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Fabrizio d'Adda di Fagagna

Fabrizio d'Adda di Fagagna

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
26507
World Ranking
14138
National Ranking
1109

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Fabrizio d'Adda di Fagagna is affiliated with the University of Cambridge in the United Kingdom. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with significant contributions within the subfields of Molecular Biology, Physiology, Immunology, Aging, and Oncology.

The core topics in their work include:

  • Telomeres, Telomerase, and Senescence
  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • Genetics, Aging, and Longevity in Model Organisms
  • RNA Research and Splicing
  • Interferon and Immune Responses
  • RNA Modifications and Cancer

Fabrizio d'Adda di Fagagna has coauthored extensively with several researchers. Frequent collaborators include:

  • Francesca Rossiello
  • Ubaldo Gioia
  • Fabio Iannelli
  • Matteo Cabrini
  • Claudio Tripodo

Their research has appeared across a variety of scientific publication venues, with notable frequent publications in:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Reviews Molecular Cell Biology
  • Nature Cell Biology

Among their recent scholarly articles are:

  • "Cellular senescence in ageing: from mechanisms to therapeutic opportunities," 2020, Nature Reviews Molecular Cell Biology
  • "Telomere dysfunction in ageing and age-related diseases," 2022, Nature Cell Biology
  • "Guidelines for minimal information on cellular senescence experimentation in vivo," 2024, Cell
  • "SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence," 2023, Nature Cell Biology
  • "Tissue fluidification promotes a cGAS-STING cytosolic DNA response in invasive breast cancer," 2022, Nature Materials

Fabrizio d'Adda di Fagagna is recognized as a member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Cellular senescence: when bad things happen to good cells

    Judith Campisi;Judith Campisi;Fabrizio d'Adda di Fagagna

  • A DNA damage checkpoint response in telomere-initiated senescence

    Fabrizio d'Adda di Fagagna;Philip M. Reaper;Lorena Clay-Farrace;Heike Fiegler

  • Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

    Raffaella Di Micco;Marzia Fumagalli;Angelo Cicalese;Sara Piccinin

  • Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

    Juan C. Acosta;Ana O'Loghlen;Ana Banito;Maria V. Guijarro

  • Cellular senescence in ageing: from mechanisms to therapeutic opportunities

    Raffaella Di Micco;Valery Krizhanovsky;Darren Baker;Fabrizio d’Adda di Fagagna

  • Living on a break: cellular senescence as a DNA-damage response.

    Fabrizio d'Adda di Fagagna

  • Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

    Marzia Fumagalli;Francesca Rossiello;Michela Clerici;Sara Barozzi

  • Site-specific DICER and DROSHA RNA products control the DNA-damage response

    Sofia Francia;Flavia Michelini;Alka Saxena;Dave Tang

  • Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks

    Flavia Michelini;Sethuramasundaram Pitchiaya;Valerio Vitelli;Sheetal Sharma

  • Identification of a DNA Nonhomologous End-Joining Complex in Bacteria

    Geoffrey R. Weller;Boris Kysela;Rajat Roy;Louise M. Tonkin

  • Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer

    Raffaella Di Micco;Gabriele Sulli;Miryana Dobreva;Michalis Liontos

  • Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells

    Fabrizio d'Adda di Fagagna;M.Prakash Hande;Wei-Min Tong;David Roth

  • Functional links between telomeres and proteins of the DNA-damage response

    Fabrizio d'Adda di Fagagna;Soo-Hwang Teo;Stephen P. Jackson

  • Correction: Corrigendum: DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs

    Francesca Rossiello;Julio Aguado;Sara Sepe;Fabio Iannelli

  • Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer

    Gabriele Sulli;Raffaella Di Micco;Fabrizio d'Adda di Fagagna

  • Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage response factors

    Fabio Pessina;Fabio Giavazzi;Yandong Yin;Ubaldo Gioia

  • Oncogene‐induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions

    Anitha Suram;Jessica Kaplunov;Priyanka L Patel;Haihe Ruan

  • Interaction of HIV-1 Tat Protein with Heparin: ROLE OF THE BACKBONE STRUCTURE, SULFATION, AND SIZE

    Marco Rusnati;Daniela Coltrini;Pasqua Oreste;Giorgio Zoppetti

  • BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment

    Giuseppina D’Alessandro;Donna Rose Whelan;Sean Michael Howard;Valerio Vitelli

  • Erratum: Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation (Nature Cell Biology (2012) 14 (355-365))

    Marzia Fumagalli;Francesca Rossiello;Michela Clerici;Sara Barozzi

Frequent Co-Authors

Stephen P. Jackson
Stephen P. Jackson University of Cambridge
Maria Pia Longhese
Maria Pia Longhese University of Milano-Bicocca
Pier Giuseppe Pelicci
Pier Giuseppe Pelicci European Institute of Oncology
M. Prakash Hande
M. Prakash Hande National University of Singapore
Mats Ljungman
Mats Ljungman University of Michigan–Ann Arbor
Luisa Lanfrancone
Luisa Lanfrancone European Institute of Oncology
Judith Campisi
Judith Campisi Buck Institute for Research on Aging
Koichi Kawakami
Koichi Kawakami National Institute of Genetics
Aidan J. Doherty
Aidan J. Doherty University of Sussex

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