World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
45
Citations
5988
World Ranking
2877
National Ranking
81

Overview

Xingzhi Xu is affiliated with Shenzhen University in China and has made extensive contributions to the fields of biochemistry, genetics, and molecular biology. Their research broadly engages with molecular biology and intersects with oncology, cell biology, immunology, and plant science.

The scientist's work is heavily focused on the molecular mechanisms underlying DNA repair and regulation, particularly in relation to cancer and cellular response to DNA damage. Some of the primary research topics they have explored include:

  • DNA Repair Mechanisms
  • Ubiquitin and proteasome pathways
  • RNA modifications and cancer
  • PARP inhibition in cancer therapy
  • Cancer-related Molecular Pathways
  • Microtubule and mitosis dynamics
  • Glycosylation and Glycoproteins Research

Xingzhi Xu has published multiple research articles, notable recent papers include:

  • "HDAC8 cooperates with SMAD3/4 complex to suppress SIRT7 and promote cell survival and migration", 2020, Nucleic Acids Research
  • "Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice", 2020, eLife
  • "Biogenesis of Iron-Sulfur Clusters and Their Role in DNA Metabolism", 2021, Frontiers in Cell and Developmental Biology
  • "PARP1 and CHK1 coordinate PLK1 enzymatic activity during the DNA damage response to promote homologous recombination-mediated repair", 2021, Nucleic Acids Research
  • "TRIM21 suppresses CHK1 activation by preferentially targeting CLASPIN for K63-linked ubiquitination", 2022, Nucleic Acids Research

Their frequent coauthors reflect ongoing collaborations mostly in molecular biology and DNA damage response research. Frequent collaborators include Bin Peng, Wei-Guo Zhu, Jing Li, Zhao-Qi Wang, and Xingxuan Wu.

Regarding publication outlets, Xingzhi Xu's research has appeared predominantly in the following scientific venues:

  • Nucleic Acids Research
  • Genome Instability & Disease
  • Journal of Biological Chemistry
  • Proceedings of the National Academy of Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)

This publication record demonstrates engagement with a range of high-impact journals focusing on molecular biology, DNA repair mechanisms, and cancer-related research. The volume of publications in Nucleic Acids Research and Genome Instability & Disease indicates a consistent thematic focus on nucleic acid biochemistry and genomic stability.

Best Publications

  • A PP4-Phosphatase Complex Dephosphorylates γ-H2AX Generated during DNA Replication

    Dipanjan Chowdhury;Xingzhi Xu;Xueyan Zhong;Fariyal Ahmed

  • Chk2 Activation and Phosphorylation-Dependent Oligomerization

    Xingzhi Xu;Lyuben M. Tsvetkov;David F. Stern

  • Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination.

    Min Gao;Wei Wei;Ming Ming Li;Yong Sheng Wu

  • Protein Phosphatase 6 Interacts with the DNA-Dependent Protein Kinase Catalytic Subunit and Dephosphorylates γ-H2AX

    Pauline Douglas;Jianing Zhong;Ruiqiong Ye;Greg B. G. Moorhead

  • Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

    Xingzhi Xu;Juhie Lee;David F. Stern

  • Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody.

    Lyuben M. Tsvetkov;Xingzhi Xu;Jia Li;David F. Stern

  • Microhomology-mediated end joining: new players join the team

    Hailong Wang;Xingzhi Xu

  • NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways.

    Xingzhi Xu;David F. Stern

  • NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors.

    Xingzhi Xu;David F. Stern

  • Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation

    WooKee Min;Christopher Bruhn;Paulius Grigaravicius;Paulius Grigaravicius;Zhong-Wei Zhou

  • Cloning and characterization of vascular endothelial growth factor (VEGF) from zebrafish, Danio rerio

    Dong Liang;Xingzhi Xu;Alvin J. Chin;Nataraja V. Balasubramaniyan

  • SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair

    Ming Tang;Ming Tang;Zhiming Li;Chaohua Zhang;Xiaopeng Lu

  • MRE11 UFMylation promotes ATM activation.

    Zhifeng Wang;Zhifeng Wang;Yamin Gong;Yamin Gong;Bin Peng;Ruifeng Shi;Ruifeng Shi

  • The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein.

    Xueyan Zhong;Limin Liu;Ailian Zhao;Gerd P. Pfeifer

  • HERC2/USP20 coordinates CHK1 activation by modulating CLASPIN stability.

    Min Zhu;Hongchang Zhao;Ji Liao;Xingzhi Xu

  • Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage

    Bin Peng;Jing Wang;Yuan Hu;Hongli Zhao

  • ALKBH4-dependent demethylation of actin regulates actomyosin dynamics

    Ming-Ming Li;Anja Nilsen;Yue Shi;Yue Shi;Markus Fusser

  • UFMylation: A Unique & Fashionable Modification for Life.

    Ying Wei;Xingzhi Xu

  • Protein phosphatase PP4 is involved in NHEJ-mediated repair of DNA double-strand breaks.

    Jinping Liu;Linli Xu;Jianing Zhong;Ji Liao

  • G9a coordinates with the RPA complex to promote DNA damage repair and cell survival

    Qiaoyan Yang;Qian Zhu;Xiaopeng Lu;Xiaopeng Lu;Yipeng Du

Frequent Co-Authors

Jing Li
Jing Li Rutgers, The State University of New Jersey
Wei-Guo Zhu
Wei-Guo Zhu Shenzhen University
Zhiming Li
Zhiming Li Central South University
David F. Stern
David F. Stern Yale University
Meng-Qiu Dong
Meng-Qiu Dong Tsinghua University
Gerd P. Pfeifer
Gerd P. Pfeifer Van Andel Institute
Zhao-Qi Wang
Zhao-Qi Wang Friedrich Schiller University Jena
Zhou Songyang
Zhou Songyang Sun Yat-sen University
Yun-Gui Yang
Yun-Gui Yang Chinese Academy of Sciences
Susan P. Lees-Miller
Susan P. Lees-Miller University of Calgary

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Molecular Biology can open doors to a variety of rewarding careers across science, healthcare, and technology. However, many students also consider alternative or complementary pathways that align with their interests and ambitions.

For those interested in healthcare communication, a career change for teachers higher pay highlights opportunities in fields like Speech-Language Pathology, where backgrounds in science and communication can lead to increased earning potential.

Scientific skills also transfer well to technical fields. If you are drawn to merging creativity with scientific understanding, consider pursuing an architecture online degree. Architectural studies often intersect with biological concepts in sustainable design.

Analytical minds may thrive in programs like a math degree online, where quantitative and problem-solving skills honed in molecular biology are invaluable.

Creative professionals seeking flexibility and innovation can explore one of the best 2 year graphic design degree online programs to build a diversified skill set.

Each pathway provides unique opportunities for growth—both within and beyond the molecular biosciences.

Best Scientists Citing Xingzhi Xu

Trending Scientists