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Molecular Biology

D-Index
67
Citations
42571
World Ranking
1541
National Ranking
33

Overview

Wei-Guo Zhu is affiliated with Shenzhen University in China and has made significant contributions to the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their research spans a broad range of topics with a primary focus on Molecular Biology, Oncology, Immunology, Geriatrics and Gerontology, and Epidemiology.

The main research themes in their work include:

  • DNA Repair Mechanisms
  • Epigenetics and DNA Methylation
  • Ubiquitin and proteasome pathways
  • Sirtuins and Resveratrol in Medicine
  • RNA modifications and cancer
  • Histone Deacetylase Inhibitors Research
  • Autophagy in Disease and Therapy

Zhu has published extensively, with notable papers such as:

  • "The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy" (2020) in Frontiers in Cell and Developmental Biology
  • "SIRT6 coordinates with CHD4 to promote chromatin relaxation and DNA repair" (2020) in Nucleic Acids Research
  • "HDAC8 cooperates with SMAD3/4 complex to suppress SIRT7 and promote cell survival and migration" (2020) in Nucleic Acids Research
  • "Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice" (2020) in eLife
  • "Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic fatty liver disease by facilitating hepatic fatty acid oxidation" (2022) in Molecular Cell

Frequent publication venues include:

  • Genome Instability & Disease
  • Nucleic Acids Research
  • Theranostics
  • Cell Death and Disease
  • Cell Reports

Wei-Guo Zhu collaborates frequently with a group of researchers, whose most frequent co-authors are:

  • Xiaopeng Lu
  • Jun Zhang
  • Qian Zhu
  • Xingzhi Xu
  • Xin-Hai Pei

The body of Wei-Guo Zhu's work presents a combination of molecular mechanisms involving histone deacetylases, sirtuins, and DNA repair pathways that are relevant to cancer therapy, metabolic diseases, and genome stability. They have also contributed to understanding epigenetic regulation and protein pathways affecting cell survival and migration.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

    Ying Zhao;Jing Yang;Wenjuan Liao;Xiangyu Liu

  • The comet assay: A sensitive method for detecting DNA damage in individual cells

    Wenjuan Liao;Michael A. McNutt;Wei-Guo Zhu

  • Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1).

    Ying Zhao;Shaoli Lu;Lipeng Wu;Guolin Chai

  • Methylation of Adjacent CpG Sites Affects Sp1/Sp3 Binding and Activity in the p21Cip1 Promoter

    Wei Guo Zhu;Kanur Srinivasan;Zunyan Dai;Wenrui Duan

  • p53: Structure, Function and Therapeutic Applications

    Ling Bai;Wei-Guo Zhu

  • DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors

    Wei Guo Zhu;Romola R. Lakshmanan;Matthew D. Beal;Gregory A. Otterson

  • The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells.

    Wei-Guo Zhu;Gregory A Otterson

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Surf the Post-translational Modification Network of p53 Regulation

    Bo Gu;Wei-Guo Zhu

  • EZH2 supports nasopharyngeal carcinoma cell aggressiveness by forming a co-repressor complex with HDAC1/HDAC2 and Snail to inhibit E-cadherin

    Z. T. Tong;M. Y. Cai;X. G. Wang;L. L. Kong

  • The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy.

    Guo Li;Yuan Tian;Wei-Guo Zhu

  • Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.

    Ping Zhang;Bo Tu;Hua Wang;Ziyang Cao

  • Phosphate-induced autophagy counteracts vascular calcification by reducing matrix vesicle release

    Xiao-Yan Dai;Ming-Ming Zhao;Yan Cai;Qing-Cong Guan

  • Sirtuins in glucose and lipid metabolism.

    Xin Ye;Meiting Li;Tianyun Hou;Tian Gao

  • Autophagy Regulates Chromatin Ubiquitination in DNA Damage Response through Elimination of SQSTM1/p62

    Yanan Wang;Nan Zhang;Luyao Zhang;Ran Li

  • A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes

    Zunyan Dai;Wei Guo Zhu;Carl D. Morrison;Romulo M. Brena

Frequent Co-Authors

Xingzhi Xu
Xingzhi Xu Shenzhen University
Gregory A. Otterson
Gregory A. Otterson The Ohio State University
Wei Gu
Wei Gu Columbia University
Sergio Lavandero
Sergio Lavandero University of Chile
Evelina Gatti
Evelina Gatti Aix-Marseille University
Harm H. Kampinga
Harm H. Kampinga University Medical Center Groningen
Steven Finkbeiner
Steven Finkbeiner University of California, San Francisco
Lian Li
Lian Li Emory University
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center
Christoph Plass
Christoph Plass German Cancer Research Center

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