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Biology and Biochemistry

D-Index
58
Citations
14534
World Ranking
13029
National Ranking
5554

Overview

Douglas A. Mitchell is affiliated with the University of Illinois at Urbana-Champaign in the United States. Their research contributions span multiple aspects of biochemistry, genetics, and molecular biology, with a strong focus on microbial natural products and biosynthesis.

Their scientific output includes over 100 publications primarily in the fields of biochemistry, genetics, molecular biology, and medicine. More specifically, their subfield contributions cover molecular biology, pharmacology, oncology, microbiology, and areas related to renewable energy, sustainability, and the environment.

The topics central to their work are diverse, including microbial natural products and biosynthesis, RNA and protein synthesis mechanisms, chemical synthesis and analysis, biochemical and structural characterization, genomics and phylogenetic studies, peptidase inhibition and analysis, and antimicrobial peptides and activities.

They have published extensively in notable venues, with frequent appearances in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of the American Chemical Society
  • ACS Chemical Biology
  • Nature Communications
  • ACS Central Science

Recent papers by Douglas A. Mitchell include:

  • New developments in RiPP discovery, enzymology and engineering (2020, Natural Product Reports)
  • Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family (2020, BMC Genomics)
  • Mechanism of Action of Ribosomally Synthesized and Post-Translationally Modified Peptides (2022, Chemical Reviews)
  • RRE-Finder: a Genome-Mining Tool for Class-Independent RiPP Discovery (2020, mSystems)
  • RadicalSAM.org: A Resource to Interpret Sequence-Function Space and Discover New Radical SAM Enzyme Chemistry (2021, ACS Bio & Med Chem Au)

The scientist collaborates frequently with a core group of co-authors, including:

  • Shravan R. Dommaraju
  • Wilfred A. van der Donk
  • Andrew J. Rice
  • Lonnie A. Harris
  • Lingyang Zhu

Douglas A. Mitchell's research integrates genomic mining, enzymology, and natural product chemistry, contributing to the understanding of ribosomally synthesized and post-translationally modified peptides and related enzyme functions. Their work reflects a multidisciplinary approach bridging molecular biology, chemical synthesis, and bioinformatics.

Best Publications

  • Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature

    Paul G. Arnison;Mervyn J. Bibb;Gabriele Bierbaum;Albert Alexander Bowers

  • antiSMASH 4.0-improvements in chemistry prediction and gene cluster boundary identification.

    Kai Blin;Thomas Wolf;Marc G. Chevrette;Xiaowen Lu

  • Minimum Information about a Biosynthetic Gene cluster.

    Marnix H. Medema;Marnix H. Medema;Renzo Kottmann;Pelin Yilmaz;Matthew Cummings

  • New developments in RiPP discovery, enzymology and engineering

    Manuel Montalbán-López;Thomas A Scott;Sangeetha Ramesh;Imran R Rahman

  • A new genome-mining tool redefines the lasso peptide biosynthetic landscape

    Jonathan I. Tietz;Christopher J. Schwalen;Parth S. Patel;Tucker Maxson

  • A prevalent peptide-binding domain guides ribosomal natural product biosynthesis

    Brandon J Burkhart;Graham A Hudson;Kyle L Dunbar;Douglas A Mitchell

  • Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine.

    Douglas Alan Mitchell;Michael A. Marletta;Michael A. Marletta

  • Multitarget Drug Discovery for Tuberculosis and Other Infectious Diseases

    Kai Li;Lici A. Schurig-Briccio;Xinxin Feng;Ashutosh Upadhyay

  • Discovery of a widely distributed toxin biosynthetic gene cluster

    Shaun W. Lee;Douglas A. Mitchell;Andrew L. Markley;Mary E. Hensler

  • Plantazolicin, a Novel Microcin B17/Streptolysin S-Like Natural Product from Bacillus amyloliquefaciens FZB42

    Romy Scholz;Katie J. Molohon;Jonny Nachtigall;Joachim Vater

  • Identification of a Potent and Selective Pharmacophore for Cdc25 Dual Specificity Phosphatase Inhibitors.

    John S. Lazo;Kaoru Nemoto;Katharine E. Pestell;Kathleen Cooley

  • FeIII–TAML-catalyzed green oxidative degradation of the azo dye Orange II by H2O2 and organic peroxides: products, toxicity, kinetics, and mechanisms

    Naima Chahbane;Delia Laura Popescu;Douglas A. Mitchell;Arani Chanda

  • Thiazole/oxazole-modified microcins: complex natural products from ribosomal templates.

    Joel O Melby;Nathan J Nard;Douglas A Mitchell

  • Catalase−Peroxidase Activity of Iron(III)−TAML Activators of Hydrogen Peroxide

    Anindya Ghosh;Douglas A. Mitchell;Arani Chanda;Alexander D. Ryabov

  • YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function

    Brandon J. Burkhart;Christopher J. Schwalen;Greg Mann;James H. Naismith;James H. Naismith

  • Thioredoxin is required for S-nitrosation of procaspase-3 and the inhibition of apoptosis in Jurkat cells

    Douglas A. Mitchell;Sarah U. Morton;Nathaniel B. Fernhoff;Michael A. Marletta

  • RiPP antibiotics: biosynthesis and engineering potential.

    Graham A Hudson;Douglas A Mitchell

  • Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family

    Daniel H Haft;Malay Kumar Basu;Douglas A Mitchell

  • Streptolysin S-like virulence factors: the continuing sagA

    Evelyn M. Molloy;Paul D. Cotter;Colin Hill;Douglas A. Mitchell

  • Bioinformatic Mapping of Radical S-Adenosylmethionine-Dependent Ribosomally Synthesized and Post-Translationally Modified Peptides Identifies New Cα, Cβ, and Cγ-Linked Thioether-Containing Peptides

    Graham A Hudson;Brandon J Burkhart;Adam J DiCaprio;Christopher J Schwalen

Frequent Co-Authors

Wilfred A. van der Donk
Wilfred A. van der Donk University of Illinois at Urbana-Champaign
Satish K. Nair
Satish K. Nair University of Illinois at Urbana-Champaign
Michael A. Marletta
Michael A. Marletta University of California, Berkeley
Gilles P. van Wezel
Gilles P. van Wezel Leiden University
Victor Nizet
Victor Nizet University of California, San Diego
Jack E. Dixon
Jack E. Dixon University of California, San Diego
Konstantin Severinov
Konstantin Severinov Rutgers, The State University of New Jersey
Marnix H. Medema
Marnix H. Medema Wageningen University & Research
Pieter C. Dorrestein
Pieter C. Dorrestein University of California, San Diego
Thomas Michel
Thomas Michel Brigham and Women's Hospital

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