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Overview

Leonard H. van den Berg is affiliated with the University Medical Center Utrecht in the Netherlands. Their work primarily focuses on the intersection of medicine, biochemistry, genetics, and molecular biology, with a strong emphasis on neurology and related subfields. This includes research in neurology, genetics, molecular biology, cellular and molecular neuroscience, and clinical psychology.

The main research topics addressed by Leonard H. van den Berg include amyotrophic lateral sclerosis (ALS) research, neurogenetic and muscular disorders research, Parkinson's disease mechanisms and treatments, neurological diseases and metabolism, prion diseases and protein misfolding, biochemical acid research studies, and epigenetics and DNA methylation.

Their published work appears frequently in a range of scientific venues, with numerous publications in:

  • Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
  • Neurology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Neurology
  • Journal of Neurology Neurosurgery & Psychiatry

Selected recent papers authored or co-authored by Leonard H. van den Berg include:

  • "TDP-43 proteinopathies: a new wave of neurodegenerative diseases" (2020), Journal of Neurology Neurosurgery & Psychiatry
  • "Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors" (2020), Nature Genetics
  • "Muscle strength and motor function in adolescents and adults with spinal muscular atrophy" (2020), Neurology
  • "Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders" (2021), Genome Biology
  • "Population-based analysis of survival in spinal muscular atrophy" (2020), Neurology

Frequent collaborators in their research include:

  • Jan H. Veldink
  • Philip Van Damme
  • Ruben P. A. van Eijk
  • Ammar Al-Chalabi
  • Orla Hardiman

Leonard H. van den Berg's research intersects multidisciplinary fields combining clinical neurology with molecular biology and genetics, contributing to the understanding of neurodegenerative diseases, particularly ALS and spinal muscular atrophy. The extensive publication record and diverse range of topics reflect ongoing investigations into genetic factors and molecular mechanisms underlying neurological disorders.

Best Publications

  • Systematic identification of trans eQTLs as putative drivers of known disease associations

    Harm-Jan Westra;Marjolein J Peters;Tõnu Esko;Hanieh Yaghootkar

  • Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

    Carl A. Anderson;Gabrielle Boucher;Charlie W. Lees;Andre Franke

  • Multiple common variants for celiac disease influencing immune gene expression

    Patrick C. A. Dubois;Gosia Trynka;Lude Franke;Lude Franke;Karen A. Hunt

  • Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

    Elizabeth T. Cirulli;Brittany N Lasseigne;Slave Petrovski;Peter C Sapp

  • Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

    Aude Nicolas;Kevin P. Kenna;Alan E. Renton;Alan E. Renton;Nicola Ticozzi

  • Whole-genome sequence variation, population structure and demographic history of the Dutch population

    Laurent C. Francioli;Androniki Menelaou;Sara L. Pulit;Freerk van Dijk

  • Controversies and priorities in amyotrophic lateral sclerosis

    Martin R Turner;Orla Hardiman;Michael Benatar;Benjamin R Brooks

  • The genetics and neuropathology of amyotrophic lateral sclerosis

    Ammar Al-Chalabi;Ashley Jones;Claire Troakes;Claire Troakes;Andrew King;Andrew King

  • Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.

    Michael A van Es;Jan H Veldink;Christiaan G J Saris;Hylke M Blauw

  • Disease variants alter transcription factor levels and methylation of their binding sites.

    Marc Jan Bonder;René Luijk;Daria V Zhernakova;Matthijs Moed

  • Identification of context-dependent expression quantitative trait loci in whole blood

    Daria V Zhernakova;Patrick Deelen;Martijn Vermaat;Maarten van Iterson

  • Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS.

    B N Smith;N Ticozzi;C Fallini;A S Gkazi

  • Genetic and environmental influences interact with age and sex in shaping the human methylome

    Jenny van Dongen;Michel G. Nivard;Gonneke Willemsen;Jouke-Jan Hottenga

  • Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study

    Ammar Al-Chalabi;Andrea Calvo;Adriano Chio;Shuna Colville

  • Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.

    Nona Sotoodehnia;Aaron Isaacs;Paul I W de Bakker;Marcus Dörr

  • Amyotrophic lateral sclerosis: moving towards a new classification system

    Ammar Al-Chalabi;Orla Hardiman;Matthew C Kiernan;Adriano Chiò

  • Evidence for an oligogenic basis of amyotrophic lateral sclerosis

    Marka van Blitterswijk;Michael A. van Es;Eric A.M. Hennekam;Dennis Dooijes

  • A randomized sequential trial of creatine in amyotrophic lateral sclerosis

    Geert Jan Groeneveld;Jan H. Veldink;Ingeborg van der Tweel;Sandra Kalmijn

  • EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans

    Annelies Van Hoecke;Lies Schoonaert;Robin Lemmens;Mieke Timmers

  • Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration

    Claire L. Simpson;Robin Lemmens;Robin Lemmens;Katarzyna Miskiewicz;Katarzyna Miskiewicz;Wendy J. Broom

Frequent Co-Authors

Jan H. Veldink
Jan H. Veldink Utrecht University
Orla Hardiman
Orla Hardiman Trinity College Dublin
Cisca Wijmenga
Cisca Wijmenga University Medical Center Groningen
Ammar Al-Chalabi
Ammar Al-Chalabi King's College London
Lude Franke
Lude Franke University Medical Center Groningen
Martijn P. van den Heuvel
Martijn P. van den Heuvel Vrije Universiteit Amsterdam
Aaron Isaacs
Aaron Isaacs Maastricht University
Roel A. Ophoff
Roel A. Ophoff University of California, Los Angeles
André G. Uitterlinden
André G. Uitterlinden Erasmus University Rotterdam

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