What is he best known for?
The fields of study he is best known for:
Platelet-activating factor, Cell biology, Biochemistry, PAF acetylhydrolase and Endothelial stem cell are his primary areas of study.
The concepts of his Platelet-activating factor study are interwoven with issues in Inflammation, Cell adhesion, Biological activity, Thrombin and Pharmacology.
His Cell biology study incorporates themes from Platelet activation and Integrin.
As part of one scientific family, he deals mainly with the area of Biochemistry, narrowing it down to issues related to the Mediator, and often Fatty acid and Phospholipase.
His PAF acetylhydrolase research includes elements of Receptor, Phospholipase A2, 1-Alkyl-2-acetylglycerophosphocholine Esterase and Platelet.
The study incorporates disciplines such as Cycloheximide, Complementary DNA, Granulocyte, Endothelium and Cell–cell interaction in addition to Endothelial stem cell.
His most cited work include:
- Rapid neutrophil adhesion to activated endothelium mediated by GMP-140 (931 citations)
- Platelet-activating factor. (840 citations)
- Endothelial cell interactions with granulocytes: tethering and signaling molecules (707 citations)
What are the main themes of his work throughout his whole career to date?
Thomas M. McIntyre mostly deals with Biochemistry, Cell biology, Platelet-activating factor, PAF acetylhydrolase and Endothelial stem cell.
His Cell biology research incorporates elements of Platelet activation, Integrin and Cell adhesion.
His Platelet activation research is multidisciplinary, relying on both Molecular biology and Protease-activated receptor.
His Platelet-activating factor research integrates issues from Inflammation, Receptor, Phospholipase A2 and Platelet.
In his research on the topic of PAF acetylhydrolase, Low-density lipoprotein is strongly related with 1-Alkyl-2-acetylglycerophosphocholine Esterase.
The Endothelial stem cell study combines topics in areas such as Endothelium, Umbilical vein, Thrombin and Granulocyte.
He most often published in these fields:
- Biochemistry (46.37%)
- Cell biology (37.99%)
- Platelet-activating factor (36.31%)
What were the highlights of his more recent work (between 2001-2017)?
- Biochemistry (46.37%)
- Cell biology (37.99%)
- Inflammation (17.32%)
In recent papers he was focusing on the following fields of study:
Thomas M. McIntyre mainly investigates Biochemistry, Cell biology, Inflammation, Immunology and Platelet-activating factor.
His Biochemistry research includes themes of Platelet activation and Pharmacology.
Thomas M. McIntyre is interested in Signal transduction, which is a field of Cell biology.
His research integrates issues of Cell signaling, β2 integrin, Enzyme, Innate immune system and Effector in his study of Inflammation.
His Immunology research incorporates themes from Gene expression, Leukocyte adhesion deficiency and Lung.
Many of his research projects under Platelet-activating factor are closely connected to Platelet-activating factor receptor with Platelet-activating factor receptor, tying the diverse disciplines of science together.
Between 2001 and 2017, his most popular works were:
- Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist (500 citations)
- Escaping the Nuclear Confines: Signal-Dependent Pre-mRNA Splicing in Anucleate Platelets (472 citations)
- The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis. (286 citations)
In his most recent research, the most cited papers focused on:
Thomas M. McIntyre focuses on Cell biology, Inflammation, Immunology, Signal transduction and Biochemistry.
The various areas that he examines in his Cell biology study include Platelet activation, Platelet and Molecular biology.
His studies deal with areas such as Lipopolysaccharide and Ovalbumin, Antigen as well as Inflammation.
His work carried out in the field of Immunology brings together such families of science as Tethering and Desensitization.
His PAF acetylhydrolase, Phospholipase A, Phospholipase C and 1-Alkyl-2-acetylglycerophosphocholine Esterase study, which is part of a larger body of work in Biochemistry, is frequently linked to PON1, bridging the gap between disciplines.
His work focuses on many connections between Cell signaling and other disciplines, such as Mediator, that overlap with his field of interest in Platelet-activating factor.
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