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Biology and Biochemistry

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19338
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Overview

Katrin F. Chua is affiliated with Stanford University in the United States. Their research contributions span several areas within biochemistry, genetics, molecular biology, and medicine, with a strong focus on molecular biology and related subfields including geriatrics and gerontology, epidemiology, oncology, and immunology.

The scientist's recent scholarly articles reflect a range of topics involving RNA modifications, cancer, sirtuins, resveratrol in medicine, epigenetics, DNA methylation, histone deacetylase inhibitor research, autophagy, fibroblast growth factor research, and protein degradation and inhibitors.

  • Elevated NSD3 histone methylation activity drives squamous cell lung cancer (2021, Nature)
  • HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies (2021, Cell Reports)
  • Sialylated IgG induces the transcription factor REST in alveolar macrophages to protect against lung inflammation and severe influenza disease (2024, Immunity)
  • Multivalent tumor suppressor adenomatous polyposis coli promotes Axin biomolecular condensate formation and efficient β-catenin degradation (2020, Scientific Reports)
  • Mammalian SIRT6 Represses Invasive Cancer Cell Phenotypes through ATP Citrate Lyase (ACLY)-Dependent Histone Acetylation (2021, Genes)

Their frequent co-authors include Or Gozani, Simone Hausmann, Paweł K. Mazur, Tie-Mei Li, and Gang Yuan, indicating collaborative work across multiple projects and publications.

Publication venues where their work has appeared include:

  • Nature
  • Cell Reports
  • Immunity
  • Scientific Reports
  • Genes

Their research fields underscore a wide-ranging engagement with biochemical and molecular mechanisms underlying disease processes and therapeutic interventions. Their main fields of study consist of:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these, subfields emphasize:

  • Molecular Biology
  • Geriatrics and Gerontology
  • Epidemiology
  • Oncology
  • Immunology

The scientist's principal topics of investigation encompass:

  • RNA modifications and cancer
  • Sirtuins and Resveratrol in Medicine
  • Epigenetics and DNA Methylation
  • Histone Deacetylase Inhibitors Research
  • Autophagy in Disease and Therapy
  • Fibroblast Growth Factor Research
  • Protein Degradation and Inhibitors

Best Publications

  • Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

    Anne Brunet;Lora B. Sweeney;J. Fitzhugh Sturgill;Katrin F. Chua

  • Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

    Raul Mostoslavsky;Katrin F. Chua;Katrin F. Chua;David B. Lombard;Wendy W. Pang

  • Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

    Hwei-Ling Cheng;Raul Mostoslavsky;Shin'ichi Saito;John P. Manis

  • SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

    Eriko Michishita;Ronald A. McCord;Elisabeth Berber;Mitomu Kioi

  • SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

    Tiara L.A. Kawahara;Eriko Michishita;Eriko Michishita;Adam S. Adler;Mara Damian;Mara Damian

  • ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression

    Xiaobing Shi;Tao Hong;Kay L. Walter;Mark Ewalt

  • DNA Repair, Genome Stability, and Aging

    David B. Lombard;Katrin F. Chua;Raul Mostoslavsky;Sonia Franco

  • Transcription-targeted DNA deamination by the AID antibody diversification enzyme

    Jayanta Chaudhuri;Ming Tian;Chan Khuong;Katrin Chua

  • Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

    Craig H. Bassing;Katrin F. Chua;Jo Ann Sekiguchi;Heikyung Suh

  • SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation

    Matthew F. Barber;Eriko Michishita-Kioi;Eriko Michishita-Kioi;Eriko Michishita-Kioi;Yuanxin Xi;Luisa Tasselli;Luisa Tasselli

  • Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally

    Yu Zhang;So Hee Kwon;Teppei Yamaguchi;Fabien Cubizolles

  • Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors.

    Craig H. Bassing;Heikyung Suh;David O. Ferguson;David O. Ferguson;Katrin F. Chua

  • The Splicing Factor BBP Interacts Specifically with the Pre-mRNA Branchpoint Sequence UACUAAC

    J.Andrew Berglund;Katrin Chua;Nadja Abovich;Robin Reed

  • Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6

    Eriko Michishita;Ronald A. McCord;Lisa D. Boxer;Matthew F. Barber

  • Nuclear DNA damage signalling to mitochondria in ageing

    Evandro Fei Fang;Morten Scheibye-Knudsen;Katrin F. Chua;Mark P. Mattson

  • SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair

    Ronald A. McCord;Eriko Michishita;Tao Hong;Elisabeth Berber

  • Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress

    Katrin F. Chua;Raul Mostoslavsky;David B. Lombard;David B. Lombard;Wendy W. Pang

  • Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling

    Dan Levy;Alex J Kuo;Yanqi Chang;Uwe Schaefer

  • SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease

    Jiyung Shin;Ming He;Ming He;Yufei Liu;Silvana Paredes;Silvana Paredes

  • SIRT6: Novel Mechanisms and Links to Aging and Disease.

    Luisa Tasselli;Luisa Tasselli;Wei Zheng;Wei Zheng;Katrin F. Chua;Katrin F. Chua

Frequent Co-Authors

Frederick W. Alt
Frederick W. Alt Boston Children's Hospital
Or Gozani
Or Gozani Stanford University
Raul Mostoslavsky
Raul Mostoslavsky Harvard University
David B. Lombard
David B. Lombard University of Michigan–Ann Arbor
Robin Reed
Robin Reed Harvard University
Benjamin A. Garcia
Benjamin A. Garcia Washington University in St. Louis
Clemens Steegborn
Clemens Steegborn University of Bayreuth
Ettore Appella
Ettore Appella National Institutes of Health
David A. Sinclair
David A. Sinclair Harvard University

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