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Molecular Biology

D-Index
57
Citations
19565
World Ranking
2125
National Ranking
1054

Overview

Sriharsa Pradhan is affiliated with New England Biolabs in the United States and specializes in biochemistry, genetics, and molecular biology. Their research profile spans multiple subfields, including molecular biology, plant science, cancer research, genetics, and oncology.

The scientist's work focuses primarily on several key research topics: genomics and chromatin dynamics, epigenetics and DNA methylation, RNA modifications and cancer, cancer-related gene regulation, RNA research and splicing, DNA repair mechanisms, and chromosomal and genetic variations.

Sriharsa Pradhan has published extensively in respected scientific venues. The most frequent publication platforms include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Epigenomes
  • Methods in molecular biology
  • Genome Research

Several significant recent papers highlight the scope and focus of their research:

  • "Enzymatic methyl sequencing detects DNA methylation at single-base resolution from picograms of DNA" (2021, Genome Research)
  • "Heterochromatin establishment during early mammalian development is regulated by pericentromeric RNA and characterized by non-repressive H3K9me3" (2020, Nature Cell Biology)
  • "Diverse silent chromatin states modulate genome compartmentalization and loop extrusion barriers" (2022, Nature Structural & Molecular Biology)
  • "Nondestructive enzymatic deamination enables single-molecule long-read amplicon sequencing for the determination of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution" (2021, Genome Research)
  • "The microtubule-associated histone methyltransferase SET8, facilitated by transcription factor LSF, methylates α-tubulin" (2020, Journal of Biological Chemistry)

Frequent collaborators include:

  • Hang Gyeong Chin
  • Pierre-Olivier Estève
  • Sagnik Sen
  • Udayakumar S. Vishnu
  • Pierre Esteve

The research contributions of Sriharsa Pradhan cover a broad and detailed landscape of molecular mechanisms, particularly related to chromatin dynamics, epigenetic regulation, and sequencing technologies. The work includes both fundamental biological research and applications relevant to cancer biology and genetics.

Best Publications

  • Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning

    Shawn J. Cokus;Suhua Feng;Xiaoyu Zhang;Zugen Chen

  • UHRF1 Plays a Role in Maintaining DNA Methylation in Mammalian Cells

    Magnolia Bostick;Jong Kyong Kim;Pierre-Olivier Estève;Amander Clark

  • Conservation and divergence of methylation patterning in plants and animals

    Suhua Feng;Shawn J. Cokus;Xiaoyu Zhang;Pao Yang Chen

  • Recombinant Human DNA (Cytosine-5) Methyltransferase I. EXPRESSION, PURIFICATION, AND COMPARISON OF DE NOVO AND MAINTENANCE METHYLATION

    Sriharsa Pradhan;Albino Bacolla;Robert D. Wells;Richard J. Roberts

  • Epigenetic mechanisms in mammals

    J. K. Kim;M. Samaranayake;S. Pradhan

  • Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication

    Pierre-Olivier Estève;Hang Gyeong Chin;Andrea Smallwood;George R. Feehery

  • DNMT1-interacting RNAs block gene-specific DNA methylation

    Annalisa Di Ruscio;Alexander K. Ebralidze;Touati Benoukraf;Giovanni Amabile

  • Dual Binding of Chromomethylase Domains to H3K9me2-containing Nucleosomes Directs DNA Methylation in Plants

    Jiamu Du;Xuehua Zhong;Yana V. Bernatavichute;Hume Stroud

  • 5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells

    Hume Stroud;Suhua Feng;Shannon Morey Kinney;Sriharsa Pradhan

  • Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases

    Gun-Do Kim;Jingwei Ni;Jingwei Ni;Nicole Kelesoglu;Richard J. Roberts

  • Functional cooperation between HP1 and DNMT1 mediates gene silencing

    Andrea Smallwood;Pierre-Olivier Estève;Sriharsa Pradhan;Michael Carey

  • Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3

    Anders M Lindroth;David Shultis;Zuzana Jasencakova;Jörg Fuchs

  • Viral oncoproteins target the DNA methyltransferases.

    W A Burgers;L Blanchon;S Pradhan;Y de Launoit

  • Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells

    Pierre-Olivier Estève;Hang Gyeong Chin;Jack Benner;George R. Feehery

  • Enzymatic methyl sequencing detects DNA methylation at single-base resolution from picograms of DNA

    Romualdas Vaisvila;V.K. Chaithanya Ponnaluri;Zhiyi Sun;Bradley W. Langhorst

  • Mediator Links Epigenetic Silencing of Neuronal Gene Expression with X-Linked Mental Retardation

    Ning Ding;Haiying Zhou;Pierre Olivier Esteve;Hang Gyeong Chin

  • UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells

    Jong Kyong Kim;Pierre-Olivier Estève;Steven E. Jacobsen;Sriharsa Pradhan

  • A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability

    Pierre Olivier Estéve;Yanqi Chang;Mala Samaranayake;Anup K. Upadhyay

  • Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte

    Peter W. S. Hill;Harry G. Leitch;Cristina E. Requena;Zhiyi Sun

  • Human maintenance DNA (cytosine-5)-methyltransferase and p53 modulate expression of p53-repressed promoters

    Pierre-Olivier Estève;Hang Gyeong Chin;Sriharsa Pradhan

Frequent Co-Authors

Steven E. Jacobsen
Steven E. Jacobsen University of California, Los Angeles
Richard J. Roberts
Richard J. Roberts New England Biolabs
Melanie Ehrlich
Melanie Ehrlich Tulane University
Michael Carey
Michael Carey University of California, Los Angeles
Suhua Feng
Suhua Feng University of California, Los Angeles
Xiaodong Cheng
Xiaodong Cheng The University of Texas MD Anderson Cancer Center
Scott E. Schaus
Scott E. Schaus Boston University
Kenneth C. Ehrlich
Kenneth C. Ehrlich US Department of Agriculture
Thomas Jenuwein
Thomas Jenuwein Max Planck Society
Henry Paulus
Henry Paulus Boston Biomedical Research Institute

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