2017 - Interdisciplinary Prize, Royal Society of Chemistry (UK)
2002 - Meldola Medal and Prize, Royal Society of Chemistry (UK)
Gregory L. Challis mostly deals with Biochemistry, Gene, Streptomyces coelicolor, Genome and Genetics. While the research belongs to areas of Streptomyces coelicolor, Gregory L. Challis spends his time largely on the problem of Gene cluster, intersecting his research to questions surrounding Polyketide, Microbiology, Plasmid and Quorum sensing. The study incorporates disciplines such as Natural product and Computational biology in addition to Genome.
His work in Genomics, Whole genome sequencing, Regulator gene and DNA sequencing is related to Genetics. His Regulator gene study combines topics from a wide range of disciplines, such as Genome project and Synteny. The Biosynthesis study combines topics in areas such as Streptomycetaceae, Siderophore and Streptomyces.
His primary areas of investigation include Biochemistry, Biosynthesis, Stereochemistry, Gene and Gene cluster. His study looks at the intersection of Biosynthesis and topics like Cytochrome P450 with Pentamycin. His work in Stereochemistry covers topics such as Substrate which are related to areas like Active site.
His research in Gene is mostly concerned with Genome. His Genome research focuses on Whole genome sequencing in particular. His research in Gene cluster intersects with topics in Operon and Mutant.
His primary scientific interests are in Gene, Biosynthesis, Polyketide, Stereochemistry and Gene cluster. Gregory L. Challis studies Gene, focusing on Genome in particular. His studies deal with areas such as Sesquiterpene, Cyclase and Saccharomyces cerevisiae as well as Biosynthesis.
Many of his research projects under Polyketide are closely connected to Domain with Domain, tying the diverse disciplines of science together. His Stereochemistry study combines topics in areas such as Substrate, Thioester, Condensation domain and Active site. His Gene cluster study is focused on Biochemistry in general.
Gregory L. Challis spends much of his time researching Condensation domain, Stereochemistry, Docking, Polyketide synthase and Polyketide. His Condensation domain study deals with the bigger picture of Gene. His Docking research is multidisciplinary, incorporating elements of Transport protein, Short linear motif, Hydroxylation, Oxidoreductase and Cofactor.
His Cofactor research incorporates themes from Heme and Active site. The concepts of his Polyketide synthase study are interwoven with issues in Thioester, Transacylation, Acyl carrier protein and Acylation. His Polyketide research is multidisciplinary, incorporating perspectives in Protein subunit and Peptide.
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Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
S. D. Bentley;K. F. Chater;A.-M. Cerdeño-Tárraga;G. L. Challis;G. L. Challis.
Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature
Paul G. Arnison;Mervyn J. Bibb;Gabriele Bierbaum;Albert Alexander Bowers.
Natural Product Reports (2013)
Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains.
Gregory L Challis;Jacques Ravel;Craig A Townsend.
Chemistry & Biology (2000)
Synergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces species
Gregory L. Challis;David A. Hopwood.
Proceedings of the National Academy of Sciences of the United States of America (2003)
Discovery of microbial natural products by activation of silent biosynthetic gene clusters.
Peter J. Rutledge;Gregory L. Challis.
Nature Reviews Microbiology (2015)
Discovery of a new peptide natural product by Streptomyces coelicolor genome mining.
Sylvie Lautru;Robert J Deeth;Lianne M Bailey;Gregory L Challis.
Nature Chemical Biology (2005)
Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens
Mark W. Silby;Ana M. Cerdeño-Tárraga;Georgios S. Vernikos;Stephen R. Giddens.
Genome Biology (2009)
A Widely Distributed Bacterial Pathway for Siderophore Biosynthesis Independent of Nonribosomal Peptide Synthetases
Gregory L. Challis.
Strategies for the discovery of new natural products by genome mining.
Malek Zerikly;Gregory L. Challis.
Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens
Luisa Laureti;Lijiang Song;Sheng Huang;Sheng Huang;Christophe Corre.
Proceedings of the National Academy of Sciences of the United States of America (2011)
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