Mikael Simons focuses on Cell biology, Microvesicles, Secretion, Axon and Myelin. The various areas that Mikael Simons examines in his Cell biology study include Vesicle and Neuron. With his scientific publications, his incorporates both Microvesicles and Cell signaling.
Mikael Simons studied Axon and Central nervous system that intersect with Live cell imaging and Cytoplasm. In his study, Myelinated nerve fiber, Transduction, Myelin sheath and Membrane structure is strongly linked to Nervous system, which falls under the umbrella field of Myelin. His research in Transport protein intersects with topics in Membrane transport and ESCRT, Endosome.
His primary areas of study are Cell biology, Myelin, Neuroscience, Central nervous system and Axon. Mikael Simons has included themes like Secretion and Exocytosis in his Cell biology study. His study in Myelin is interdisciplinary in nature, drawing from both Biochemistry and Function.
His work carried out in the field of Neuroscience brings together such families of science as Multiple sclerosis, Immunology and Neurodegeneration. His work deals with themes such as Nerve conduction, Progenitor cell, Anatomy and Nervous system, which intersect with Central nervous system. His research integrates issues of Cell and Actin cytoskeleton in his study of Axon.
Myelin, Central nervous system, Cell biology, Neuroscience and Remyelination are his primary areas of study. His Myelin research includes themes of Inflammation resolution and Innate immune system. His Central nervous system research focuses on subjects like Pathology, which are linked to Myelin membrane and Stereotactic injection.
His biological study spans a wide range of topics, including Oligodendrocyte differentiation and Microglia. In the field of Neuroscience, his study on Oligodendrocyte, Cortex and Neuroplasticity overlaps with subjects such as Grey matter. His Remyelination research is multidisciplinary, relying on both Cerebral cortex, Cholesterol, Immune system and Nervous system.
His primary scientific interests are in Central nervous system, Myelin, Nerve conduction, Neuroscience and Remyelination. His Myelin study integrates concerns from other disciplines, such as Cytoplasm, Biochemistry, Cell biology and Actin cytoskeleton. His work on Axon as part of general Cell biology research is frequently linked to 2',3'-Cyclic-nucleotide 3'-phosphodiesterase, thereby connecting diverse disciplines of science.
The concepts of his Nerve conduction study are interwoven with issues in Myelin membrane and Pathology. His Neuroscience research is multidisciplinary, incorporating perspectives in Progenitor cell and Multiple sclerosis. His Remyelination research integrates issues from Immune system, Cholesterol, Regeneration and Nervous system.
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Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
Katarina Trajkovic;Chieh Hsu;Salvatore Chiantia;Lawrence Rajendran.
Science (2008)
Exosomes--vesicular carriers for intercellular communication.
Mikael Simons;Graça Raposo.
Current Opinion in Cell Biology (2009)
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons.
Mikael Simons;Patrick Keller;Bart De Strooper;Konrad Beyreuther.
Proceedings of the National Academy of Sciences of the United States of America (1998)
Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C
Chieh Hsu;Yuichi Morohashi;Shin-ichiro Yoshimura;Natalia Manrique-Hoyos.
Journal of Cell Biology (2010)
Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis
Dirk Fitzner;Dirk Fitzner;Mareike Schnaars;Denise van Rossum;Gurumoorthy Krishnamoorthy.
Journal of Cell Science (2011)
Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication
Carsten Frühbeis;Dominik Fröhlich;Wen Ping Kuo;Jesa Amphornrat.
PLOS Biology (2013)
Cell type- and brain region-resolved mouse brain proteome
Kirti Sharma;Sebastian Schmitt;Sebastian Schmitt;Caroline G Bergner;Caroline G Bergner;Stefka Tyanova.
Nature Neuroscience (2015)
Oligodendrocytes: Myelination and Axonal Support
Mikael Simons;Klaus Armin Nave.
Cold Spring Harbor Perspectives in Biology (2016)
Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue
Nicolas Snaidero;Nicolas Snaidero;Wiebke Möbius;Wiebke Möbius;Tim Czopka;Liesbeth H.P. Hekking.
Cell (2014)
Efficient Inhibition of the Alzheimer's Disease β-Secretase by Membrane Targeting
Lawrence Rajendran;Anja Schneider;Georg Schlechtingen;Sebastian Weidlich.
Science (2008)
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