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Biology and Biochemistry

D-Index
85
Citations
37876
World Ranking
3077
National Ranking
231

Overview

Mikael Simons is affiliated with the German Center for Neurodegenerative Diseases in Germany. Their research spans several interconnected fields including Neuroscience, Medicine, and Biochemistry, Genetics and Molecular Biology. Within these domains, their work focuses primarily on subfields such as Neurology, Immunology, Molecular Biology, Physiology, and Developmental Neuroscience.

The primary topics of Simons's research involve Neuroinflammation and Neurodegeneration Mechanisms, Alzheimer's disease research and treatments, Immune cells in cancer, Neurogenesis and neuroplasticity mechanisms, Dementia and Cognitive Impairment Research, Extracellular vesicles in disease, and Phagocytosis and Immune Regulation.

Simons has co-authored extensively with several frequent collaborators, including Martina Schifferer, Özgün Gökçe, Christian Haass, Ludovico Cantuti-Castelvetri, and Johannes Levin. Their published work appears notably in journals such as bioRxiv (Cold Spring Harbor Laboratory), Neuron, Nature Communications, Nature Neuroscience, and Immunity.

Their recent scientific papers include:

  • Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity, 2020, Science
  • Microglia states and nomenclature: A field at its crossroads, 2022, Neuron
  • White matter aging drives microglial diversity, 2021, Neuron
  • Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease, 2023, Nature
  • Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region, 2020, EMBO Molecular Medicine

Best Publications

  • Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

    Katarina Trajkovic;Chieh Hsu;Salvatore Chiantia;Lawrence Rajendran

  • Exosomes--vesicular carriers for intercellular communication.

    Mikael Simons;Graça Raposo

  • Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity.

    Ludovico Cantuti-Castelvetri;Ludovico Cantuti-Castelvetri;Ravi Ojha;Liliana D. Pedro;Liliana D. Pedro;Minou Djannatian;Minou Djannatian

  • Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons.

    Mikael Simons;Patrick Keller;Bart De Strooper;Konrad Beyreuther

  • Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo

    K. Fassbender;M. Simons;C. Bergmann;M. Stroick

  • Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

    Carsten Frühbeis;Dominik Fröhlich;Wen Ping Kuo;Jesa Amphornrat

  • Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

    Dirk Fitzner;Dirk Fitzner;Mareike Schnaars;Denise van Rossum;Gurumoorthy Krishnamoorthy

  • Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C

    Chieh Hsu;Yuichi Morohashi;Shin-ichiro Yoshimura;Natalia Manrique-Hoyos

  • Oligodendrocytes: Myelination and Axonal Support

    Mikael Simons;Klaus Armin Nave

  • Cell type- and brain region-resolved mouse brain proteome

    Kirti Sharma;Sebastian Schmitt;Sebastian Schmitt;Caroline G Bergner;Caroline G Bergner;Stefka Tyanova

  • Myelin in the Central Nervous System: Structure, Function, and Pathology.

    Christine Stadelmann;Sebastian Timmler;Alonso Barrantes-Freer;Mikael Simons

  • Age-related myelin degradation burdens the clearance function of microglia during aging

    Shima Safaiyan;Nirmal Kannaiyan;Nicolas Snaidero;Nicolas Snaidero;Simone Brioschi

  • Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial.

    Mikael Simons;Frank Schwärzler;Dieter Lütjohann;Klaus Von Bergmann

  • Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation

    Mario Hofweber;Saskia Hutten;Benjamin Bourgeois;Emil Spreitzer

  • Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue

    Nicolas Snaidero;Wiebke Möbius;Tim Czopka;Liesbeth H.P. Hekking

  • Defective cholesterol clearance limits remyelination in the aged central nervous system

    Ludovico Cantuti-Castelvetri;Dirk Fitzner;Dirk Fitzner;Mar Bosch-Queralt;Marie-Theres Weil;Marie-Theres Weil

  • Cholesterol and Alzheimer's disease: is there a link?

    Mikael Simons;Patrick Keller;Johannes Dichgans;Jörg B. Schulz

  • Assembly of myelin by association of proteolipid protein with cholesterol- and galactosylceramide-rich membrane domains.

    Mikael Simons;Eva-Maria Krämer;Christoph Thiele;Wilhelm Stoffel

  • Efficient Inhibition of the Alzheimer's Disease β-Secretase by Membrane Targeting

    Lawrence Rajendran;Anja Schneider;Georg Schlechtingen;Sebastian Weidlich

  • Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders

    Anja Schneider;Mikael Simons;Mikael Simons

Frequent Co-Authors

Wiebke Möbius
Wiebke Möbius Max Planck Society
Klaus-Armin Nave
Klaus-Armin Nave Max Planck Society
Doron Merkler
Doron Merkler University of Geneva
Jörg B. Schulz
Jörg B. Schulz RWTH Aachen University
Thomas Misgeld
Thomas Misgeld Technical University of Munich
Martin Kerschensteiner
Martin Kerschensteiner Ludwig-Maximilians-Universität München
Sandra Goebbels
Sandra Goebbels Max Planck Society
Kai Simons
Kai Simons Lipotype
Stefan W. Hell
Stefan W. Hell Max Planck Society
Andreas Janshoff
Andreas Janshoff University of Göttingen

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