Fernanda G. De Felice

Research.com Recognitions

• 2026 - Research.com Neuroscience in Brazil Leader Award
• 2025 - Research.com Neuroscience in Brazil Leader Award

Overview

Best Publications

• Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine

  Fernanda G. De Felice;Fernanda G. De Felice;Pauline T. Velasco;Mary P. Lambert;Kirsten L. Viola

  1097
  Citations

• An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

  Theresa R. Bomfim;Leticia Forny-Germano;Luciana B. Sathler;Jordano Brito-Moreira

  948
  Citations

• Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models

  Mychael V. Lourenco;Mychael V. Lourenco;Rudimar L. Frozza;Rudimar L. Frozza;Guilherme B. de Freitas;Guilherme B. de Freitas;Hong Zhang

  885
  Citations

• Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

  Fernanda G. De Felice;Marcelo N.N. Vieira;Theresa R. Bomfim;Helena Decker

  781
  Citations

• Amyloid beta oligomers induce impairment of neuronal insulin receptors

  Wei Qin Zhao;Fernanda G. De Felice;Sara Fernandez;Hui Chen

  727
  Citations

• Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

  Fernanda G. De Felice;Sergio T. Ferreira

  676
  Citations

• Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

  Fernanda G. De Felice;Diana Wu;Mary P. Lambert;Sara J. Fernandez

  592
  Citations

• Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence.

  Jessica Freiherr;Manfred Hallschmid;William H. Frey;Yvonne F. Brünner

  561
  Citations

• TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

  Mychael V. Lourenco;Julia R. Clarke;Rudimar L. Frozza;Theresa R. Bomfim

  442
  Citations

• Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease

  Sergio T. Ferreira;Julia R. Clarke;Theresa R. Bomfim;Fernanda G. De Felice

  438
  Citations

• Monoclonal antibodies that target pathological assemblies of Aβ

  Mary P. Lambert;Pauline T. Velasco;Lei Chang;Kirsten L. Viola

  428
  Citations

• Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases.

  Sergio T. Ferreira;Marcelo N. N. Vieira;Fernanda G. De Felice

  418
  Citations

• How does brain insulin resistance develop in Alzheimer's disease?

  Fernanda G. De Felice;Mychael V. Lourenco;Sergio T. Ferreira

  408
  Citations

• Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease.

  Sergio T. Ferreira;Mychael V. Lourenco;Mauricio M. Oliveira;Fernanda G. De Felice

  407
  Citations

• Alzheimer's disease and insulin resistance: translating basic science into clinical applications

  Fernanda G. De Felice

  377
  Citations

• Mitochondrial Bound Hexokinase Activity as a Preventive Antioxidant Defense STEADY-STATE ADP FORMATION AS A REGULATORY MECHANISM OF MEMBRANE POTENTIAL AND REACTIVE OXYGEN SPECIES GENERATION IN MITOCHONDRIA

  Wagner Seixas da-Silva;Armando Gómez-Puyou;Marietta Tuena de Gómez-Puyou;Rafael Moreno-Sanchez

  377
  Citations

• Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer's disease.

  Natalia M. Lyra e Silva;Natalia M. Lyra e Silva;Rafaella A. Gonçalves;Rafaella A. Gonçalves;Rafaella A. Gonçalves;Tharick A. Pascoal;Ricardo A. S. Lima-Filho

  327
  Citations

• Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Central Nervous System.

  Fernanda G. De Felice;Fernanda G. De Felice;Fernanda Tovar-Moll;Jorge Moll;Douglas P. Munoz

  276
  Citations

• The Role of Leptin and Adiponectin in Obesity-Associated Cognitive Decline and Alzheimer's Disease.

  Leticia Forny-Germano;Fernanda G. De Felice;Fernanda G. De Felice;Marcelo Nunes do Nascimento Vieira

  269
  Citations

• The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease

  Andre F. Batista;Leticia Forny-Germano;Julia R. Clarke;Natalia M. Lyra e Silva

  238
  Citations

• Alzheimer's Disease-Like Pathology Induced by amyloid-β Oligomers in Nonhuman Primates

  Leticia Forny-Germano;Natalia M. Lyra E Silva;André F. Batista;Jordano Brito-Moreira

  238
  Citations

• Targeting the neurotoxic species in Alzheimer’s disease: inhibitors of Aβ oligomerization

  Fernanda G De Felice;Marcelo N N Vieira;Leonardo M Saraiva;J Daniel Figueroa-Villar

  234
  Citations