His scientific interests lie mostly in DNA methylation, Genetics, CpG site, Methylation and Molecular biology. His DNA methylation study combines topics in areas such as Cancer research and Transcription factor. His Genetics study frequently draws connections between related disciplines such as Computational biology.
His CpG site research incorporates themes from Bisulfite sequencing and Epigenetics. His Methylation research is multidisciplinary, incorporating elements of Tumor suppressor gene and Epigenetics of physical exercise. His biological study spans a wide range of topics, including DNA methyltransferase, GA-Binding Protein Transcription Factor, Regulation of gene expression, Gene and O-6-methylguanine-DNA methyltransferase.
His primary areas of investigation include Cancer research, DNA methylation, Genetics, Epigenetics and Glioma. His research in Cancer research intersects with topics in Immunology, Cancer and Gene, Mutant. The various areas that Joseph F. Costello examines in his DNA methylation study include Carcinogenesis, Molecular biology and Methylation.
The Methylation study combines topics in areas such as Gene expression and Epigenetics of physical exercise. His work on Genetics deals in particular with Illumina Methylation Assay, Human genome, Differentially methylated regions, Restriction landmark genomic scanning and RNA-Directed DNA Methylation. His work in Epigenomics tackles topics such as Computational biology which are related to areas like Genome.
Joseph F. Costello mainly focuses on Cancer research, Glioma, Mutant, DNA methylation and Somatic hypermutation. The study incorporates disciplines such as Telomere, Methylation and Telomerase reverse transcriptase in addition to Cancer research. His Glioma research is multidisciplinary, relying on both Gene, IDH1 and T-cell receptor.
Joseph F. Costello is interested in Epigenomics, which is a field of DNA methylation. He combines subjects such as Genome-wide association study, Computational biology and Neuroscience with his study of Epigenomics. His Carcinogenesis study integrates concerns from other disciplines, such as Bisulfite sequencing, Regulation of gene expression and Meningioma.
His primary areas of study are Cancer research, Temozolomide, Somatic hypermutation, DNA methylation and Carcinogenesis. His research on Cancer research frequently connects to adjacent areas such as Methylation. His Methylation research integrates issues from Bisulfite sequencing, Regulation of gene expression, Deep sequencing and Somatic evolution in cancer.
His study in DNA methylation is interdisciplinary in nature, drawing from both Andrology and Transcriptome. His study in Epigenomics extends to Carcinogenesis with its themes. His study looks at the relationship between Epigenomics and fields such as Exome sequencing, as well as how they intersect with chemical problems.
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Integrative analysis of 111 reference human epigenomes
Anshul Kundaje;Wouter Meuleman;Wouter Meuleman;Jason Ernst.
Nature (2015)
The clonal and mutational evolution spectrum of primary triple-negative breast cancers
Sohrab P. Shah;Andrew Roth;Rodrigo Goya;Arusha Oloumi.
Nature (2012)
Conserved role of intragenic DNA methylation in regulating alternative promoters
Alika K. Maunakea;Raman P. Nagarajan;Mikhail Bilenky;Tracy J. Ballinger.
Nature (2010)
Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.
Joseph F. Costello;Joseph F. Costello;Michael C. Frühwald;Michael C. Frühwald;Dominic J. Smiraglia;Laura J. Rush.
Nature Genetics (2000)
The NIH Roadmap Epigenomics Mapping Consortium
Bradley E Bernstein;John A Stamatoyannopoulos;Joseph F Costello;Bing Ren.
Nature Biotechnology (2010)
Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma
Brett E. Johnson;Tali Mazor;Chibo Hong;Michael Barnes.
Science (2014)
miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells.
Joachim Silber;Daniel A Lim;Claudia Petritsch;Anders I Persson.
BMC Medicine (2008)
The analgesic efficacy of transversus abdominis plane block after cesarean delivery: a randomized controlled trial.
John G McDonnell;Gerard Curley;John Carney;Aoife Benton.
Anesthesia & Analgesia (2008)
Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications
R Alan Harris;Ting Wang;Cristian Coarfa;Raman P. Nagarajan.
Nature Biotechnology (2010)
A hierarchy of self-renewing tumor-initiating cell types in glioblastoma
Ruihuan Chen;Merry C. Nishimura;Stephanie M. Bumbaca;Samir Kharbanda.
Cancer Cell (2010)
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