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William H. Frey

William H. Frey

D-Index & Metrics

Neuroscience

D-Index
69
Citations
20285
World Ranking
2598
National Ranking
1228

Overview

William H. Frey is affiliated with HealthPartners in the United States and has a research focus primarily in Medicine and Neuroscience. Their work spans several interconnected fields of study, including Physiology, Neurology, Endocrinology, Diabetes and Metabolism, Nutrition and Dietetics, and Cellular and Molecular Neuroscience.

Their research topics cover a range of areas, notably Alzheimer's disease research and treatments, Biochemical Analysis and Sensing Techniques, Olfactory and Sensory Function Studies, Parkinson's Disease Mechanisms and Treatments, Neuroscience of respiration and sleep, Neuropeptides and Animal Physiology, and Diabetes Management and Research.

Frequent co-authors contributing to their research include Leah R. Hanson, Aleta L. Svitak, Michael Rosenbloom, Bhavani Kashyap, and Terry R. Barclay.

Key publication venues for their work include Pharmaceuticals, Neurology, Drugs & Aging, Translational Psychiatry, and EBioMedicine.

Recent papers authored or co-authored by William H. Frey demonstrate a focus on neurodegenerative diseases and therapeutic approaches:

  • Mechanisms of Intranasal Deferoxamine in Neurodegenerative and Neurovascular Disease (2021), published in Pharmaceuticals
  • A Phase II, Single-Center, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Therapeutic Efficacy of Intranasal Glulisine in Amnestic Mild Cognitive Impairment and Probable Mild Alzheimer's Disease (2021), published in Drugs & Aging
  • Nasal oxytocin for the treatment of psychiatric disorders and pain: achieving meaningful brain concentrations (2021), published in Translational Psychiatry
  • Cell motility and migration as determinants of stem cell efficacy (2020), published in EBioMedicine
  • Comparative Effectiveness of Intracerebroventricular, Intrathecal, and Intranasal Routes of AAV9 Vector Administration for Genetic Therapy of Neurologic Disease in Murine Mucopolysaccharidosis Type I (2021), published in Frontiers in Molecular Neuroscience

Best Publications

  • Intranasal delivery to the central nervous system: Mechanisms and experimental considerations

    Shyeilla V. Dhuria;Shyeilla V. Dhuria;Leah R. Hanson;William H. Frey;William H. Frey

  • Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration.

    R.G. Thorne;G.J. Pronk;V. Padmanabhan;W.H. Frey;W.H. Frey

  • Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease

    Leah R Hanson;William H Frey;William H Frey

  • Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype.

    M.A. Reger;M.A. Reger;G.S. Watson;G.S. Watson;W.H. Frey;W.H. Frey;L.D. Baker;L.D. Baker

  • Delivery of neurotrophic factors to the central nervous system: pharmacokinetic considerations.

    Robert G. Thorne;Robert G. Thorne;William H. Frey;William H. Frey

  • Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

    Mark A. Reger;Mark A. Reger;G. Stennis Watson;G. Stennis Watson;Pattie S. Green;Pattie S. Green;Laura D. Baker;Laura D. Baker

  • Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence.

    Jessica Freiherr;Manfred Hallschmid;William H. Frey;Yvonne F. Brünner

  • Dementia lacking distinctive histologie features: A common non‐Alzheimer degenerative dementia

    D. S. Knopman;A. R. Mastri;W. H. Frey;J. H. Sung

  • Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes.

    J. F. Diedrich;H. Minnigan;R. I. Carp;J. N. Whitaker

  • Quantitative analysis of the olfactory pathway for drug delivery to the brain

    Robert G. Thorne;Carolyn R. Emory;Thomas A. Ala;William H. Frey

  • Intranasal delivery of cells to the brain.

    Lusine Danielyan;Richard Schäfer;Andreas von Ameln-Mayerhofer;Marine Buadze

  • Intranasal administration of interferon beta bypasses the blood-brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosis.

    T.M Ross;P.M Martinez;J.C Renner;R.G Thorne;R.G Thorne

  • Intranasal Treatment of Central Nervous System Dysfunction in Humans

    Colin D. Chapman;William H. Frey;Suzanne Craft;Lusine Danielyan

  • A role for heme in Alzheimer's disease: Heme binds amyloid β and has altered metabolism

    Hani Atamna;William H. Frey

  • Mechanisms of mitochondrial dysfunction and energy deficiency in Alzheimer's disease.

    Hani Atamna;William H. Frey

  • Delivery of Nerve Growth Factor to the Brain via the Olfactory Pathway.

    Xue-Qing Chen;John R. Fawcett;Yueh-Erh Rahman;Thomas A. Ala

  • Intranasal administration of insulin-like growth factor-I bypasses the blood-brain barrier and protects against focal cerebral ischemic damage.

    Xin-Feng Liu;John R Fawcett;Robert G Thorne;Terese A DeFor

  • Therapeutic efficacy of intranasally delivered mesenchymal stem cells in a rat model of Parkinson disease.

    Lusine Danielyan;Richard Schäfer;Andreas von Ameln-Mayerhofer;Felix Bernhard

  • DELIVERY OF INTERFERON-β TO THE MONKEY NERVOUS SYSTEM FOLLOWING INTRANASAL ADMINISTRATION

    R.G. Thorne;L.R. Hanson;T.M. Ross;D. Tung

  • Delivery of 125I-NGF to the Brain via the Olfactory Route

    William H. Frey;Jia Liu;Xueqing Chen;Robert G. Thorne

  • Intranasal deferoxamine provides increased brain exposure and significant protection in rat ischemic stroke.

    Leah R. Hanson;Annina Roeytenberg;Paula M. Martinez;Valerie G. Coppes

  • Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy.

    George J. Francis;Jose A. Martinez;Wei Q. Liu;Kevin Xu

Frequent Co-Authors

Mark A. Reger
Mark A. Reger University of Washington
Laura D. Baker
Laura D. Baker Wake Forest University
David S. Knopman
David S. Knopman Mayo Clinic
Gerard D. Schellenberg
Gerard D. Schellenberg University of Pennsylvania
Michael Chopp
Michael Chopp Oakland University
Tessa Gordon
Tessa Gordon University of Alberta
Richard E. Race
Richard E. Race National Institutes of Health
Jan Born
Jan Born University of Tübingen
Irving I. Gottesman
Irving I. Gottesman University of Minnesota
Edward Rockenstein
Edward Rockenstein University of California, San Diego

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