What is he best known for?
The fields of study he is best known for:
- Enzyme
- Biochemistry
- Internal medicine
Robert L. Wykle spends much of his time researching Biochemistry, Platelet-activating factor, Choline, Arachidonic acid and Phosphatidylinositol.
The study incorporates disciplines such as Stimulation and Acyl group in addition to Biochemistry.
His Stimulation research incorporates elements of Phosphatidic acid and Biosynthesis.
The concepts of his Platelet-activating factor study are interwoven with issues in Ionophore, Degranulation, Cytochalasin B and Platelet.
His Choline research focuses on Phosphatidylcholine and how it relates to Canine kidney, Palmitic acid and Diglyceride.
His study in Phosphatidylinositol is interdisciplinary in nature, drawing from both Ether and Sphingomyelin.
His most cited work include:
- 1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine. A common source of platelet-activating factor and arachidonate in human polymorphonuclear leukocytes. (271 citations)
- A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine. (232 citations)
- 1-O-Alkyl-sn-glyceryl-3-phosphorylcholines: a novel class of neutrophil stimulants. (222 citations)
What are the main themes of his work throughout his whole career to date?
Robert L. Wykle mainly investigates Biochemistry, Platelet-activating factor, Arachidonic acid, Phospholipid and Stereochemistry.
His research on Biochemistry often connects related areas such as Stimulation.
His Platelet-activating factor study combines topics from a wide range of disciplines, such as Platelet, Receptor, Ionophore, Phosphocholine and Pharmacology.
As a part of the same scientific family, Robert L. Wykle mostly works in the field of Arachidonic acid, focusing on Phospholipase A2 and, on occasion, Cell biology, Leukotriene B4, Phosphorylation and Cytosol.
His Phospholipid research integrates issues from Fatty acid, Nuclear magnetic resonance spectroscopy and Membrane lipids.
His Stereochemistry research is multidisciplinary, relying on both Structure–activity relationship and Alkyl.
He most often published in these fields:
- Biochemistry (69.89%)
- Platelet-activating factor (48.39%)
- Arachidonic acid (25.81%)
What were the highlights of his more recent work (between 1994-2007)?
- Biochemistry (69.89%)
- Platelet-activating factor (48.39%)
- Arachidonic acid (25.81%)
In recent papers he was focusing on the following fields of study:
Robert L. Wykle mostly deals with Biochemistry, Platelet-activating factor, Arachidonic acid, Phospholipase A2 and Cell biology.
His research on Biochemistry frequently connects to adjacent areas such as Ether.
His Platelet-activating factor study combines topics in areas such as High-performance liquid chromatography, Chromatography, Mass spectrometry, Lipid metabolism and Pharmacology.
His studies in Arachidonic acid integrate themes in fields like Diglyceride, Chemotaxis, Cytosol and Protein kinase C, Phosphorylation.
His work carried out in the field of Chemotaxis brings together such families of science as In vitro, G protein, Pertussis toxin, Degranulation and Eicosanoid.
His Cell biology research focuses on subjects like Leukotriene B4, which are linked to Zileuton, Exocytosis, Lipoxygenase, Arachidonate 5-lipoxygenase and Stimulation.
Between 1994 and 2007, his most popular works were:
- 5-Lipoxygenase Products Modulate the Activity of the 85-kDa Phospholipase A2 in Human Neutrophils (∗) (75 citations)
- 5-Oxo-eicosanoids and Hematopoietic Cytokines Cooperate in Stimulating Neutrophil Function and the Mitogen-activated Protein Kinase Pathway (73 citations)
- 5-Oxo-eicosatetraenoate is a broadly active, eosinophil-selective stimulus for human granulocytes. (62 citations)
In his most recent research, the most cited papers focused on:
- Enzyme
- Biochemistry
- Internal medicine
His scientific interests lie mostly in Biochemistry, Leukotriene B4, Chemotaxis, Tyrosine phosphorylation and Kinase.
His work in Cyclin-dependent kinase 2, Cyclin-dependent kinase 9, ASK1, Phosphatidylethanolamine and Cholesterol is related to Biochemistry.
His research in Leukotriene B4 intersects with topics in Phospholipase A2, Arachidonic acid and Cell biology.
His Arachidonic acid research is multidisciplinary, incorporating elements of Exocytosis, Lipoxygenase and Stimulation.
The various areas that Robert L. Wykle examines in his Chemotaxis study include Protein kinase A, Pertussis toxin, Degranulation, MAPK/ERK pathway and Eicosanoid.
His biological study spans a wide range of topics, including Acetyltransferase and Molecular biology.
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