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Microbiology

D-Index
45
Citations
6926
World Ranking
5039
National Ranking
1946

Overview

Ian A. Critchley is affiliated with Spero Therapeutics in the United States and has a research focus primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Molecular Medicine, Epidemiology, Pharmacology, Applied Microbiology and Biotechnology, and Infectious Diseases.

The scientist's main research topics cover:

  • Antibiotic Resistance in Bacteria
  • Antibiotics Pharmacokinetics and Efficacy
  • Urinary Tract Infections Management
  • Antibiotic Use and Resistance
  • Mycobacterium research and diagnosis
  • Tuberculosis Research and Epidemiology
  • Bacterial Identification and Susceptibility Testing

Ian A. Critchley has contributed to numerous publications, including the following notable recent papers:

  • Oral Tebipenem Pivoxil Hydrobromide in Complicated Urinary Tract Infection, 2022, New England Journal of Medicine
  • Resistance among urinary tract pathogens collected in Europe during 2018, 2020, Journal of Global Antimicrobial Resistance
  • In Vitro and In Vivo Characterization of Tebipenem, an Oral Carbapenem, 2020, Antimicrobial Agents and Chemotherapy
  • In Vitro Resistance against DNA Gyrase Inhibitor SPR719 in Mycobacterium avium and Mycobacterium abscessus, 2022, Microbiology Spectrum
  • Evaluation of Tebipenem Hydrolysis by β-Lactamases Prevalent in Complicated Urinary Tract Infections, 2022, Antimicrobial Agents and Chemotherapy

Frequent co-authors collaborating with Ian A. Critchley include:

  • Nicole Cotroneo
  • Rodrigo E. Mendes
  • Mariana Castanheira
  • Michael J. Pucci
  • S J Ryan Arends

Their research is published in a variety of venues, with a notable number of works appearing in:

  • Open Forum Infectious Diseases
  • Antimicrobial Agents and Chemotherapy
  • Microbiology Spectrum
  • New England Journal of Medicine
  • Journal of Global Antimicrobial Resistance

Best Publications

  • Integrated analysis of CANVAS 1 and 2: phase 3, multicenter, randomized, double-blind studies to evaluate the safety and efficacy of ceftaroline versus vancomycin plus aztreonam in complicated skin and skin-structure infection.

    G. Ralph Corey;Mark Wilcox;George H. Talbot;H. David Friedland

  • Regional Trends in Antimicrobial Resistance among Clinical Isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the United States: Results from the TRUST Surveillance Program, 1999–2000

    Clyde Thornsberry;Daniel F. Sahm;Laurie J. Kelly;Ian A. Critchley

  • Integrated Analysis of FOCUS 1 and FOCUS 2: Randomized, Doubled-Blinded, Multicenter Phase 3 Trials of the Efficacy and Safety of Ceftaroline Fosamil versus Ceftriaxone in Patients with Community-Acquired Pneumonia

    Thomas M. File;Thomas M. File;Donald E. Low;Donald E. Low;Paul B. Eckburg;George H. Talbot

  • Factors Associated with Relative Rates of Antimicrobial Resistance among Streptococcus pneumoniae in the United States: Results from the TRUST Surveillance Program (1998–2002)

    James A. Karlowsky;Clyde Thornsberry;Mark E. Jones;Alan T. Evangelista

  • FOCUS 1: A randomized, double-blinded, multicentre, phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia

    Thomas M. File;Donald E. Low;Paul B. Eckburg;George H. Talbot

  • FOCUS 2: a randomized, double-blinded, multicentre, Phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia

    Donald E. Low;Thomas M. File;Paul B. Eckburg;George H. Talbot

  • The effects of adherence to silicone surfaces on antibiotic susceptibility in Staphylococcus aureus

    Ian Williams;W. Alfred Venables;David Lloyd;Frank Paul

  • Need for Annual Surveillance of Antimicrobial Resistance in Streptococcus pneumoniae in the United States: 2-Year Longitudinal Analysis

    Daniel F. Sahm;James A. Karlowsky;Laurie J. Kelly;Ian A. Critchley

  • The burden of antimicrobial resistance among urinary tract isolates of Escherichia coli in the United States in 2017.

    Ian A. Critchley;Nicole Cotroneo;Michael J. Pucci;Rodrigo Mendes

  • Activity of daptomycin against susceptible and multidrug-resistant Gram-positive pathogens collected in the SECURE study (Europe) during 2000–2001

    Ian A Critchley;Deborah C Draghi;Daniel F Sahm;Clyde Thornsberry

  • Isolation and Partial Characterization of an Adhesin from Candida albicans

    Unknown

  • Effect of antibiotics on non-growing planktonic cells and biofilms of Escherichia coli.

    Unknown

  • Ceftaroline fosamil: a novel broad-spectrum cephalosporin with expanded anti-Gram-positive activity

    Donald Biek;Ian A Critchley;Todd A Riccobene;Dirk A Thye

  • Susceptibility to fluoroquinolones among commonly isolated Gram-negative bacilli in 2000: TRUST and TSN data for the United States

    James A. Karlowsky;Laurie J. Kelly;Clyde Thornsberry;Mark E. Jones

  • Evaluation of Current Activities of Fluoroquinolones against Gram-Negative Bacilli Using Centralized In Vitro Testing and Electronic Surveillance

    Daniel F. Sahm;Ian A. Critchley;Laurie J. Kelly;James A. Karlowsky

  • Aminoacyl-tRNA synthetases: essential and still promising targets for new anti-infective agents

    Urs A Ochsner;Xicheng Sun;Thale Jarvis;Ian Critchley

  • Prevalence of antimicrobial resistance among urinary tract pathogens isolated from female outpatients across the US in 1999

    James A Karlowsky;Mark E Jones;Clyde Thornsberry;Ian Critchley

  • Activity of chequerboard combinations of ceftaroline and NXL104 versus β-lactamase-producing Enterobacteriaceae

    Shazad Mushtaq;Marina Warner;G. Williams;I. Critchley

  • Avibactam Pharmacokinetic/Pharmacodynamic Targets.

    Wright W. Nichols;Paul Newell;Ian A. Critchley;Todd Riccobene

  • Baseline Study To Determine In Vitro Activities of Daptomycin against Gram-Positive Pathogens Isolated in the United States in 2000-2001

    Ian A. Critchley;Renée S. Blosser-Middleton;Mark E. Jones;Clyde Thornsberry

  • Pharmacodynamics of β-Lactamase Inhibition by NXL104 in Combination with Ceftaroline: Examining Organisms with Multiple Types of β-Lactamases

    Arnold Louie;Mariana Castanheira;Weiguo Liu;Caroline Grasso

  • Activity of Ceftaroline against Recent Emerging Serotypes of Streptococcus pneumoniae in the United States

    Michael R. Jacobs;Caryn E. Good;Anne R. Windau;Saralee Bajaksouzian

  • Inhibitory effect of REP3123 on toxin and spore formation in Clostridium difficile, and in vivo efficacy in a hamster gastrointestinal infection model

    Urs A Ochsner;Stacie J Bell;Ann L O'Leary;Teresa Hoang

  • In vitro activity of levofloxacin against contemporary clinical isolates of Legionella pneumophila, Mycoplasma pneumoniae and Chlamydia pneumoniae from North America and Europe

    I.A. Critchley;M.E. Jones;P.D. Heinze;D. Hubbard

  • Role of glycosides as epithelial cell receptors for Candida albicans.

    Unknown

Frequent Co-Authors

Mark E. Jones
Mark E. Jones Basilea Pharmaceutica (Switzerland)
James A. Karlowsky
James A. Karlowsky University of Manitoba
Clyde Thornsberry
Clyde Thornsberry Centers for Disease Control and Prevention
Ronald N. Jones
Ronald N. Jones JMI Laboratories
Helio S. Sader
Helio S. Sader JMI Laboratories
Nebojsa Janjic
Nebojsa Janjic Astellas Pharma (Japan)
Rodrigo E. Mendes
Rodrigo E. Mendes JMI Laboratories
Urs A. Ochsner
Urs A. Ochsner University of Colorado Anschutz Medical Campus
Michael R. Jacobs
Michael R. Jacobs University Hospitals of Cleveland

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