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David P. Nicolau

David P. Nicolau

D-Index & Metrics

Microbiology

D-Index
85
Citations
28418
World Ranking
870
National Ranking
402

Medicine

D-Index
86
Citations
29376
World Ranking
14058
National Ranking
7130

Overview

David P. Nicolau is affiliated with Hartford Hospital in the United States. Their research primarily focuses on the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions to Pharmacology, Molecular Medicine, Epidemiology, Molecular Biology, and Pediatrics, Perinatology and Child Health.

The main topics of Nicolau's work include Antibiotics Pharmacokinetics and Efficacy, Antibiotic Resistance in Bacteria, Bacterial Biofilms and Quorum Sensing, Pneumonia and Respiratory Infections, Pharmacological Effects and Toxicity Studies, Antibiotic Use and Resistance, and Pharmaceutical Studies and Practices.

The scientist has published extensively in several venues, with the most frequent publication outlets being:

  • Journal of Antimicrobial Chemotherapy
  • Open Forum Infectious Diseases
  • Journal of Medicinal Chemistry
  • ACS Infectious Diseases
  • Antimicrobial Agents and Chemotherapy

Recent papers authored or co-authored by David P. Nicolau include:

  • A Modular Synthetic Route Involving N-Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3-Substituted Halogenated Phenazine Antibacterial Agents, 2021, Journal of Medicinal Chemistry
  • Transcript Profiling of Nitroxoline-Treated Biofilms Shows Rapid Up-regulation of Iron Acquisition Gene Clusters, 2022, ACS Infectious Diseases
  • Assessing the in vivo efficacy of rational antibiotics and combinations against difficult-to-treat Pseudomonas aeruginosa producing GES β-lactamases, 2023, Journal of Antimicrobial Chemotherapy
  • Pharmacokinetics and soft-tissue distribution of tebipenem pivoxil hydrobromide using microdialysis: a study in healthy subjects and patients with diabetic foot infections, 2022, Journal of Antimicrobial Chemotherapy
  • Defining optimal sulbactam regimens for treatment of Acinetobacter baumannii pneumonia and impact of blaOXA-23 on efficacy, 2024, Journal of Antimicrobial Chemotherapy

Frequent collaborators in their work include:

  • David P. Nicolau
  • Joseph L. Kuti
  • Christian M. Gill
  • Aliaa Fouad
  • Yuwei Shen

Best Publications

  • Experience with a once-daily aminoglycoside program administered to 2,184 adult patients.

    D P Nicolau;C D Freeman;P P Belliveau;C H Nightingale

  • Clinical Pharmacodynamics of Meropenem in Patients with Lower Respiratory Tract Infections

    Chonghua Li;Xiaoli Du;Joseph L. Kuti;David P. Nicolau

  • Once-daily dosing of aminoglycosides: review and recommendations for clinical practice.

    Collin D. Freeman;David P. Nicolau;Paul P. Belliveau;Charles H. Nightingale

  • Pharmacodynamic comparisons of levofloxacin, ciprofloxacin, and ampicillin against Streptococcus pneumoniae in an in vitro model of infection

    Melinda K. Lacy;Wen Lu;Xiaowei Xu;Pamela R. Tessier

  • The pharmacodynamics of aminoglycosides

    Melinda K. Lacy;David P. Nicolau;Charles H. Nightingale;Richard Quintiliani

  • Use of Monte Carlo simulation to design an optimized pharmacodynamic dosing strategy for meropenem.

    Joseph L. Kuti;Prachi K. Dandekar;Charles H. Nightingale;David P. Nicolau

  • Pharmacokinetic and Pharmacodynamic Properties of Meropenem

    David P. Nicolau

  • Carbapenems: a potent class of antibiotics.

    David P Nicolau

  • Carbapenemase-producing Pseudomonas aeruginosa –an emerging challenge

    Unknown

  • Double-Carbapenem Therapy for Carbapenemase-Producing Klebsiella pneumoniae

    Catharine C. Bulik;David P. Nicolau

  • Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

    Massimo Sartelli;Dieter G. Weber;Etienne Ruppé;Matteo Bassetti

  • Population pharmacokinetic analysis and dosing regimen optimization of meropenem in adult patients

    Chonghua Li;Joseph L. Kuti;Charles H. Nightingale;David P. Nicolau

  • Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships.

    Unknown

  • Adherence to Highly Active Antiretroviral Therapy Predicts Virologic Outcome at an Inner-City Human Immunodeficiency Virus Clinic

    JoCarol McNabb;Jack W. Ross;Kenneth Abriola;Christina Turley

  • Continuous versus intermittent administration of ceftazidime in intensive care unit patients with nosocomial pneumonia.

    David P Nicolau;JoCarol McNabb;Melinda K Lacy;Richard Quintiliani

  • Relationship between Fluoroquinolone Use and Changes in Susceptibility to Fluoroquinolones of Selected Pathogens in 10 United States Teaching Hospitals, 1991–2000

    Marcus J. Zervos;Marcus J. Zervos;Ellie Hershberger;Ellie Hershberger;David P. Nicolau;David J. Ritchie;David J. Ritchie

  • Antimicrobial resistance: impact on clinical and economic outcomes and the need for new antimicrobials.

    Abrar K Thabit;Jared L Crandon;David P Nicolau

  • Preventive and therapeutic strategies in critically ill patients with highly resistant bacteria

    Matteo Bassetti;Jan J. De Waele;Philippe Eggimann;Josè Garnacho-Montero

  • Impact of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species on clinical outcomes and hospital costs: a matched cohort study.

    Su Young Lee;Srividya Kotapati;Joseph L Kuti;Charles H Nightingale

  • Randomized, Open-Label, Comparative Study of Piperacillin-Tazobactam Administered by Continuous Infusion versus Intermittent Infusion for Treatment of Hospitalized Patients with Complicated Intra-Abdominal Infection

    William K. Lau;David Mercer;Kamal M. Itani;David P. Nicolau

  • The Current State of Multidrug-Resistant Gram-Negative Bacilli in North America

    Anthony M Nicasio;Joseph L Kuti;David P Nicolau

  • Clinical efficacy and pharmacoeconomics of a continuous-infusion piperacillin-tazobactam program in a large community teaching hospital.

    Edward M. Grant;Joseph L. Kuti;David P. Nicolau;Charles Nightingale

Frequent Co-Authors

Joseph L. Kuti
Joseph L. Kuti Hartford Hospital
Charles H. Nightingale
Charles H. Nightingale University of Connecticut
Richard Quintiliani
Richard Quintiliani Hartford Hospital
Jason A. Roberts
Jason A. Roberts University of Queensland
Matteo Bassetti
Matteo Bassetti University of Genoa
Cesar A. Arias
Cesar A. Arias The University of Texas Health Science Center at Houston
Antoni Torres
Antoni Torres University of Barcelona
Stephen G. Jenkins
Stephen G. Jenkins Cornell University
Michael J. Satlin
Michael J. Satlin Cornell University
Helen Giamarellou
Helen Giamarellou National and Kapodistrian University of Athens

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