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Leonid S. Brown

Leonid S. Brown

D-Index & Metrics

Chemistry

D-Index
60
Citations
10719
World Ranking
9880
National Ranking
262

Overview

Leonid S. Brown is affiliated with the University of Guelph in Canada. Their research primarily spans the fields of Neuroscience and Biochemistry, Genetics and Molecular Biology, with significant contributions in subfields such as Cellular and Molecular Neuroscience, Molecular Biology, Spectroscopy, Biomedical Engineering, and Cognitive Neuroscience.

The main topics explored in Brown's work include Photoreceptor and Optogenetics Research, Neuroscience and Neuropharmacology Research, Bioluminescence and Chemiluminescence Research, Molecular Communication and Nanonetworks, Neural Dynamics and Brain Function, Advanced NMR Techniques and Applications, and Plant and Biological Electrophysiology Studies.

Frequent publication venues for Brown's research include bioRxiv (Cold Spring Harbor Laboratory), Biophysical Journal, The Journal of Physical Chemistry B, mBio, and Biochimica et Biophysica Acta (BBA) - Biomembranes.

They have collaborated extensively with co-authors such as Elena G. Govorunova, Oleg A. Sineshchekov, John L. Spudich, Hai Li, and Ana-Nicoleta Bondar.

The following are selected recent publications from Brown's research portfolio:

  • Kalium channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition, 2022, Nature Neuroscience
  • RubyACRs, nonalgal anion channelrhodopsins with highly red-shifted absorption, 2020, Proceedings of the National Academy of Sciences
  • Mechanism of Inward Proton Transport in an Antarctic Microbial Rhodopsin, 2020, The Journal of Physical Chemistry B
  • The crystal structures of a chloride-pumping microbial rhodopsin and its proton-pumping mutant illuminate proton transfer determinants, 2020, Journal of Biological Chemistry
  • Cation and Anion Channelrhodopsins: Sequence Motifs and Taxonomic Distribution, 2021, mBio

Best Publications

  • Microbial and animal rhodopsins: structures, functions, and molecular mechanisms.

    Oliver P. Ernst;David Thomas Lodowski;Marcus Elstner;Peter Hegemann

  • Coherent control of retinal isomerization in bacteriorhodopsin.

    Valentyn I. Prokhorenko;Andrea M. Nagy;Stephen A. Waschuk;Leonid S. Brown

  • Glutamic Acid 204 is the Terminal Proton Release Group at the Extracellular Surface of Bacteriorhodopsin

    Leonid S. Brown;Jun Sasaki;Hideki Kandori;Akio Maeda

  • Protein conformational changes in the bacteriorhodopsin photocycle.

    Sriram Subramaniam;Martin Lindahl;Per Bullough;A.R Faruqi

  • Conversion of bacteriorhodopsin into a chloride ion pump.

    Jun Sasaki;Leonid S. Brown;Young-Shin Chon;Hideki Kandori

  • Proton transfers in the photochemical reaction cycle of proteorhodopsin.

    Andrei K. Dioumaev;Leonid S. Brown;Jennifer Shih;Elena N. Spudich

  • Solid-state NMR spectroscopy structure determination of a lipid-embedded heptahelical membrane protein.

    Shenlin Wang;Rachel A. Munro;Lichi Shi;Lichi Shi;Izuru Kawamura;Izuru Kawamura

  • Proton binding within a membrane protein by a protonated water cluster

    Florian Garczarek;Leonid S. Brown;Janos K. Lanyi;Klaus Gerwert

  • Leptosphaeria rhodopsin: Bacteriorhodopsin-like proton pump from a eukaryote

    Stephen A. Waschuk;Arandi G. Bezerra;Lichi Shi;Leonid S. Brown

  • Existence of a Proton Transfer Chain in Bacteriorhodopsin: Participation of Glu-194 in the Release of Protons to the Extracellular Surface†

    Andrei K. Dioumaev;Hans Thomas Richter;Leonid S. Brown;Michikazu Tanio

  • Crystallographic structures of the M and N intermediates of bacteriorhodopsin: assembly of a hydrogen-bonded chain of water molecules between Asp-96 and the retinal Schiff base.

    Brigitte Schobert;Leonid S. Brown;Janos K. Lanyi

  • A linkage of the pKa's of asp-85 and glu-204 forms part of the reprotonation switch of bacteriorhodopsin.

    Hans-Thomas Richter;Leonid S. Brown;Richard Needleman;Janos K. Lanyi

  • Three-dimensional solid-state NMR study of a seven-helical integral membrane proton pump--structural insights.

    Lichi Shi;Mumdooh A.M. Ahmed;Wurong Zhang;Gregg Whited

  • Energy coupling in an ion pump: The reprotonation switch of bacteriorhodopsin

    Mikio Kataoka;Hironari Kamikubo;Fumio Tokunagga;Leonid S. Brown

  • Conformation of a Seven-Helical Transmembrane Photosensor in the Lipid Environment†

    Lichi Shi;Izuru Kawamura;Kwang Hwan Jung;Leonid S. Brown

  • Transient channel-opening in bacteriorhodopsin: an EPR study.

    Thorgeir E. Thorgeirsson;Wenzhong Xiao;Leonid S. Brown;Richard Needleman

  • Characterization of the photochemical reaction cycle of proteorhodopsin

    György Váró;Leonid S. Brown;Melinda Lakatos;Janos K. Lanyi

  • Light-driven chloride ion transport by halorhodopsin from Natronobacterium pharaonis. 1. The photochemical cycle.

    Gyorgy Varo;Leonid S. Brown;Jun Sasaki;Hideki Kandori

  • The Photocycle and Proton Translocation Pathway in a Cyanobacterial Ion-Pumping Rhodopsin

    Mylene R.M. Miranda;Ah Rheum Choi;Lichi Shi;Arandi G. Bezerra;Arandi G. Bezerra

  • Proton-Detected Solid-State NMR Reveals Intramembrane Polar Networks in a Seven-Helical Transmembrane Protein Proteorhodopsin

    Meaghan E Ward;Lichi Shi;Evelyn Lake;Sridevi Krishnamurthy

Frequent Co-Authors

Janos K. Lanyi
Janos K. Lanyi University of California, Irvine
Richard Needleman
Richard Needleman Wayne State University
Hideki Kandori
Hideki Kandori Nagoya Institute of Technology
R. J. Dwayne Miller
R. J. Dwayne Miller University of Toronto
Lars Konermann
Lars Konermann University of Western Ontario
Gane Ka-Shu Wong
Gane Ka-Shu Wong University of Alberta
Michael Melkonian
Michael Melkonian Max Planck Society
Mordechai Sheves
Mordechai Sheves Weizmann Institute of Science
Dominique P. Bureau
Dominique P. Bureau University of Guelph
John L. Spudich
John L. Spudich The University of Texas Health Science Center at Houston

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