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Biology and Biochemistry

D-Index
52
Citations
8846
World Ranking
16774
National Ranking
591

Overview

George Harauz is affiliated with the University of Guelph in Canada and has contributed to multiple areas within medicine, biochemistry, genetics, molecular biology, and neuroscience. Their research has focused particularly on mechanisms related to neurological disorders and cellular processes at the molecular level.

Their recent scholarly work includes studies published in various peer-reviewed journals. Among these are:

  • α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology (2021, Cell Reports)
  • Effect of Cholesterol and Myelin Basic Protein (MBP) Content on Lipid Monolayers Mimicking the Cytoplasmic Membrane of Myelin (2020, Cells)
  • Partial magic angle spinning NMR 1H, 13C, 15N resonance assignments of the flexible regions of a monomeric alpha-synuclein: conformation of C-terminus in the lipid-bound and amyloid fibril states (2021, Biomolecular NMR Assignments)
  • Niche-dependent inhibition of neural stem cell proliferation and oligodendrogenesis is mediated by the presence of myelin basic protein (2021, Stem Cells)
  • Shaping membrane interfaces in lipid vesicles mimicking the cytoplasmic leaflet of myelin through variation of cholesterol and myelin basic protein contents (2023, Biochimica et Biophysica Acta (BBA) - Biomembranes)

Their research addresses several key topics including:

  • Parkinson's Disease Mechanisms and Treatments
  • Lipid Membrane Structure and Behavior
  • Neurogenesis and Neuroplasticity Mechanisms
  • Neurological Disorders and Treatments
  • Cellular Transport and Secretion
  • RNA Interference and Gene Delivery
  • Alzheimer's Disease Research and Treatments

Harauz's work spans important subfields such as neurology, molecular biology, developmental neuroscience, cellular and molecular neuroscience, and cell biology. The scope of their research is multidisciplinary within life sciences and neuroscience, underlining contributions to both fundamental biology and disease-related investigations.

Frequent co-authors collaborating with Harauz include Vladimir V. Bamm, Carla Coackley, Scott D. Ryan, Jennica Träger, and Dariush Hinderberger. These collaborations reflect a network of interdisciplinary work focused on molecular and cellular aspects of neuroscience and biochemistry.

Their publications have appeared regularly in established journals such as Cell Reports, Cells, Biomolecular NMR Assignments, Stem Cells, and Biochimica et Biophysica Acta (BBA) - Biomembranes.

Best Publications

  • A new generation of the IMAGIC image processing system.

    Marin van Heel;George Harauz;Elena V. Orlova;Ralf Schmidt

  • Participation of a cyanobacterial S layer in fine-grain mineral formation.

    S Schultze-Lam;G Harauz;T J Beveridge

  • Myelin basic protein - diverse conformational states of an intrinsically unstructured protein and its roles in myelin assembly and multiple sclerosis

    George Harauz;Noboru Ishiyama;Christopher M.D Hill;Ian R Bates;Ian R Bates

  • Structural Polymorphism and Multifunctionality of Myelin Basic Protein

    George Harauz;Vladimir Ladizhansky;Joan M. Boggs

  • Deimination of myelin basic protein. 1. Effect of deimination of arginyl residues of myelin basic protein on its structure and susceptibility to digestion by cathepsin D.

    Laura B. Pritzker;Shashikant Joshi;Jessica J. Gowan;George Harauz

  • Myelin management by the 18.5-kDa and 21.5-kDa classic myelin basic protein isoforms.

    George Harauz;Joan M. Boggs

  • A tale of two citrullines--structural and functional aspects of myelin basic protein deimination in health and disease.

    George Harauz;Abdiwahab A. Musse

  • Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein

    Tammy Ryan;Vladimir V. Bamm;Morgan G. Stykel;Carla L. Coackley

  • Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system

    Abdiwahab A. Musse;Zhen Li;Cameron A. Ackerley;Dorothee Bienzle

  • Deimination of membrane-bound myelin basic protein in multiple sclerosis exposes an immunodominant epitope

    Abdiwahab A. Musse;Joan M. Boggs;George Harauz

  • White Matter Rafting––Membrane Microdomains in Myelin

    Lillian S. DeBruin;Lillian S. DeBruin;George Harauz

  • Translocation of group 1 capsular polysaccharide in Escherichia coli serotype K30. Structural and functional analysis of the outer membrane lipoprotein Wza.

    Jutta Nesper;Chris M.D. Hill;Anne Paiment;George Harauz

  • Deimination of myelin basic protein. 2. Effect of methylation of MBP on its deimination by peptidylarginine deiminase.

    Laura B. Pritzker;Shashikant Joshi;George Harauz;Mario A. Moscarello

  • Three-dimensional structure of myelin basic protein. II. Molecular modeling and considerations of predicted structures in multiple sclerosis.

    Ross A. Ridsdale;Daniel R. Beniac;Thomas A. Tompkins;Mario A. Moscarello

  • Nucleosome reconstruction via phosphorus mapping

    George Harauz;F. P. Ottensmeyer;F. P. Ottensmeyer

  • Three-dimensional Structure of Myelin Basic Protein I. RECONSTRUCTION VIA ANGULAR RECONSTITUTION OF RANDOMLY ORIENTED SINGLE PARTICLES

    Daniel R. Beniac;Maria D. Luckevich;Gregory J. Czarnota;Thomas A. Tompkins

  • Cryoelectron Microscopy of Protein–Lipid Complexes of Human Myelin Basic Protein Charge Isomers Differing in Degree of Citrullination

    Beniac Dr;Wood Dd;Palaniyar N;Ottensmeyer Fp

  • MyelStones: the executive roles of myelin basic protein in myelin assembly and destabilization in multiple sclerosis.

    Kenrick A. Vassall;Vladimir V. Bamm;George Harauz

  • Binding of the proline-rich segment of myelin basic protein to SH3 domains: spectroscopic, microarray, and modeling studies of ligand conformation and effects of posttranslational modifications.

    Eugenia Polverini;Godha Rangaraj;David S. Libich;Joan M. Boggs

  • Interaction of the 18.5-kD isoform of myelin basic protein with Ca2+-calmodulin: Effects of deimination assessed by intrinsic Trp fluorescence spectroscopy, dynamic light scattering, and circular dichroism

    David S. Libich;Christopher M.D. Hill;Ian R. Bates;F. Ross Hallett

Frequent Co-Authors

Joan M. Boggs
Joan M. Boggs University of Toronto
Mario A. Moscarello
Mario A. Moscarello University of Toronto
Mahmoud W. Yaish
Mahmoud W. Yaish Sultan Qaboos University
K. W. Michael Siu
K. W. Michael Siu University of Windsor
Leonid S. Brown
Leonid S. Brown University of Guelph
Lawrence I. Rothblum
Lawrence I. Rothblum University of Oklahoma
Chris Whitfield
Chris Whitfield University of Guelph
Fred Possmayer
Fred Possmayer University of Western Ontario
Anthony T. Campagnoni
Anthony T. Campagnoni University of California, Los Angeles
Stuart A. Lipton
Stuart A. Lipton Scripps Research Institute

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