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D-Index
60
Citations
11723
World Ranking
3173
National Ranking
389

Overview

Aidan J. Doherty is a researcher affiliated with the University of Sussex in the United Kingdom. Their work primarily focuses on Biochemistry, Genetics, and Molecular Biology, contributing to 32 publications in this field. Within this broad area, Doherty's research is especially concentrated on subfields such as Molecular Biology, Genetics, Cell Biology, Infectious Diseases, and Epidemiology.

The central topics of Doherty's research include:

  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • DNA and Nucleic Acid Chemistry
  • Bacterial Genetics and Biotechnology
  • RNA and protein synthesis mechanisms
  • Genomics and Chromatin Dynamics
  • Microtubule and mitosis dynamics

Doherty has published in several reputable scientific venues, with multiple papers appearing in:

  • Nature Communications (3 publications)
  • Nucleic Acids Research (2 publications)
  • Human Molecular Genetics
  • Science Advances
  • Nature

Selected recent papers by Doherty include:

  • "PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts," 2020, Nature Communications
  • "Mitochondrial genetic variation is enriched in G-quadruplex regions that stall DNA synthesis in vitro," 2020, Human Molecular Genetics
  • "Repriming DNA synthesis: an intrinsic restart pathway that maintains efficient genome replication," 2021, Nucleic Acids Research
  • "PLK1 regulates the PrimPol damage tolerance pathway during the cell cycle," 2021, Science Advances
  • "Molecular basis for the initiation of DNA primer synthesis," 2022, Nature

Doherty frequently collaborates with a core group of coauthors, which includes:

  • Kateřina Zábrady
  • Lewis J. Bainbridge
  • Arthur W.H. Li
  • Peter Kolesár
  • Matej Zábrady

Their work spans molecular insights into DNA replication processes, DNA damage tolerance pathways, and genetic variations affecting mitochondrial DNA. Doherty's publications often explore mechanisms underlying genome replication fidelity and repair processes, contributing to expanding understanding within molecular biology and genetics.

Best Publications

  • A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

    Enriqueta Riballo;Martin Kühne;Nicole Rief;Aidan Doherty

  • EMSY Links the BRCA2 Pathway to Sporadic Breast and Ovarian Cancer

    Luke Hughes-Davies;David Huntsman;Margarida Ruas;Francois Fuks

  • The Helix-Hairpin-Helix DNA-Binding Motif: A Structural Basis for Non-Sequence-Specific Recognition of DNA

    Aidan J. Doherty;Louise C. Serpell;Christopher P. Ponting

  • Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient

    Riballo E;Critchlow Se;Teo Sh;Doherty Aj

  • Identification of a DNA Nonhomologous End-Joining Complex in Bacteria

    Geoffrey R. Weller;Boris Kysela;Rajat Roy;Louise M. Tonkin

  • Crystal Structure of an ATP-Dependent DNA Ligase from Bacteriophage T7

    Hosahalli S. Subramanya;Aidan J. Doherty;Stephen R. Ashford;Dale B. Wigley

  • Mycobacterial Ku and Ligase Proteins Constitute a Two-Component NHEJ Repair Machine

    Marina Della;Phillip L. Palmbos;Hui Min Tseng;Louise M. Tonkin;Louise M. Tonkin

  • PrimPol Bypasses UV Photoproducts during Eukaryotic Chromosomal DNA Replication

    Julie Bianchi;Sean G. Rudd;Stanislaw K. Jozwiakowski;Laura J. Bailey

  • X-Ray Crystallography Reveals a Large Conformational Change during Guanyl Transfer by mRNA Capping Enzymes

    Kjell Håkansson;Aidan J. Doherty;Stewart Shuman;Dale B. Wigley

  • A heterotrimeric PCNA in the hyperthermophilic archaeon Sulfolobus solfataricus.

    Isabelle Dionne;Ravi K Nookala;Stephen P Jackson;Aidan J Doherty

  • Crystal Structure of Human 53BP1 Brct Domains Bound to P53 Tumour Suppressor

    Dean J. Derbyshire;Balaku P. Basu;Louise C. Serpell;Woo S. Joo

  • Making ends meet: repairing breaks in bacterial DNA by non-homologous end-joining.

    Richard Bowater;Aidan J Doherty

  • Structural and mechanistic conservation in DNA ligases

    Aidan J. Doherty;Se Won Suh

  • Nonhomologous End-Joining in Bacteria: A Microbial Perspective

    Robert S Pitcher;Nigel C Brissett;Aidan J Doherty

  • Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA.

    Kuniyoshi Iwabuchi;Balaka Piku Basu;Boris Kysela;Takayuki Kurihara

  • PrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells

    Davide Schiavone;Stanislaw K. Jozwiakowski;Marina Romanello;Guillaume Guilbaud

  • The GAR Motif of 53BP1 is Arginine Methylated by PRMT1 and is Necessary for 53BP1 DNA Binding Activity

    François-Michel Boisvert;Alexandre Rhie;Stéphane Richard;Aidan J. Doherty

  • Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: the impact of two linked polymorphisms

    Pierre-Marie Girard;Boris Kysela;Christine J. Härer;Aidan J. Doherty

  • Identification of bacterial homologues of the Ku DNA repair proteins.

    Aidan J. Doherty;Stephen P. Jackson;Geoffrey R. Weller

  • Role of DNA Repair by Nonhomologous-End Joining in Bacillus subtilis Spore Resistance to Extreme Dryness, Mono- and Polychromatic UV, and Ionizing Radiation

    Ralf Moeller;Ralf Moeller;Erko Stackebrandt;Günther Reitz;Thomas Berger

Frequent Co-Authors

Penny A. Jeggo
Penny A. Jeggo University of Sussex
Stephen P. Jackson
Stephen P. Jackson University of Cambridge
Tony Kouzarides
Tony Kouzarides University of Cambridge
Luis Blanco
Luis Blanco Spanish National Research Council
Dmitry B. Veprintsev
Dmitry B. Veprintsev University of Nottingham
Louise C. Serpell
Louise C. Serpell University of Sussex
Julian E. Sale
Julian E. Sale MRC Laboratory of Molecular Biology
Alan R. Lehmann
Alan R. Lehmann University of Sussex
Wayne L. Nicholson
Wayne L. Nicholson University of Florida
Nick J. Proudfoot
Nick J. Proudfoot University of Oxford

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