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Biology and Biochemistry
Australia
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
80
Citations
18491
World Ranking
4173
National Ranking
101

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Australia Leader Award

Overview

Leann Tilley is a researcher affiliated with the University of Melbourne in Australia. Their work primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a significant body of publications contributing to these areas.

The main subfields of their research include Public Health, Environmental and Occupational Health, Molecular Biology, Immunology, Infectious Diseases, and Epidemiology. This interdisciplinary focus supports investigations into various complex biological and health-related topics.

Tilley's research topics prominently feature Malaria Research and Control, RNA and protein synthesis mechanisms, Mosquito-borne diseases and control, RNA modifications and cancer, HIV/AIDS drug development and treatment, Trypanosoma species research and implications, and Erythrocyte Function and Pathophysiology.

Among recent notable publications are:

  • K13, the Cytostome, and Artemisinin Resistance, 2020, Trends in Parasitology
  • Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy, 2022, Science
  • Role of Plasmodium falciparum Protein GEXP07 in Maurer's Cleft Morphology, Knob Architecture, and P. falciparum EMP1 Trafficking, 2020, mBio
  • Surface area-to-volume ratio, not cellular viscoelasticity, is the major determinant of red blood cell traversal through small channels, 2020, Cellular Microbiology
  • Repurposing the mitotic machinery to drive cellular elongation and chromatin reorganisation in Plasmodium falciparum gametocytes, 2022, Nature Communications

Tilley frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, PLoS Pathogens, Communications Biology, and ACS Infectious Diseases, reflecting a focus on high-impact journals in biology and infectious disease research.

The scientist collaborates regularly with a group of frequent co-authors, including Matthew W. A. Dixon, Stanley C. Xie, Gerald J. Shami, Michael D. W. Griffin, and Con Dogovski, with collaboration counts ranging from 9 to 14 joint works, indicating ongoing partnerships in related research fields.

Best Publications

  • Oxidative stress in malaria parasite-infected erythrocytes: Host-parasite interactions

    Katja Becker;Leann Tilley;Jonathan L. Vennerstrom;David Roberts

  • Quinoline Antimalarials: Mechanisms of Action and Resistance and Prospects for New Agents

    Michael Foley;Leann Tilley

  • Malaria parasite proteins that remodel the host erythrocyte

    Alexander G Maier;Brian Mark Cooke;Alan F Cowman;Leann Tilley;Leann Tilley

  • Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

    Nectarios Klonis;Maria P. Crespo-Ortiz;Iveta Bottova;Nurhidanatasha Abu-Bakar

  • TARGETING THE CELL STRESS RESPONSE OF PLASMODIUM FALCIPARUM TO OVERCOME ARTEMISININ RESISTANCE

    Con Dogovski;Stanley C. Xie;Gaetan Burgio;Jess Bridgford

  • Trafficking and assembly of the cytoadherence complex in Plasmodium falciparum-infected human erythrocytes.

    Mark E. Wickham;Melanie Rug;Stuart A. Ralph;Nectarios Klonis

  • Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarials.

    Paul Loria;Susanne Miller;Michael Foley;Leann Tilley

  • Artemisinin Action and Resistance in Plasmodium falciparum.

    Leann Tilley;Judith Straimer;Nina F. Gnädig;Stuart A. Ralph

  • Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance.

    Patrick G. Bray;Rowena E. Martin;Leann Tilley;Stephen A. Ward

  • Quinoline antimalarials: mechanisms of action and resistance.

    Mick Foley;Leann Tilley

  • Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome.

    Jessica L Bridgford;Stanley C Xie;Simon A Cobbold;Charisse Flerida A Pasaje

  • Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum

    James I MacRae;Matthew Wa Dixon;Megan K Dearnley;Hwa H Chua

  • Structure- and function-based design of Plasmodium-selective proteasome inhibitors

    Hao Li;Hao Li;Anthony J. O’Donoghue;Wouter A. van der Linden;Stanley C. Xie

  • Digestive-vacuole genesis and endocytic processes in the early intraerythrocytic stages of Plasmodium falciparum.

    Nurhidanatasha Abu Bakar;Nectarios Klonis;Eric Hanssen;Cherrine Chan

  • Altered temporal response of malaria parasites determines differential sensitivity to artemisinin.

    Nectarios Klonis;Stanley C. Xie;James M. McCaw;Maria P. Crespo-Ortiz

  • Characterization of the pathway for transport of the cytoadherence-mediating protein, PfEMP1, to the host cell surface in malaria parasite-infected erythrocytes.

    Neline Kriek;Leann Tilley;Paul Horrocks;Robert Pinches

  • Food vacuole‐associated lipid bodies and heterogeneous lipid environments in the malaria parasite, Plasmodium falciparum

    Katherine E. Jackson;Nectarios Klonis;David J. P. Ferguson;Akinola Adisa

  • Plasmodium species: master renovators of their host cells

    Tania F. de Koning-Ward;Matthew W.A. Dixon;Leann Tilley;Paul R. Gilson;Paul R. Gilson

  • Fluorescence photobleaching analysis for the study of cellular dynamics.

    Nectarios Klonis;Melanie Rug;Ian Steward Harper;Mark Wickham

  • A cluster of ring stage-specific genes linked to a locus implicated in cytoadherence in Plasmodium falciparum codes for PEXEL-negative and PEXEL-positive proteins exported into the host cell.

    Tobias Spielmann;Paula L. Hawthorne;Matthew W.A. Dixon;Mandy Hannemann

Frequent Co-Authors

Eric Hanssen
Eric Hanssen University of Melbourne
Michael Foley
Michael Foley La Trobe University
Alan F. Cowman
Alan F. Cowman Walter and Eliza Hall Institute of Medical Research
Robin F. Anders
Robin F. Anders La Trobe University
Paul R. Gilson
Paul R. Gilson Burnet Institute
Brendan S. Crabb
Brendan S. Crabb Monash University
James M. McCaw
James M. McCaw University of Melbourne
Stuart A. Ralph
Stuart A. Ralph University of Melbourne
Bayden R. Wood
Bayden R. Wood Monash University
Malcolm J. McConville
Malcolm J. McConville University of Melbourne

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