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Neuroscience
Brazil
2026
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Biology and Biochemistry
Brazil
2023

D-Index & Metrics

Neuroscience

D-Index
77
Citations
20028
World Ranking
1849
National Ranking
6

Research.com Recognitions

  • 2026 - Research.com Neuroscience in Brazil Leader Award
  • 2025 - Research.com Neuroscience in Brazil Leader Award
  • 2023 - Research.com Biology and Biochemistry in Brazil Leader Award
  • 2022 - Research.com Biology and Biochemistry in Brazil Leader Award
  • 2001 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

Sergio T. Ferreira is affiliated with the Federal University of Rio de Janeiro in Brazil. Their research primarily spans the fields of Medicine, Neuroscience, and Biochemistry, Genetics, and Molecular Biology. Within these areas, their focus includes subfields such as Physiology, Molecular Biology, Neurology, Biological Psychiatry, and Cellular and Molecular Neuroscience.

The scientist's research topics cover a range of subjects, with significant attention to Alzheimer's disease research and treatments, neuroinflammation and neurodegeneration mechanisms, and the role of tryptophan in brain disorders. Additional areas of study include adipose tissue and metabolism, endoplasmic reticulum stress and disease, mitochondrial function and pathology, and dementia and cognitive impairment research.

Their recent papers reflect these interests and include:

  • Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer's disease, 2021, Translational Psychiatry
  • Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Central Nervous System, 2020, Trends in Neurosciences
  • Impaired insulin signalling and allostatic load in Alzheimer disease, 2022, Nature Reviews Neuroscience
  • Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer's disease, 2021, Science Signaling
  • Dementia is an age-independent risk factor for severity and death in COVID-19 inpatients, 2021, Alzheimer's & Dementia

The scientist has collaborated extensively with several frequent co-authors: Fernanda G. De Felice, Mychael V. Lourenco, Felipe C. Ribeiro, Juliana T.S. Fortuna, and Fernanda Tovar-Moll.

The venues in which their work has appeared most frequently include Alzheimer's & Dementia, bioRxiv (Cold Spring Harbor Laboratory), Neuropharmacology, Translational Psychiatry, and Journal of Alzheimer's Disease.

In addition to journal articles, there is a recorded book publication titled Mosaico da história da educação de surdos no Brasil: Região Sul, to be published in 2025 by Editora Schreiben eBooks.

Among the honors received is the Fellowship from the John Simon Guggenheim Memorial Foundation awarded in 2001.

Best Publications

  • Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine

    Fernanda G. De Felice;Fernanda G. De Felice;Pauline T. Velasco;Mary P. Lambert;Kirsten L. Viola

  • An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

    Theresa R. Bomfim;Leticia Forny-Germano;Luciana B. Sathler;Jordano Brito-Moreira

  • Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models

    Mychael V. Lourenco;Mychael V. Lourenco;Rudimar L. Frozza;Rudimar L. Frozza;Guilherme B. de Freitas;Guilherme B. de Freitas;Hong Zhang

  • Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

    Fernanda G. De Felice;Marcelo N.N. Vieira;Theresa R. Bomfim;Helena Decker

  • Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

    Fernanda G. De Felice;Sergio T. Ferreira

  • The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease.

    Sergio T Ferreira;William L Klein

  • TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

    Mychael V. Lourenco;Julia R. Clarke;Rudimar L. Frozza;Theresa R. Bomfim

  • Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease

    Sergio T. Ferreira;Julia R. Clarke;Theresa R. Bomfim;Fernanda G. De Felice

  • Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases.

    Sergio T. Ferreira;Marcelo N. N. Vieira;Fernanda G. De Felice

  • How does brain insulin resistance develop in Alzheimer's disease?

    Fernanda G. De Felice;Mychael V. Lourenco;Sergio T. Ferreira

  • Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease.

    Sergio T. Ferreira;Mychael V. Lourenco;Mauricio M. Oliveira;Fernanda G. De Felice

  • Taurine prevents the neurotoxicity of β-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer’s disease and other neurological disorders

    Paulo Roberto Louzada;Andréa C Paula Lima;Dayde L Mendonca-Silva;François Noël

  • Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer's disease.

    Natalia M. Lyra e Silva;Natalia M. Lyra e Silva;Rafaella A. Gonçalves;Rafaella A. Gonçalves;Rafaella A. Gonçalves;Tharick A. Pascoal;Ricardo A. S. Lima-Filho

  • Amyloid-β Binds to the Extracellular Cysteine-rich Domain of Frizzled and Inhibits Wnt/β-Catenin Signaling

    Margaret H. Magdesian;Milena M. V. F. Carvalho;Fabio A. Mendes;Leonardo M. Saraiva

  • Amyloid-beta peptide oligomers disrupt axonal transport through an NMDA receptor-dependent mechanism that is mediated by glycogen synthase kinase 3beta in primary cultured hippocampal neurons.

    Helena Decker;Karen Y Lo;Sandra M Unger;Sergio T Ferreira

  • Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Central Nervous System.

    Fernanda G. De Felice;Fernanda G. De Felice;Fernanda Tovar-Moll;Jorge Moll;Douglas P. Munoz

  • Structure and functions of the human amyloid precursor protein: the whole is more than the sum of its parts.

    Matthias Gralle;Sérgio T. Ferreira

  • The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease

    Andre F. Batista;Leticia Forny-Germano;Julia R. Clarke;Natalia M. Lyra e Silva

  • Alzheimer's Disease-Like Pathology Induced by amyloid-β Oligomers in Nonhuman Primates

    Leticia Forny-Germano;Natalia M. Lyra E Silva;André F. Batista;Jordano Brito-Moreira

  • Targeting the neurotoxic species in Alzheimer’s disease: inhibitors of Aβ oligomerization

    Fernanda G De Felice;Marcelo N N Vieira;Leonardo M Saraiva;J Daniel Figueroa-Villar

  • Partial Purification and Immunohistochemical Localization of ATP Diphosphohydrolase from Schistosoma mansoni IMMUNOLOGICAL CROSS-REACTIVITIES WITH POTATO APYRASE AND TOXOPLASMA GONDII NUCLEOSIDE TRIPHOSPHATE HYDROLASE

    Eveline G. Vasconcelos;Sérgio T. Ferreira;Técia M. U. de Carvalho;Wanderley de Souza

Frequent Co-Authors

Fernanda G. De Felice
Fernanda G. De Felice Queen's University
William L. Klein
William L. Klein Northwestern University
Douglas P. Munoz
Douglas P. Munoz Queen's University
Sergio Verjovski-Almeida
Sergio Verjovski-Almeida Universidade de São Paulo
Flávia Carvalho Alcantara Gomes
Flávia Carvalho Alcantara Gomes Federal University of Rio de Janeiro
Marco A. M. Prado
Marco A. M. Prado University of Western Ontario
Eric Klann
Eric Klann New York University
Rosalia Mendez-Otero
Rosalia Mendez-Otero Federal University of Rio de Janeiro
Vania F. Prado
Vania F. Prado University of Western Ontario
Fernanda Tovar-Moll
Fernanda Tovar-Moll Federal University of Rio de Janeiro

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