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Biology and Biochemistry

D-Index
56
Citations
10088
World Ranking
14538
National Ranking
6106

Overview

Paul D. Roepe is affiliated with Georgetown University in the United States and focuses on research primarily within the field of medicine. Their work spans multiple subfields including public health, environmental and occupational health, epidemiology, oncology, infectious diseases, and molecular biology.

The scientist's research addresses a range of topics with a particular emphasis on malaria and other vector-borne diseases. Key areas of study include:

  • Malaria Research and Control
  • Mosquito-borne diseases and control
  • Trypanosoma species research and implications
  • Drug Transport and Resistance Mechanisms
  • HIV/AIDS drug development and treatment
  • Computational Drug Discovery Methods
  • Research on Leishmaniasis Studies

Paul D. Roepe's recent publications demonstrate a concentration on molecular mechanisms and drug resistance within malaria parasites. Notable papers include:

  • "Artemisinin-Based Drugs Target the Plasmodium falciparum Heme Detoxification Pathway," published in 2021 in Antimicrobial Agents and Chemotherapy
  • "Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance," published in 2022 in PLoS Pathogens
  • "Torin 2 Derivative, NCATS-SM3710, Has Potent Multistage Antimalarial Activity through Inhibition of P. falciparum Phosphatidylinositol 4-Kinase (Pf PI4KIIIβ)," published in 2020 in ACS Pharmacology & Translational Science
  • "Heterologous Expression, Purification, and Functional Analysis of the Plasmodium falciparum Phosphatidylinositol 4-Kinase IIIβ," published in 2020 in Biochemistry
  • "Altered Drug Transport by Plasmodium falciparum Chloroquine Resistance Transporter Isoforms Harboring Mutations Associated with Piperaquine Resistance," published in 2020 in Biochemistry

Their frequent coauthors include:

  • Andreas V. Willems
  • Jennifer L. Small-Saunders
  • Laura M. Hagenah
  • Satish K. Dhingra
  • Jonathan Kim

Paul D. Roepe has contributed multiple publications to leading scientific venues, notably:

  • Biochemistry
  • Antimicrobial Agents and Chemotherapy
  • PLoS Pathogens
  • ACS Pharmacology & Translational Science
  • mBio

Best Publications

  • Mutations in the P. falciparum Digestive Vacuole Transmembrane Protein PfCRT and Evidence for Their Role in Chloroquine Resistance

    David A. Fidock;Takashi Nomura;Angela K. Talley;Roland A. Cooper

  • Novel, Rapid, and Inexpensive Cell-Based Quantification of Antimalarial Drug Efficacy

    Tyler N. Bennett;Michelle Paguio;Bojana Gligorijevic;Clement Seudieu

  • Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum.

    Roland A. Cooper;Michael T. Ferdig;Xin-Zhuan Su;Lyann M. B. Ursos

  • Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America.

    Rajeev K. Mehlotra;Hisashi Fujioka;Paul D. Roepe;Omar Janneh

  • Solution structures of antimalarial drug-heme complexes

    Alison Leed;Kateri DuBay;Lyann M. B. Ursos;Devin Sears

  • Quinoline Drug–Heme Interactions and Implications for Antimalarial Cytostatic versus Cytocidal Activities

    Alexander P Gorka;Angel de Dios;Paul D Roepe

  • Human MDR 1 Protein Overexpression Delays the Apoptotic Cascade in Chinese Hamster Ovary Fibroblasts

    Laura J. Robinson;Wendy K. Roberts;Tao Tao Ling;Dudley Lamming

  • Drug resistance-associated pfCRT mutations confer decreased Plasmodium falciparum digestive vacuolar pH.

    Tyler N Bennett;Andrew D Kosar;Lyann M.B Ursos;Sergey Dzekunov

  • Chloroquine resistance modulated in vitro by expression levels of the Plasmodium falciparum chloroquine resistance transporter.

    Karena L. Waller;Rebecca A. Muhle;Lyann M. Ursos;Paul Horrocks

  • 4-N-, 4-S-, and 4-O-Chloroquine Analogues: Influence of Side Chain Length and Quinolyl Nitrogen pKa on Activity vs Chloroquine Resistant Malaria

    Jayakumar K. Natarajan;John N. Alumasa;Kimberly Yearick;Kekeli A. Ekoue-Kovi

  • Structure and drug resistance of the Plasmodium falciparum transporter PfCRT

    Jonathan Kim;Yong Zi Tan;Kathryn J. Wicht;Satchal K. Erramilli

  • Digestive vacuolar pH of intact intraerythrocytic P. falciparum either sensitive or resistant to chloroquine.

    Sergey M. Dzekunov;Lyann May B. Ursos;Paul D. Roepe

  • Structure and Drug Resistance of the Plasmodium Falciparum Transporter PfCRT

    Jonathan Kim;Yong Zi Tan;Kathryn J. Wicht;Satchal K. Erramilli

  • Characterization of site-directed mutants in the lac permease of Escherichia coli. 2. Glutamate-325 replacements.

    Nancy Carrasco;Irene B. Püttner;Lisa M. Antes;Jonathan A. Lee

  • Chloroquine resistance in the malarial parasite, Plasmodium falciparum.

    Lyann M.B. Ursos;Paul D. Roepe

  • Autophagy is a cell death mechanism in Toxoplasma gondii

    Debasish Ghosh;Julia L. Walton;Paul D. Roepe;Anthony P. Sinai

  • High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations.

    Bryan T. Mott;Richard T. Eastman;Rajarshi Guha;Katy S. Sherlach

  • Fourier transform infrared evidence for Schiff base alteration in the first step of the bacteriorhodopsin photocycle.

    Kenneth J. Rothschild;Paul Roepe;Johan Lugtenburg;Johannes A. Pardoen

  • Synthesis and antimalarial activity of new 4-amino-7-chloroquinolyl amides, sulfonamides, ureas and thioureas.

    Kekeli Ekoue-Kovi;Kimberly Yearick;Daniel P. Iwaniuk;Jayakumar K. Natarajan

  • The P-Glycoprotein Efflux Pump: How Does it Transport Drugs?

    Paul D. Roepe

Frequent Co-Authors

Christian Wolf
Christian Wolf Georgetown University
David A. Fidock
David A. Fidock Columbia University
Manuel Llinás
Manuel Llinás Pennsylvania State University
Craig J. Thomas
Craig J. Thomas National Institutes of Health
Hisashi Fujioka
Hisashi Fujioka Case Western Reserve University
Myles H. Akabas
Myles H. Akabas Albert Einstein College of Medicine
Xin-zhuan Su
Xin-zhuan Su National Institutes of Health
Dennis E. Kyle
Dennis E. Kyle University of Georgia
Thomas E. Wellems
Thomas E. Wellems National Institutes of Health

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