory Collins University of Oxford
Zhengming Chen
Zhengming Chen University of Oxford
Hugh Watkins
Hugh Watkins University of Oxford
Yue Wang
Yue Wang Zhejiang University
Martin Farrall
Martin Farrall University of Oxford
Anders Hamsten
Anders Hamsten Karolinska Institute
Liming Li
Liming Li Peking University
Nilesh J. Samani
Nilesh J. Samani University of Leicester
Derrick A. Bennett
Derrick A. Bennett University of Oxford
Richard Peto
Richard Peto University of Oxford

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