World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
76
Citations
16789
World Ranking
5143
National Ranking
2449

Overview

Charles E. McCall is affiliated with Wake Forest University in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, Immunology and Microbiology, and Medicine.

The scientist's work focuses on several key topics, including:

  • Immune cells in cancer
  • Inflammasome and immune disorders
  • Tryptophan and brain disorders
  • Immune Response and Inflammation
  • Sepsis Diagnosis and Treatment
  • Biochemical Acid Research Studies
  • Diabetes and associated disorders

Notable recent papers authored or coauthored by McCall include:

  • "Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes," 2020, Journal of Leukocyte Biology
  • "Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation," 2023, Cell Reports
  • "Sirtuins: potential therapeutic targets for regulating acute inflammatory response?," 2020, Expert Opinion on Therapeutic Targets
  • "Inhibiting KDM6A Demethylase Represses Long Non-Coding RNA Hotairm1 Transcription in MDSC During Sepsis," 2022, Frontiers in Immunology
  • "Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction," 2020, bioRxiv (Cold Spring Harbor Laboratory)

Their frequent coauthors include:

  • Manal Zabalawi
  • Xuewei Zhu
  • Cristina M. Furdui
  • Allison K. Meyers
  • Qingxia Zhao

Charles E. McCall's publications have appeared often in several venues, including:

  • Frontiers in Immunology (3 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (3 publications)
  • Cell Reports (1 publication)
  • Journal of Leukocyte Biology (1 publication)
  • Expert Opinion on Therapeutic Targets (1 publication)

The scientist's work addresses complex biological and immunological mechanisms, particularly related to inflammation, immune responses, and metabolic regulation during acute inflammatory events and sepsis. Their research integrates molecular biology and physiological insights to study immune cells and related disorders.

Best Publications

  • NAD+-dependent Sirtuin 1 and 6 Proteins Coordinate a Switch from Glucose to Fatty Acid Oxidation during the Acute Inflammatory Response

    Tie Fu Liu;Vidula T. Vachharajani;Barbara K. Yoza;Charles E. McCall

  • 1-O-Alkyl-sn-glyceryl-3-phosphorylcholines: a novel class of neutrophil stimulants.

    J. T. O'Flaherty;R. L. Wykle;C. H. Miller;J. C. Lewis

  • Characterization of Interleukin-1 Receptor-associated Kinase in Normal and Endotoxin-tolerant Cells

    Liwu Li;Sue Cousart;Jean Hu;Charles E. McCall

  • Subpopulations of neutrophils with increased oxidative product formation in blood of patients with infection.

    D A Bass;P Olbrantz;P Szejda;M C Seeds

  • Sirtuins Link Inflammation and Metabolism.

    Vidula T. Vachharajani;Tiefu Liu;Xianfeng Wang;Jason J. Hoth

  • Choline-linked Phosphoglycerides A SOURCE OF PHOSPHATIDIC ACID AND DIGLYCERIDES IN STIMULATED NEUTROPHILS*

    D E Agwu;L C McPhail;M C Chabot;L W Daniel

  • Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidative metabolism by various agonists. Differential effects of a novel protein kinase inhibitor.

    C Gerard;L C McPhail;A Marfat;N P Stimler-Gerard

  • Complete Deficiency of Leukocyte Glucose-6-Phosphate Dehydrogenase with Defective Bactericidal Activity

    M. Robert Cooper;Lawrence R. DeChatelet;Charles E. McCall;Mariano F. La Via

  • NAD+-dependent SIRT1 Deacetylase Participates in Epigenetic Reprogramming during Endotoxin Tolerance

    Tie Fu Liu;Barbara K. Yoza;Mohamed El Gazzar;Vidula T. Vachharajani

  • Tolerance to endotoxin-induced expression of the interleukin-1 beta gene in blood neutrophils of humans with the sepsis syndrome.

    Charles E. McCall;Lynell M. Grosso-Wilmoth;Karen LaRue;Rosa N. Guzman

  • Lipopolysaccharide priming of alveolar macrophages for enhanced synthesis of prostanoids involves induction of a novel prostaglandin H synthase.

    M G O'Sullivan;F H Chilton;E M Huggins;C E McCall

  • The NF-κB Factor RelB and Histone H3 Lysine Methyltransferase G9a Directly Interact to Generate Epigenetic Silencing in Endotoxin Tolerance

    Xiaoping Chen;Mohamed El Gazzar;Barbara K. Yoza;Charles E. McCall

  • G9a and HP1 Couple Histone and DNA Methylation to TNFα Transcription Silencing during Endotoxin Tolerance

    Mohamed El Gazzar;Barbara K. Yoza;Xiaoping Chen;Jean Hu

  • Phosphatidic acid as a second messenger in human polymorphonuclear leukocytes. Effects on activation of NADPH oxidase.

    D E Agwu;L C McPhail;S Sozzani;D A Bass

  • Endotoxin Tolerance Disrupts Chromatin Remodeling and NF-κB Transactivation at the IL-1β Promoter

    Christopher Chan;Liwu Li;Charles E. McCall;Barbara K. Yoza

  • Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin.

    Rabab El Mezayen;Mohamed El Gazzar;Michael C. Seeds;Charles E. McCall

  • Myeloid-derived suppressor cells evolve during sepsis and can enhance or attenuate the systemic inflammatory response

    Laura Brudecki;Donald A. Ferguson;Charles E. McCall;Mohamed El Gazzar

  • MicroRNAs distinguish translational from transcriptional silencing during endotoxin tolerance.

    Mohamed A. El Gazzar;Charles E. McCall

  • Eosinopenia of Acute Infection: PRODUCTION OF EOSINOPENIA BY CHEMOTACTIC FACTORS OF ACUTE INFLAMMATION

    D A Bass;T A Gonwa;P Szejda;M S Cousart

  • Age-related variations in the methylome associated with gene expression in human monocytes and T cells

    Lindsay M. Reynolds;Jackson R. Taylor;Jingzhong Ding;Kurt Lohman

Frequent Co-Authors

David A. Bass
David A. Bass Wake Forest University
Joseph T. O'Flaherty
Joseph T. O'Flaherty Wake Forest University
Linda C. McPhail
Linda C. McPhail Wake Forest University
Robert L. Wykle
Robert L. Wykle Wake Forest University
Michael J. Thomas
Michael J. Thomas Medical College of Wisconsin
Yongmei Liu
Yongmei Liu Duke University
Liwu Li
Liwu Li Virginia Tech
Xianfeng Wang
Xianfeng Wang Donghua University
David M. Herrington
David M. Herrington Wake Forest University
John S. Parks
John S. Parks Wake Forest University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Charles E. McCall

Trending Scientists

Recently Published Articles