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Chemistry

D-Index
52
Citations
9620
World Ranking
13512
National Ranking
21

Overview

Timothy J. Egan is affiliated with the University of Cape Town in South Africa and has focused their research primarily on medicine and chemistry. Their work spans several subfields including public health, environmental and occupational health, organic chemistry, infectious diseases, computational theory and mathematics, and molecular biology.

The scientist's research topics cover a range of areas such as:

  • Malaria research and control
  • Mosquito-borne diseases and control
  • Computational drug discovery methods
  • HIV/AIDS drug development and treatment
  • Research on leishmaniasis studies
  • Synthesis and biological activity
  • Ferrocene chemistry and applications

Their recent publications include the following papers:

  • Heme Detoxification in the Malaria Parasite: A Target for Antimalarial Drug Development, 2021, Accounts of Chemical Research
  • Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway, 2020, Nature Communications
  • Virtual screening as a tool to discover new β-haematin inhibitors with activity against malaria parasites, 2020, Scientific Reports
  • Naphthylisoquinoline alkaloids, validated as hit multistage antiplasmodial natural products, 2020, International Journal for Parasitology Drugs and Drug Resistance
  • Quinoline Containing Side-chain Antimalarial Analogs: Recent Advances and Therapeutic Application, 2020, Current Topics in Medicinal Chemistry

Frequent publication venues in which they have contributed multiple papers include:

  • Journal of Medicinal Chemistry
  • SSRN Electronic Journal
  • Scientific Reports
  • International Journal for Parasitology Drugs and Drug Resistance
  • Current Topics in Medicinal Chemistry

Frequent co-authors collaborating with Timothy J. Egan encompass:

  • Roxanne Mohunlal
  • Lyn-Marié Birkholtz
  • Kathryn J. Wicht
  • Ana Carolina C. de Sousa
  • Keletso Maepa

The intersection of their fields and topics shows a consistent focus on infectious diseases and computational approaches to discovering antimalarial compounds, with a notable emphasis on medicinal chemistry related to malaria and other mosquito-borne diseases. Their contributions also extend to drug development for HIV/AIDS and research on leishmaniasis, indicating a broad spectrum of work within infectious disease control and treatment.

Best Publications

  • Quinoline anti-malarial drugs inhibit spontaneous formation of β-haematin (malaria pigment)

    Timothy J. Egan;David C. Ross;Paul A. Adams

  • Structure-function relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of beta-hematin formation, and antiplasmodial activity.

    Timothy J. Egan;Roger Hunter;Catherine H. Kaschula;Helder M. Marques

  • Fate of haem iron in the malaria parasite Plasmodium falciparum.

    Timothy J. Egan;Jill M. Combrinck;Joanne Egan;Giovanni R. Hearne

  • Structure-activity relationships in 4-aminoquinoline antiplasmodials. The role of the group at the 7-position

    Catherine H Kaschula;Timothy J Egan;Roger Hunter;Nicoletta Basilico

  • A colorimetric high-throughput β-hematin inhibition screening assay for use in the search for antimalarial compounds

    Kanyile K. Ncokazi;Timothy J. Egan

  • Insights into the Role of Heme in the Mechanism of Action of Antimalarials

    Jill M. Combrinck;Tebogo E. Mabotha;Kanyile K. Ncokazi;Melvin A. Ambele

  • Recent advances in understanding the mechanism of hemozoin (malaria pigment) formation.

    Timothy J. Egan

  • Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds

    Eric M. Guantai;Kanyile Ncokazi;Timothy J. Egan;Jiri Gut

  • Thermodynamic factors controlling the interaction of quinoline antimalarial drugs with ferriprotoporphyrin IX

    Timothy J. Egan;Winile W. Mavuso;David C. Ross;Helder M. Marques

  • The antimalarial ferroquine: role of the metal and intramolecular hydrogen bond in activity and resistance.

    Faustine Dubar;Timothy J Egan;Bruno Pradines;David Kuter

  • Insights into the mechanism of action of ferroquine. Relationship between physicochemical properties and antiplasmodial activity.

    Christophe Biot;Donatella Taramelli;Isabelle Forfar-Bares;Lucien A. Maciejewski

  • The mechanism of beta-hematin formation in acetate solution. Parallels between hemozoin formation and biomineralization processes.

    Timothy J Egan;Winile W Mavuso;Kanyile K Ncokazi

  • Speciation and structure of ferriprotoporphyrin IX in aqueous solution: spectroscopic and diffusion measurements demonstrate dimerization, but not mu-oxo dimer formation

    Katherine A. de Villiers;Catherine H. Kaschula;Timothy J. Egan;Helder M. Marques

  • Haemozoin (β-haematin) biomineralization occurs by self-assembly near the lipid/water interface

    T J Egan;Jack Chen;Katherine A de Villiers;Tebogo E Mabotha

  • Standardization of the Physicochemical Parameters to Assess in Vitro the β-Hematin Inhibitory Activity of Antimalarial Drugs

    Silvia Parapini;Nicoletta Basilico;Erica Pasini;Timothy J Egan

  • Haemozoin: from melatonin pigment to drug target, diagnostic tool, and immune modulator

    Thomas Hänscheid;Timothy J Egan;Martin P Grobusch;Martin P Grobusch

  • The crystal structure of halofantrine–ferriprotoporphyrin IX and the mechanism of action of arylmethanol antimalarials.

    Katherine A. de Villiers;Helder M. Marques;Timothy J. Egan

  • Interactions of quinoline antimalarials with hematin in solution.

    Timothy J. Egan

  • Physico-chemical aspects of hemozoin (malaria pigment) structure and formation

    Timothy J. Egan

  • In vitro antimalarial activity of a series of cationic 2,2'-bipyridyl- and 1,10-phenanthrolineplatinum(II) benzoylthiourea complexes.

    Timothy J. Egan;Klaus R. Koch;Paul L. Swan;Cailean Clarkson

  • Quinoline antimalarials decrease the rate of beta-hematin formation.

    Timothy J. Egan;Kanyile K. Ncokazi

Frequent Co-Authors

Kelly Chibale
Kelly Chibale University of Cape Town
Peter Smith
Peter Smith University of Aberdeen
Sergio Wittlin
Sergio Wittlin Swiss Tropical and Public Health Institute
Donatella Taramelli
Donatella Taramelli University of Milan
David A. Fidock
David A. Fidock Columbia University
Marcel Kaiser
Marcel Kaiser Swiss Tropical and Public Health Institute
Elizabeth A. Winzeler
Elizabeth A. Winzeler University of California, San Diego
Philip J. Rosenthal
Philip J. Rosenthal University of California, San Francisco
Jiri Gut
Jiri Gut University of California, San Francisco
Hans-Peter Beck
Hans-Peter Beck University of Basel

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