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Genetics

D-Index
54
Citations
19093
World Ranking
3618
National Ranking
127

Overview

Patrick Deelen is affiliated with the University Medical Center Groningen in the Netherlands. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Within these broad areas, their work focuses on Molecular Biology, Genetics, Infectious Diseases, Neurology, and Clinical Psychology.

Deelen's scientific output covers several main topics, including Genetic Associations and Epidemiology, Bioinformatics and Genomic Networks, Genomics and Rare Diseases, Epigenetics and DNA Methylation, COVID-19 and Mental Health, RNA modifications and cancer, and COVID-19 Clinical Research Studies.

The scientist has contributed to a range of recent papers covering diverse genetic and biomedical topics. Notable publications include:

  • Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases, 2023, Nature Genetics
  • Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project, 2022, Nature Genetics
  • Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression, 2021, Nature Genetics
  • Mapping the human genetic architecture of COVID-19, 2021, Nature
  • Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology, 2021, Nature Genetics

Deelen frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Genetics, Scientific Reports, Nature Human Behaviour, and Cell Genomics. Their most frequent publishing platform is bioRxiv with 19 papers, followed by six publications in Nature Genetics.

The scientist collaborates with several frequent coauthors, including Lude Franke, Cisca Wijmenga, Morris A. Swertz, Annique Claringbould, and Harm-Jan Westra.

Best Publications

  • Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity.

    Alexandra Zhernakova;Alexander Kurilshikov;Marc Jan Bonder;Ettje F. Tigchelaar

  • Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

    Urmo Võsa;Annique Claringbould;Annique Claringbould;Harm-Jan Westra;Marc Jan Bonder

  • The effect of host genetics on the gut microbiome

    Marc Jan Bonder;Alexander Kurilshikov;Alexander Kurilshikov;Ettje F Tigchelaar;Zlatan Mujagic

  • Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

    Richard Karlsson Linnér;Richard Karlsson Linnér;Pietro Biroli;Edward Kong;S. Fleur W. Meddens;S. Fleur W. Meddens

  • Whole-genome sequence variation, population structure and demographic history of the Dutch population

    Laurent C. Francioli;Androniki Menelaou;Sara L. Pulit;Freerk van Dijk

  • Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis

    Võsa U;Claringbould A;Westra H;Bonder Mj

  • Disease variants alter transcription factor levels and methylation of their binding sites.

    Marc Jan Bonder;René Luijk;Daria V Zhernakova;Matthijs Moed

  • Identification of context-dependent expression quantitative trait loci in whole blood

    Daria V Zhernakova;Patrick Deelen;Martijn Vermaat;Maarten van Iterson

  • Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.

    Rudolf S. N. Fehrmann;Ritsert C. Jansen;Jan H. Veldink;Harm-Jan Westra

  • Genetic and environmental influences interact with age and sex in shaping the human methylome

    Jenny van Dongen;Michel G. Nivard;Gonneke Willemsen;Jouke-Jan Hottenga

  • A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans

    Yang Li;Marije Oosting;Sanne P. Smeekens;Martin Jaeger

  • Single-cell RNA sequencing identifies celltype-specific cis-eQTLs and co-expression QTLs.

    Monique G. P. van der Wijst;Harm Brugge;Dylan H. de Vries;Patrick Deelen

  • Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution.

    Maarten van Iterson;Erik W van Zwet;Bastiaan T Heijmans;Peter a.C ’t Hoen

  • The Genome of the Netherlands: design, and project goals

    Dorret I. Boomsma;Cisca Wijmenga;Eline P. Slagboom;Morris A. Swertz

  • Genetic insights into biological mechanisms governing human ovarian ageing.

    Katherine S. Ruth;Felix R. Day;Jazib Hussain;Ana Martínez-Marchal

  • Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression

    Jingyuan Fu;Marcel G. M. Wolfs;Patrick Deelen;Harm-Jan Westra

  • Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

    Eleonora Porcu;Eleonora Porcu;Sina Rüeger;Sina Rüeger;Kaido Lepik;Kaido Lepik;Federico A. Santoni

  • Cohort profile: LifeLines DEEP, a prospective, general population cohort study in the northern Netherlands: Study design and baseline characteristics

    Ettje F Tigchelaar;Alexandra Zhernakova;Jackie A M Dekens;Gerben Hermes

  • Lessons learned from whole exome sequencing in multiplex families affected by a complex genetic disorder, intracranial aneurysm

    Janice L. Farlow;Hai Lin;Laura Sauerbeck;Dongbing Lai

  • Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

    Wouter van Rheenen;Rick A. A. van der Spek;Mark K. Bakker;Joke J. F. A. van Vugt

Frequent Co-Authors

Lude Franke
Lude Franke University Medical Center Groningen
Morris A. Swertz
Morris A. Swertz University Medical Center Groningen
Cisca Wijmenga
Cisca Wijmenga University Medical Center Groningen
Marc Jan Bonder
Marc Jan Bonder University of Groningen
Alexandra Zhernakova
Alexandra Zhernakova University Medical Center Groningen
Harm-Jan Westra
Harm-Jan Westra University Medical Center Groningen
André G. Uitterlinden
André G. Uitterlinden Erasmus University Rotterdam
Jan H. Veldink
Jan H. Veldink Utrecht University
Aaron Isaacs
Aaron Isaacs Maastricht University
Zoltán Kutalik
Zoltán Kutalik University of Lausanne

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